May 23 2022




Active ingredient: losartan

Foods delay absorption of losartan and decreases its Cmax but has minor effects on the extent of absorption of losartan and its major metabolite, whose decrease is lower than 10%.

In summary, losartan can be administered with or without food, but it is advisable to always take it the same way with regards to meals and at the same time each day.

It should avoid excessive intake of potassium, including substitutes common salt and potassium supplements because, otherwise, there is an increased risk of excessive elevation of this element in the blood, which could become important.

As is known, ARA II medicines, group to which belongs losartan, favor the elevation of potassium in the blood by inhibiting the secretion of aldosterone.

In patients with certain chronic diseases, such as heart failure or kidney failure and diabetes mellitus, hyperkalemia risk is particularly high.

Grapefruit juice may modestly decrease and delay the conversion of losartan to its active metabolite, probably through inhibition of CYP3A4. The clinical relevance of this interaction is unknown. It seems prudent to limit or avoid drinking this juice and control the clinical efficacy of this antihypertensive[1][2].

References:

1: Bailey DG, Dresser GK.Interactions between grapefruit juice and cardiovascular drugs.Am J Cardiovasc Drugs. 2004;4(5):281-97.
2: Zaidenstein R, Soback S, Gips M, Avni B, Dishi V, Weissgarten Y, Golik A, Scapa E. Effect of grapefruit juice on the pharmacokinetics of losartan and its active metabolite E3174 in healthy volunteers. Ther Drug Monit. 2001 Aug;23(4):369-73.