August 13 &

ACETAZOLAMIDE

List of brands containing acetazolamide   

This page contains list of brands of authorized pharmaceutical specialties of the active principle acetazolamide in the countries listed below:

Australia] [ Brazil] [ Canada] [ France] [ Germany] [ India] [ Italy] [ Japan] [ Mexico] [ Pakistan] [ Puerto Rico] [ Spain] [ Turkey] [ United Kingdom] [ U.S.A]

Given the nature of the pharmaceutical market, some specialties may be unavailable, have been removed from the pharmaceutical market or have changed its name. So that, in no case can take decisions based on the information contained in the page. MEDIZZINE is not responsible for any damage arising from the information provided, which may be incomplete or outdated.

Indications and usage     

Acetazolamide reduces the formation of hydrogen ions (H +) and bicarbonate (CO3H-) from carbon dioxide and water by inhibiting the enzyme carbonic anhydrase which catalyzes this conversion, reducing the availability of ions to be transported to organic liquids. The result of drug action is the reduction of liquid in various tissues.

For this property, acetazolamide decreases the secretion of aqueous humor in the eye, reducing the intraocular pressure, elevated in cases of glaucoma. Its effect may be useful in certain disorders of the central nervous system such as epilepsy, by delaying the neuronal discharge characteristic of this disease. The action on the kidney has a diuretic effect, eliminating water, sodium, and potassium.

It is indicated in certain forms of glaucoma, as the simple chronic open-angle glaucoma, secondary glaucoma, and preoperatively narrow-angle glaucoma when the reduction of intraocular pressure is necessary.

It is also indicated as an aid in the liquid retention of congestive heart failure or induced by medicinal substances or drugs, certain forms of epilepsy especially in petit mal, grand mal seizures, mixed type convulsions and myoclonus, both children and adults.

Acetazolamide is also indicated in the prevention and treatment of symptoms associated with altitude sickness, also called acute mountain sickness, as in the case of climbers attempting a climb in a short time and in subjects very susceptible to this disorder although the climbing is done slowly.

Medizzine recommends consulting your doctor if you are unsure (or you do not know) why you have been given acetazolamide.

Other ingredients of available commercial presentations:

Capsules:

The ingredients include gelatin, titanium dioxide, propylene glycol, iron oxide, and dyes.

Tablets:

Tablets incorporating dibasic calcium phosphate, corn starch, sodium starch glycolate, povidone and magnesium stearate

Injectable solution:

Each vial contains acetazolamide sodium equivalent to 500 mg acetazolamide as the active ingredient (50 mg/ml). The excipients include sodium hydroxide and hydrochloric acid (for pH adjustment.), and water for injection.

Warning:

The composition of the various presentations may vary from one country to another. We recommend you consult the information provided by your local supplier.

Before taking the drug     

Do not use acetazolamide

If you are allergic (hypersensitive) to acetazolamide, to other sulfonamides and/or its derivatives or any of the other ingredients of the medicinal product prescribed to you. If you think may be allergic, ask your doctor.

Allergy symptoms may include:

- Asthma attacks with shortness of breath, audible wheezing or rapid breathing.
- More or less sudden swelling of the face, lips, tongue or elsewhere in the body. It is especially critical if it affects the vocal cords.
- Hives, itching, rash
- Anaphylactic shock (loss of consciousness, paleness, sweating, etc.).

Nor you should take this medicine:

- If you have low sodium levels (hyponatremia) or potassium (hypokalemia) in the blood,
- If you have a major liver or kidney disease. In the case of having liver cirrhosis, can be induced the appearance of a hepatic encephalopathy
- If you suffer from adrenal insufficiency (Addison's disease),
- If you have a metabolic disorder called hyperchloraemic acidosis,
- If you are pregnant or breastfeeding your baby.

Take special care with acetazolamide

- In the case of chronic narrow-angle glaucoma, you should not use this medicine for prolonged periods as the reduction of intraocular pressure can allow angle closure and worsening of glaucoma can occur.
- If you have or have had kidney stones (nephrolithiasis)
- If you have bronchopulmonary problems such as chronic bronchitis or emphysema, which may cause difficulty breathing,
- If you are 65 years or older,
- A small number of people being treated with antiepileptic drugs, as well as with acetazolamide have thoughts of self-harm or even suicide. If you experience such thoughts, report it immediately to your doctor,
- Acetazolamide can modify certain lab tests. If you require some analysis, you should tell your doctor you are taking acetazolamide.

