May 23 2022

Active ingredient: diclofenac

Onset of absorption is delayed when diclofenac sodium is administered orally as delayed release tablets (enteric coated), but the extent of absorption do not appears to be modified.

Have been observed measurable plasma concentrations of diclofenac in some individuals fasting after 10 minutes of taking conventional diclofenac potassium tablets.

Food decreases absorption rate of both types of tablets (conventional and delayed release tablets), which results in peak plasma levels lower and delayed compared to taking the drug on an empty stomach. However, the degree of absorption is not substantially affected.

When diclofenac potassium is administered as conventional tablets with food, the time to reach peak plasma concentration increases and the maximum plasma drug concentration is reduced by approximately 30%.

When extended release tablets of diclofenac are taken with food, the onset of absorption is delayed 1-2 hours and maximum plasma concentrations are increased twice. However, the degree of absorption is not affected substantially.

Absorption of diclofenac not appear to be affected by the presence of food in a continuous delivery system. Antacids can also reduce the rate but not the extent of absorption.

In brief, if the purpose of administering this drug is rapid relief of symptoms, it is preferable to take it on an empty stomach; the manufacturer recommends do it before eat. If however, the drug is taken continuously, hardly it seems relevant if taken before, during or after meals.