May 27 2022




Recommendations

Carbamazepine is considered compatible with breastfeeding, although this substance reaches in the infant proportionally higher concentrations than other drugs.

It is estimated that the concentration in breastmilk of carbamazepine can be half of that reached in the mother's blood, though this ratio can vary considerably, ranging between 30 and 80%. Other observations estimate the blood concentration in the baby about 44% of that of the mother.

As with other anticonvulsants, it should relativized the validity of these estimates, because usually is taken concurrently with other medications that can significantly modify the pharmacokinetics of this substance

In most of the cases reported, adverse reactions are infrequent and well tolerated. Have been reported some timely adverse reactions as withdrawal syndrome, drowsiness, jaundice, liver enzyme abnormalities, seizures and weak suck, not always directly attributable to carbamazepine, but other drugs taken simultaneously.

If it is necessary to administer this substance can continue to feed the baby with breastfeeding, but should be monitored psychomotor development and weight and possible signs of liver damage and / or sedation.

Warning of the manufacturer:

During lactation, carbamazepine concentration in human milk, varies between 30% and 60% of the plasma concentration of the mother. Although the amount ingested by the infant is small to cause any adverse reaction, should be discontinued breastfeeding unless it is strictly necessary for the child.

Updated:18.03.08