May 27 2022


Meperidine is listed as compatible with breastfeeding. However, this substance can cause sedation to a similar extent than morphine, so it is advisable to replace it with non-narcotic analgesic drug, especially in the case of very small or premature infants, due to eventual risk of neurological or cardiorespiratory depression.

In the case of deem necessary its use in a nursing mother, should be monitored for possible occurrence of drowsiness, difficulty in feeding or breathing or any deterioration in general, which would force to conduct an immediate medical intervention.

Meperidine is metabolized worse in young infants, especially in the newborn. These children also have a higher degree of bioavailability than adults and are more sensitive to the central depressant action of the active metabolite normeperidine that adults and older children.

Warning of the manufacturer:

Meperidine is detectable in the milk of lactating women. Because of the potential for severe adverse effects in lactating women, should be chosen to discontinue nursing or administration (or replacement) of meperidine, valuing the expected benefit of the drug in women.