May 27 2022


Doxepin is transformed into N-desmethyldoxepin, which has a similar pharmacological activity to that.

Since there have been reports of significant adverse reactions, such as hypotonia, drowsiness, respiratory depression, weight loss, weak suction and other symptoms, it is preferable to use an alternative drug with a better safety profile , especially when it is a small or premature infant.

Warning of the manufacturer:

It was published a case of apnea and drowsiness in an infant whose mother was taking doxepin. Since the drug passes into breast milk, nursing mothers should avoid breast-feeding their children if they take this medicine.