May 27 2022




Recommendations

There is limited information on the effects of this medication during breastfeeding. Published studies generally refer very small number of observations, which not allow to extrapolate the results to the whole population.

If possible, quetiapine should be replaced during breastfeeding for another antipsychotic, because of potential adverse effects that may have and are not known.

Of the cases reported, it appears that quetiapine in limited quantity passes into breast milk, usually showing good tolerance, especially at daily doses below 400 mg. However, it should be noted that a significant proportion of mothers receiving quetiapine also were taking other medications, especially antidepressants, anxiolytics and antipsychotics, which probably played a role in the little-known observations adverse effects.

Some authors consider that the amount of the substance ingested by the baby does not exceed 0.1% of the dose administered to the mother.In the worst-case scenario, this figure could reach 0.5% when the mother took the maximum dose. Some measurements estimate that with a maternal dose of 400 mg daily of quetiapine, the infant may receive 0.1 mg/kg/day of the substance. In a case where the mother received 400 mg daily, the level of medication in the baby reached 6% of the maternal blood level.

It has been published a case of galactorrhea in patients who breastfed her baby while taking quetiapine.

Warning of the manufacturer:

It is unknown the degree to which quetiapine is excreted in human milk. Is therefore advisable avoid breast-feeding during treatment with quetiapine

Updated:29.02.08