May 27 2022


Have not been reported cases of adverse effects, both immediately and long term, in infants whose mothers received imipramine during lactation. However, it is preferable to use other antidepressant drugs, especially for premature infants or very small, if the dose administered exceed the normal range.

Imipramine is metabolized to desipramine, and this in turn to 2-OH-desipramine. These three substances have a similar pharmacological effect. Based on the available studies, it is believed that the baby can ingest up just under 3% of the maternal dose of imipramine. In the blood of these children can be found only modest concentrations of imipramine and its metabolite desipramine, which can range from undetectable levels to below 10 mcg/L.

Imipramine may cause rarely galactorrhea through increased prolactin.

Warning of the manufacturer:

Imipramine should not be used during pregnancy or breastfeeding.

If taken this medicine during the last three months of pregnancy, the infant may be born with respiratory distress, lethargy, colic, irritability, abnormal blood pressure, tremors and spasms. Imipramine must be withdrawn at least seven weeks before the expected date of delivery.