Active ingredient: lincomycin
Bioavailability of lincomycin is dependent on gastric content. Thus, bioavailability of this drug is 71% in fasting state, while if taken with food is 41%. Moreover, Cmax is nearly twice in fasting that after eating, 8 and 5 mcg / ml, according to data from animal experiments.
Therefore, to achieve adequate absorption of lincomycin, should be avoided ingestion of food or beverages from two hours before to two hours after taking the drug .
Cyclamate as additive of certain foods and beverages reduces the absorption of lincomycin.
1: Nielsen P, Gyrd-Hansen N. Bioavailability of spiramycin and lincomycin after oral administration to fed and fasted pigs. J Vet Pharmacol Ther. 1998 Aug;21(4):251-6.