Consult your doctor, if any of the above circumstances had ever happened.

Remember that your doctor has prescribed this medicine only for you. Never give it to someone else.

If in doubt, consult your doctor.

Taking other medicines

Tell your doctor or pharmacist if you are taking or have recently taken any other medicines, including herbal products or drugs obtained without a prescription. <

Acetazolamide can modify the effects of some of these medicines and vice-versa:

- Medicines to treat heart disease, such as cardiac glycosides, eg digoxin,
- Medications for high blood pressure,
- Anticoagulant (warfarin, acenocoumarol)
- Oral antidiabetic drugs such as metformin or gliclazide
- Medicines to treat seizures, including epilepsy. Acetazolamide can raise or lower the levels of certain anticonvulsants (phenytoin, primidone, topiramate or carbamazepine)
- folic acid antagonist drugs such as methotrexate or trimethoprim
- Corticosteroids, such as cortisone or prednisone
- Amphetamines, whose effect can be increased or extended,
- Other carbonic anhydrase inhibitors such as dorzolamide or brinzolamide, used locally for glaucoma,
- Ɓacetylsalicylic acid (aspirin®) and its derivatives.
- Antiarrhythmic drugs such as quinidine, whose elimination are slowed by acetazolamide and may increase its effects,
- Methenamine, a substance to prevent urinary tract infections, whose effect can be counteracted by acetazolamide
- Lithium carbonate, a drug for severe depressive disorders, the elimination of which is favored by acetazolamide
- Sodium bicarbonate, a corrector of acidosis for IV use, whose joint use favors appearing kidney stones. Also, should be taken into account the consumption by own initiative for heartburn.
- Cyclosporine, an immunosuppressive agent, commonly used for transplant rejection treatment, whose levels may be elevated by acetazolamide.

Use with food and beverages

Food does not interfere with the absorption of this drug, so you can take it before, during or after meals.

Special physiological situations

Pregnancy and lactation:

Always consult your doctor or pharmacist before taking any medicine during pregnancy or breastfeeding.

Studies in laboratory animals have identified malformations and embryotoxicity at high doses. There are no adequate and well-controlled studies on the use of this medicine in pregnant women. For this reason, there are no conclusive data on the safety of its use during pregnancy, so it is not advisable to use, especially during the first trimester.

Acetazolamide passes into breast milk, although it probably does in small quantity. The use of the drug during lactation is justified only if the potential benefit to the mother outweighs the potential risks to the baby. Do not take this medicine if you are breastfeeding your child unless your doctor tells you so.

Elderly:

This drug should be used with caution in patients over 65 years. In the elderly with reduced renal function, metabolic acidosis may occur.

Driving and using machines

Acetazolamide can make some patients feel confused or sleepy, especially when starting treatment or when increasing the dose. Other patients may experience impaired vision. Before driving or operating machinery, you should check how to affect you acetazolamide. If you feel any of the symptoms listed, you should refrain from carrying out these tasks and consult with your doctor.

Consult your doctor or pharmacist before taking any medicine.

How to use acetazolamide     

Follow carefully instructions of use of acetazolamide provided by your doctor. Consult your doctor or pharmacist when in doubt. Follow the instructions of the physician in preference to those given in this website, which may be different. Ask your doctor to explain any aspect that you do not understand, contained in the instruction leaflet that comes with the medicine.

The dose will be established by the doctor in a personalized way for each patient so that the doses expressed here only reflect the usual dosages, which may not be the prescribed dosage to you by your doctor.

Glaucoma: Adult dose usually ranges from 250 mg (a tablet) and 1000 mg (4 tablets) each day, divided into three or more times.

Epilepsy: The usual treatment for children is 8-30 mg/kg/day, not to exceed 750 mg a day. As in the previous case, the total daily amount should be distributed into three or more doses. In adults, the dosage is similar to glaucoma, 250-1000 mg daily.

Fluid retention: In the edema consecutive to a congestive heart failure or induced by substances, the usual starting treatment is 250-375 mg per day, in a single dose at morning, readjusting the dose according to the response.

