May 27 2022


Midazolam is excreted in breast milk in small quantities, so it probably will not cause any disruption in the infant when administered to the mother for a short period of time, such as during anesthesia. However, during prolonged use of the drug can accumulate in the mother and affect the baby.

This drug is transformed into two hydroxylated derivatives, equally active. The 1-OH-midazolam has a half-life period of twelve hours so we could accumulate if the mother takes the drug repeatedly.

No data are available from observations in mothers receiving midazolam continuously, nor reported cases of adverse reactions in the infant caused by maternal consumption of midazolam.

It seems prudent to choose an alternative drug for the mother that needs a hypnotic.

Warning of the manufacturer:

Benzodiazepines are excreted in breast milk so you should consult with your doctor the advisability of taking midazolam while breastfeeding the baby.