May 23 2022

Active ingredient: acenocoumarol

The daily dose should always be ingested into a single take at the same time every day, separate as much as possible of the meals.

The factors that increase or decrease the absorption, accumulation and utilization of vitamin K can interfere with the anticoagulant effect. In this regard, it is important not only a balanced diet but also stable over time, without abrupt changes from one day to another in order to set a dose which does not require substantial variations.

Foods rich in vitamin K, such as broccoli, lettuce, turnip, cabbage, Brussels sprouts, spinach, and other cruciferous vegetables may counteract the effect of warfarin.

Other foods or supplements like garlic may potentiate the adverse effects of oral anticoagulant or decrease its effect. To avoid undesirable reactions, the golden rule is to maintain a stable diet, ie always consume the same or similar foods. Note that the known data come almost always from communications of isolated cases and not from systematic studies, so it is unlikely to suffer unwanted influences by maintaining a regular diet without excess.

Green tea (Camellia sinensis) contains high amounts of vitamin K, so you should limit your intake.

Avoid drinking cranberry juice and/or grapefruit juice during treatment with acenocoumarol, as it may increase the anticoagulant effect and bleeding risk.

Chronic alcohol consumption increases the metabolism of the anticoagulant, which may decrease the effect of this medicine. In contrast, occasional consumption of large amounts of alcohol can reduce anticoagulant metabolism and increase its effect.