Probably carvedilol is a substance of acceptable use during breastfeeding. However, there is no published clinical experience to support its use, so it is preferable to use an alternative drug.
The favorable pharmacokinetics of this substance do unlikely to pose a risk to the baby as it is excreted in a low amount through milk.
Carvedilol in plasma is bound to proteins in 95%, which significantly reduces the possibility of removal by means of the milk and its half-life is not particularly long, which reduces the risk of accumulation .
Warning of the manufacturer:
As with other beta-blocker agents, studies conducted in rats in period of nursing pups showed that carvedilol and/or its metabolites are excreted in breast milk. Therefore is not recommended to administer carvedilol during breastfeeding.