May 27 2022


A small number of studies with few patients about the possible influence of nortriptyline administered to the mother does not seem to detect adverse effects in infants, both immediately and long term. For some experts, the antidepressant nortriptyline would be of choice during breastfeeding, although can not categorically affirm, due to scarce reported experience.

Some observations, including published and unpublished data, ensure that the infant ingests an amount not exceeding 10% of the weight-adjusted maternal dose, although the substance is rarely detected in the blood of children. Another study, however, estimated that the percentage passing to the baby is 1.3%. Sometimes the hydroxylated active metabolites with pharmacological activity of 50% of the original substance are found at low concentration in the baby's blood.

Warning of the manufacturer:

Tricyclic antidepressants are excreted in small amounts in breast milk. Therefore is not recommended for use by breast-feeding women.