May 22 2022


The limited information available suggests that, at rates not exceeding 6 mg daily, the substance reaches a tolerable level in most of infants exclusively breastfed. Despite the latter, it is surely preferable to use an alternative drug.

It is estimated that an exclusively breastfed infant would receive an amount less than 5% of the dose given to the mother, mostly in the form of OH-risperidone, an active metabolite. The drug concentration in the baby could be undetectable in most cases. No adverse effects have been published in children exposed to risperidone through breastfeeding, although these data do not allow be optimistic, given the limitations of the available studies.

This substance rises prolactinemia which can cause gynecomastia and galactorrhea in some patients.

Warning of the manufacturer:

It is unknown whether risperidone is excreted in human milk. In animal studies, risperidone and 9-hydroxy-risperidone are excreted in human milk. Consequently, this drug should not be administered to women during lactation.