May 23 2022

Active ingredient: sertraline

The bioavailability and absorption rate of sertraline increase slightly but consistently if the drug is taken with food. Nevertheless, this drug can be administered with or without food, according to the findings of a study on sertraline pharmacokinetics carried out by researchers from the company manufacturer[1].

Grapefruit juice increases the peak plasma concentration and AUC of sertraline, as is clear from the results of studies in healthy volunteers. This fact should be considered in patients receiving antidepressant[2][3].


1: 1. Ronfeld RA, Wilner KD, Baris BA.Sertraline. Chronopharmacokinetics and the effect of coadministration with food. Clin Pharmacokinet. 1997;32 Suppl 1:50-5.
2: Ueda N, Yoshimura R, Umene-Nakano W, Ikenouchi-Sugita A, Hori H, Hayashi K, Kodama Y, Nakamura J. Grapefruit juice alters plasma sertraline levels after single ingestion of sertraline in healthy volunteers. World J Biol Psychiatry. 2009;10(4 Pt 3):832-5. doi: 10.1080/15622970802688069.
3: Lee AJ, Chan WK, Harralson AF, Buffum J, Bui BC. The effects of grapefruit juice on sertraline metabolism: an in vitro and in vivo study. Clin Ther. 1999 Nov;21(11):1890-9.