Active ingredient: aliskiren
This medication should be taken with little food and with little or no fat in a single daily dose, preferably at the same time every day. Patients should establish a routine for taking aliskiren with regard to meals.
The fat meals decrease absorption of the drug significantly. When taken with a high fat meal, the AUC and Cmax of aliskiren are reduced by 71% and 85% respectively. However, in clinical trials of aliskiren, it was administered without any fixed relationship to meals.
Do not drink grapefruit juice with aliskiren, as it decreases the AUC and Cmax of this antihypertensive. For a dose of 150 mg of this substance, there was a decrease in AUC of 61%, whereas that of 300 mg, the reduction was 38%.