May 27 2022




Recommendations

At usual doses, metoprolol is considered compatible with breastfeeding.

The amounts transferred of metoprolol through breast milk are small and not likely to cause disruption to the infant. However, the risk of accumulation in the infant is greater than in other beta-blockers, because the plasma protein binding is 10% and renal excretion is 40% (see propranolol).

It is estimated that an exclusively breastfed infant would receive a dose of 0.07 mg/kg of metoprolol when the mother receives 200 mg of drug per day.

Warning of the manufacturer:

Metoprolol should not be used during pregnancy and lactation unless its use is deemed essential. Beta-blockers may cause side effects such as bradycardia in the fetus, the newborn and the infant.

However, the amount of metoprolol ingested through breast milk is negligible in relation to a possible beta-blocker effect on the child, if the mother is treated with metoprolol at usual therapeutic doses.

Updated:15.10.08