May 22 2022




Recommendations

Available studies indicate that this drug can be found in breast milk in small amounts, it almost never has been detected in infants whose mothers received the drug.

Some published data estimate that, at normal doses, the amount ingested by the infant does not exceed 1.4% of the amount given to the mother.

The Australian ADRAC has reported a case of difficulty feeding and agitation in an infant, probably caused by the maternal administration of paroxetine.

In a cohort of 36 mothers who received paroxetine during the third trimester of pregnancy, eight infants showed symptoms such as drowsiness, constipation and irritability, compared to the absence of these manifestations in the control group, whose mothers had not taken the drug. It has been reported a case of syndrome of inappropriate ADH secretion attributed to taking paroxetine by the mother.

Have been reported several observations of infants exposed to paroxetine in which weight and psychomotor development was normal. To many experts, despite the observations above mentioned, paroxetine is an antidepressant of choice when the patient is breast-feeding a baby.

Warning of the manufacturer:

Through breast milk are excreted small amounts of paroxetine. In published studies, serum concentrations in infants were undetectable (<2 ng / ml) or very low (<4 ng / ml). These children presented no signs of drug effect. However, paroxetine should not be used during lactation unless the potential benefit to the mother justifies the potential risk to the child.

Updated:16.04.08