May 27 2022


Most likely, divalproex is compatible with breastfeeding, since it is the combination of two molecules of valproic acid, which is compatible with lactation. As is known, that substance is directly converted into valproic acid in the body, so they are superimposable drugs.

Although there have been some observations of adverse effects on infants during administration to the mother of valproic acid, probably most of them are not attributable solely to it.

A case of sedation in the child of a woman who received valproic acid along with primidone was resolved at stop breastfeeding. The effect is attributed to primidone, although the former could help raise the levels of the latter.

As is known, valproic acid is potentially hepatotoxic, so that infants whose mothers are treated with this substance should be closely monitored for the possible occurrence of liver damage. It has been published a case of thrombocytopenia and petechiae, so it should be alerted about possible early signs of bleeding tendency.

Warning of the manufacturer:

Valproic acid derivatives are eliminated through breast milk. Concentrations may reach 10% of that of maternal plasma. It is not known what effect this drug may cause in the infant. Consideration should be given to discontinue breastfeeding when administered divalproex to the mother .