May 27 2022


Limited data indicate that, probably, buprenorphine is excreted in small amounts in milk. In general, it is preferable to use another medication better known, especially in the case of premature and very young babies.

The proportion of the substance that is found in milk will usually have a range equal to or less than 1-2.5% of the total dose given to the mother, being especially low when the drug is administered orally.

For children of drug-addicted mothers, the administration of buprenorphine to the nursing mother does not prevent withdrawal symptoms in the baby, which is due to the low level of drug transfer.

No sufficient reason to stop breast-feeding when necessary buprenorphine administered to the mother, although the infant should be monitored for signs indicative of sleepiness, inadequate weight gain or poor psychomotor maturation.

Has been reported that administration of buprenorphine extradural in caesarean anesthesia procedures, produced a lower intake of milk and lower weight gain of infants compared with children of patients to which the drug was not administered.

Warning of the manufacturer:

Buprenorphine inhibits the production of milk and eliminated through the milk. Therefore, buprenorphine should not be used during lactation.