May 23 2022

Active ingredient: alprazolam

As with other drugs acting on the CNS, patients taking alprazolam should avoid activities requiring mental alertness, clear judgment and adequate physical coordination such as driving or operating machinery. This is especially important during the early periods of dosage adjustment and until it has been determined that the patient has no drowsiness or dizziness during treatment.

When combined, alcohol and a benzodiazepine produced unpredictable CNS depressant effects, so it should never be mixed when going to drive a vehicle.

A study of 18 healthy volunteers aged 20 to 45 years showed a significant alteration of the ability to drive at 4 or 5 hours of taking the drug, both immediate release formulations and delayed.

The impaired ability to drive was lower in the extended-release, but of sufficient magnitude to seriously increase the risk of being involved in traffic accidents [1].

The classic study Verster et al., a double-blind comparative trial versus placebo, concluded that alprazolam significantly impaired psychomotor and memory performance, and also the ability to drive in laboratory tests in a study on 20 healthy volunteers. The authors believe that drivers should be advised to avoid driving or operating potentially dangerous machinery when receiving treatment with alprazolam [2].


1: Leufkens TR, Vermeeren A, Smink BE, van Ruitenbeek P, Ramaekers JG. Cognitive, psychomotor and actual driving performance in healthy volunteers after immediate and extended release formulations of alprazolam 1 mg. Psychopharmacology (Berl). 2007 May;191(4):951-9.
2: Verster JC, Volkerts ER, Verbaten MN. Effects of alprazolam on driving ability, memory functioning and psychomotor performance: a randomized, placebo-controlled study. Neuropsychopharmacology. 2002 Aug;27(2):260-9.