May 23 2022




Active ingredient: diazepam

Following oral administration of an usual dose, diazepam is absorbed almost completely (>90%). Absorption is delayed and decreased if the drug is taken together with a moderately fatty meal.

If there is food in the stomach, the interval until the onset of the effects of diazepam is delayed from 15 to 45 minutes, increasing also the time needed to reach the peak concentration (Tmax), going from an average of 75 minutes fasting to 150 when the stomach contains food. Overall, there is a decrease in Cmax of 20% and the area under curve (AUC) of 27%.

However, a light meal slows but does not affect the Tmax peak concentration or the AUC [1].

Beverages containing caffeine or grapefruit juice and antacids may modify the effect of diazepam or its extent of absorption.

Reference:

1: Yamazaki A, Kumagai Y, Fujita T, Hasunuma T, Yokota S, Maeda M, Otani Y, Majima M. Different effects of light food on pharmacokinetics and pharmacodynamics of three benzodiazepines, quazepam, nitrazepam and diazepam. J Clin Pharm Ther. 2007 Feb;32(1):31-9.