May 27 2022


Amitriptyline may not cause adverse effects on the baby, as both this substance and its active metabolites, mainly nortriptyline, reach a low concentration in milk. However, the presence of these active metabolites makes preferable the use of other antidepressants in the case of small or premature infants.

Have been reported no adverse effects immediate or long-term of amitriptyline on the infant. In studies limited to a few cases, the drug concentration in the baby's blood was considered undetectable. It is estimated that, at most, the child may receive less than 2% of the maternal dose.

Warning of the manufacturer:

Tricyclic antidepressants are excreted in human milk. Because of the possible adverse reactions that can lead to the infant, should be assessed if discontinue nursing or discontinue treatment with the antidepressant.