May 23 2022




Active ingredient: atorvastatin

Although meal decreases the rate and extent of drug absorption by approximately 25% and 9% respectively, as it is shown by Cmax and AUC, reduced LDL-C and raising HDL-C are similar when atorvastatin is taken with and without food.

Atorvastatin plasma concentrations are lower (approximately 30% for Cmax and AUC) following evening administration compared with morning taking. However, the reduction in LDL-C and raising HDL-C are the same regardless of the hour of administration.

Has been shown that grapefruit juice in large amounts interferes with the metabolism of atorvastatin, leading to increases in Cmax and AUC. Coadministration of CYP3A4 inhibitors (grapefruit juice, for example) can increase the plasma concentrations of the HMG CoA reductase inhibitors, including atorvastatin. Thus, taking 1200 ml of this juice increases the AUC of atorvastatin 2.5 times.

By these reasons, it is not recommended to drink excessive amounts of grapefruit juice with atorvastatin or similar drugs.

It has been shown a decrease in plasma concentrations of atorvastatin by 35% after administration of antacids containing aluminum or magnesium. However the antacids not altered LDL cholesterol reduction, but may impair the reduction of triglycerides.