May 23 2022




Active ingredient: alprazolam

Concurrent administration of alprazolam with food does not influence the extent of absorption of simple or orodispersible tablets, although the absorption rate is lower than in the fasted state. However, the difference is minimal and not clinically important[1][2]. Extended release tablets are minimally affected by food, being the difference of absorption as low as 3%, so this form may be taken independently of meals[3].

References:

1: Erdman K, Stypinski D, Combs M, Witt P, Stiles M, Pollock S. Absence of food effect on the extent of alprazolam absorption from an orally disintegrating tablet. Pharmacotherapy. 2007 Aug;27(8):1120-4.
2: Scavone JM, Greenblatt DJ, Goddard JE, Friedman H, Harmatz JS, Shader RI. The pharmacokinetics and pharmacodynamics of sublingual and oral alprazolam in the post-prandial state. Eur J Clin Pharmacol. 1992;42(4):439-43.
3: Eller MG, Della-Coletta AA. Absence of effect of food on alprazolam absorption from sustained release tablets. Biopharm Drug Dispos. 1990 Jan-Feb;11(1):31-7.