Active ingredient: ciprofloxacin
Ciprofloxacin hydrochloride can be taken before or after meals, although absorption may be faster on an empty stomach. Patients should be advised to drink fluids liberally and avoid taking dairy products or antacids containing magnesium or aluminum. The drug should be administered at least 2 hours before or 6 hours after antacids or mineral supplements that contain magnesium or aluminum   .
The administration of oral ciprofloxacin with dairy products or calcium-fortified juices alone (ie without food) or a significant intake of calcium (over 800 mg) can reduce the absorption gastrointestinal of ciprofloxacin  .
In one study, a dose of 500 mg of ciprofloxacin with 300 ml of whole milk (360 mg of calcium, 33 mg magnesium) or plain yogurt (450 mg of calcium, 40 mg magnesium) decreased AUC by 33 and 36%, respectively, and lower peak plasma concentrations at 36 and 47%, respectively, compared with the administration of water.
The manufacturer claims that the absorption is not affected by an essential dietary calcium, ie forming part of the meals.
Caffeine has been shown to interfere with the metabolism and pharmacokinetics of ciprofloxacin. Avoid excessive consumption of this substance  [7   .
Ferrous sulfate and multivitamins with zinc significantly impair the absorption of ciprofloxacin and is likely to be clinically significant .
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