May 27 2022


Alfentanil, a substance similar to fentanyl, but only for parenteral presentation is transferred to the baby after birth to an insignificant extent, since it binds in a high proportion to plasma proteins and a lesser proportion passes into breast milk than others opiates.

It is unlikely that timely administration during labor may influence the newborn, although in the case of being required repeated administration of alfentanil, once breastfeeding is established, it would be replacing or supplementing with other better known analgesic agent, since there is no clinical documentation enough to establish its safety for the infant.

Some studies indicate that the amount of substance transferred through milk to the baby could be 0.2 mcg / kg, which is far from the therapeutic dose that can be given directly to the infant (30 mcg / kg / hour).

In one study on nine women undergoing postpartum tubal ligation, significant levels of alfentanil were detected in colostrum four hours after administration of 60 ?g/kg of alfentanil, with no detectable levels after 28 hours. Caution should be exercised when alfentanil is administered to a nursing woman.

Warning of the manufacturer:

Alfentanil may be excreted in breast milk and therefore breastfeeding is not recommended until after 24 hours from the last administration.