May 27 2022




Recommendations

Risks to the infant

A small study suggests that there may be an increased frequency of bowel liquid content (3 of 25 cases, collecting data from a telephone questionnaire).

These data do not coincide with those of another prospective study, in which were not significant differences among infants whose mothers took amoxicillin while nursing compared to children of mothers who did not take antibiotics.A recent study, comparative with other medicines, recorded two cases of diarrhea and a rash among 40 infants whose mothers took amoxicillin. The possible influence of this antibiotic on the infant has not been evaluated in depth.

Influence on lactation

Amoxicillin in milk reaches its maximum concentration at 4-5 hours after the intake. With a standard dose to the mother (1,500 mg), an exclusively breastfed infant would receive, according to estimates based on the concentration in breast milk, a dose of 0.25 to 0.5% of that used for the treatment of an infection of the infant itself.

Recommendations

Amoxicillin is compatible with breastfeeding.

References:

1.Benyamini L, Merlob P, Stahl B et al. The safety of amoxicillin/clavulanic acid and cefuroxime during lactation. Ther Drug Monit. 2005;27:499-502.
2.Campbell AC, McElnay JC, Passmore CM. The excretion of ampicillin in breast milk and its effect on the suckling infant. Br J Clin Pharmacol. 1991;31:230p.
3.Chung AM, Reed MD, Blumer JL. Antibiotics and breast-feeding: a critical review of the literature. Pediatr Drugs 2002;4:81737.
4.Ito S, Blajchman A, Stephenson M et al. Prospective follow-up of adverse reactions in breast-fed infants exposed to maternal medication. Am J Obstet Gynecol. 1993;168:1393-9.
5.Kafetzis DA, Siafas CA, Georgakopoulos PA et al. Passage of cephalosporins and amoxicillin into the breast milk. Acta Paediatr Scand. 1981;70:285-8.
6.Matheson I, Samseth M, Loberg R, Faegri A, Prentice A. Milk transfer of phenoxy-methylpenicillin during puerperal mastitis. Br J Clin Pharmacol 1988;25:3340.
7.Mathew JL. Effect of maternal antibiotics on breast feeding infants.Postgrad Med J. 2004 Apr;80(942):196-200.
8.Vorherr H. Drug excretion in breast milk. Postgrad Med 1974;56:97104.

Warning of the manufacturer:

Amoxicillin may be administered during nursing. No effects are known in the infant, except potential sensitization risk due to the presence of traces of amoxicillin in breast milk.

Updated:13.04.08