Active ingredient: fluoxetine
Few data are available from clinical trials and other studies regarding the concomitant use of fluoxetine and alcohol. However, although fluoxetine has not shown to alter the metabolism of alcohol and does not seem to potentiate the cognitive and psychomotor effects of this substance in healthy volunteers, it is not recommended to drink alcohol while under treatment with fluoxetine.
Only has been documented an interaction of alcohol and fluoxetine consistent in a reduction of the anxiolytic effects of ethanol in laboratory animals that could not to be related to their antidepressant properties, since other inhibitors of serotonin reuptake not show this effect at usual doses.
It have been published some isolated cases of alcohol intolerance in patients receiving fluoxetine.
It appears that administration of fluoxetine and ethanol neither produces increased levels of ethanol in the blood nor produces significant changes in physiological , psychometric or psychomotor performance or activities .
Some experiments have shown that inhibitors of serotonin reuptake produces a decrease in ethanol consumption in laboratory animals and also shows comparable effects in humans, with an average reduction of consumption by 20-30%. The effects on ethanol intake are different of antidepressant properties of these drugs, that may be due to the facilitation of satiety signals.
Twelve healthy volunteers received amitriptyline, fluoxetine and placebo at clinically relevant doses during a period of 7 days, with an interval between each change of medicines of 4 weeks. Day 8 were given a measured dose of alcohol. Significant differences were found for many of the tests after alcohol, but not was found significant differences between drugs .
Fluoxetine (30 or 60 mg) administered with ethanol (45 ml of absolute alcohol per 70 kg body weight) did not alter the blood or plasmatic concentrations of fluoxetine or ethanol, respectively, compared with the levels reached after the administration of either substance alone. Single or multiple doses of fluoxetine had no effect on psychomotor activity, motor performance, or manual coordination or subjective effects of alcohol. Data indicate that fluoxetine does not inhibit the metabolism of ethanol and has no effect on psychomotor activity
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