May 23 2022

Active ingredient: sildenafil

Sildenafil is rapidly absorbed after oral administration with a bioavailability of 41% [1]. Ingestion of a high-fat meal before taking this drug causes a slower absorption, taking an additional hour to reach peak concentration (Tmax), but does not alter substantially extent of absorption. While during fasting the drug starts its effect within 30 minutes, after a fatty meal takes 90 minutes on average. From the point of view of efficiency, this delay is of minor importance, so that taking before or after a meal does not affect the overall effectiveness of the drug [2].

However, one way to overcome this little problem is to use sublingual administration of sildenafil, faster and probably not influenced by gastric content[3][4].


1: Nichols DJ, Muirhead GJ, Harness JA. Pharmacokinetics of sildenafil after single oral doses in healthy male subjects: absolute bioavailability, food effects and dose proportionality. Br J Clin Pharmacol. 2002;53 Suppl 1:5S-12S.
2: Zinner N. Do food and dose timing affect the efficacy of sildenafil? A randomized placebo-controlled study. J Sex Med. 2007 Jan;4(1):137-44.
3: De Siati M, Saugo M, Franzolin N. The start of pharmacological activity after sublingual administration of sildenafil citrate in 30 patients affected by erectile dysfunction. Arch Ital Urol Androl. 2003 Mar;75(1):18-20.
4: Deveci S, Pe?kircio?lu L, Ayg?n C, Tekin MI, Dirim A, Ozkarde? H. Sublingual sildenafil in the treatment of erectile dysfunction: faster onset of action with less dose. Int J Urol. 2004 Nov;11(11):989-92.