May 27 2022




Recommendations

Risks to the infant

Although drug use is widespread, it has only about twenty cases reported in the medical literature published regarding infants breastfed while his mother received ibuprofen. No adverse effects have been reported[1, 2, 3].

Influence on lactation

There are no known effects on lactation. The presence of ibuprofen in breast milk is undetectable or very low[1,4] . Administration of 1200 mg of substance to a nursing mother provides a daily dose to infants of about 17 mcg/kg body weight, representing a dose lower than 0.001% of the maternal.

Recommendations

Ibuprofen is an anti-inflammatory of choice for nursing mothers, because of its low concentration in the milk and its short half-life.

References

1.Weibert RT, Townsend RJ, Kaiser DG, Naylor AJ. Lack of ibuprofen secretion into human milk. Clin Pharm. 1982 Sep-Oct;1(5):457-8.

2.Walter K, Dilger C. Ibuprofen in human milk. Br J Clin Pharmacol. 1997 Aug;44(2):211-2.

3.Ito S, Blajchman A, Stephenson M. Prospective follow-up of adverse reactions in breast-fed infants exposed to maternal medication. Am J Obstet Gynecol. 1993 May;168(5):1393-9.

4.Townsend RJ, Benedetti TJ, Erickson SH, Cengiz C, Gillespie WR, Gschwend J, Albert KS. Excretion of ibuprofen into breast milk.Am J Obstet Gynecol. 1984 May 15;149(2):184-6.

Warning of the manufacturer:

Although ibuprofen concentrations are achieved in breast milk are negligible and are not expected undesirable effects on the nursing infant is not recommended to use ibuprofen during breastfeeding due to the potential to inhibit other synthesis of prostaglandins in the newborn.

Updated:14.04.08