Altitude sickness (acute mountain sickness): The usual daily dose in adults is 500-1000 mg, divided into three or more times. If it is anticipated the need to rapidly ascend to high altitude (rescues, etc.), usually are used the highest recommended dose if possible, from one or two days before the ascent. Treatment should continue for 48 hours or more to control symptoms if the patient remains at high altitude.

Renal failure: Acetazolamide is contraindicated in patients with severe renal failure (GFR below 10 ml/min). In patients with moderate to severe renal impairment, the dose should be reduced by half or increase the interval between doses, eg, taking the drug every twelve hours instead of every six or eight hours .

Elderly: Usually, the dose in the elderly should be established with caution. The treatment should start with the lowest effective dose possible since elderly patients suffer frequently an impaired kidney or liver function and is common the occurrence of other disorders .

WARNING: Increase the dose of acetazolamide does not increase the patient's improvement, especially the amount of urine, although it may increase the incidence of drowsiness and/or paresthesia (tingling or other sensations). Conversely, increasing the dose often decreases the amount of urine, although in severe cases it may be necessary.

Before and during treatment, your doctor can control how acetazolamide influences on your health through blood tests, especially the number of white, red cells and platelets, and electrolytes (sodium, potassium).

If you think the effect of the medicine is too strong or too weak, consult your doctor.

If you have any further questions on the use of this product, ask your doctor or pharmacist.

While you take acetazolamide     

If a doctor prescribes another medicine, tell you are taking acetazolamide.

Check with your doctor regularly developments of disorder that motivates the use of acetazolamide. Maybe there is some reason that prevented you properly receive the indicated doses and induce your doctor to erroneous conclusions about treatment.

Do not restart treatment with acetazolamide at your own risk without first talking to your doctor, nor encourage its use by another person, even if have the same symptoms you have. Nor is it advisable to interrupt or reduce the dose without considering the opinion of your doctor.

If you feel unwell during treatment with acetazolamide, immediately consult your doctor.

If you take more than you should:

In the case of overdose or accidental ingestion, consult the Toxicology Information Service in your country, immediately consult your doctor or pharmacist or go to the emergency room of the nearest hospital. Take the pack and the rest of unconsumed medicine.

If you forget to take acetazolamide

Take it as soon as you remember. However, if remain only two hours or less until the next dose, skip the dose you had forgotten and continue taking this medication as your doctor has told you.

Do not take a double dose to make up for forgotten individual doses.

If you stop taking acetazolamide

Do not stop treatment unless your doctor tells you so. This medicine is used for important diseases, which could get worse if you stop taking acetazolamide.

If you have any further questions on the use of this product, ask your doctor or pharmacist.

Side Effects of acetazolamide     

Like all medicines, acetazolamide can cause side effects although not everybody gets them.

The frequency of side effects is classified into:

Very common: affect 1 out of 1-10 patients
Common: affect 1 out of 10-100 patients
Uncommon: affect 1 out of 100-1.000 patients
Rare: affect 1 out of 1.000-10.000 patients
Very Rare: affect less than 1 in 10,000 patients
Incidence not known: Can not be established the true incidence from the available data

Common side effects:

- Headaches,
- Diarrhea,
- Malaise, loss of appetite, thirst, metallic taste,
- Dizziness, loss of limbs control ,
- Hot flashes,
- Need to urinate often,
- Tiredness, irritability, hyperexcitability,
- Tingling or numbness in the fingers or toes and coldness of the extremities.

Uncommon side effects:

- Depression ,
- Drowsiness or confusion,
- Loss of sexual appetite,
- tinnitus or difficulty for hearing,
- Transient myopia which improved by reducing the dose or stop treatment.

Rare and very rare side effects:

Although rarely, there have been observed severe reactions to sulfonamides, including Stevens-Johnson syndrome and toxic epidermal necrolysis, fulminant hepatic necrosis, anaphylaxis, agranulocytosis, aplastic anemia, and other blood dyscrasias that occasionally can be fatal.

Hypersensitivity reactions may recur when a sulfonamide is taken again, regardless of the route of administration. If signs of hypersensitivity or other serious reactions occur, stop treatment and consult your doctor. Even when a mild rash appears, you should consult your doctor as soon as possible.

Acetazolamide can lead to unexpected allergic reactions, even if the patient lacks from a previous reaction to acetazolamide because this substance may have an allergic cross-reaction with other sulfonamides. Fortunately, severe reactions are very rare. If you notice wheezing and/or shortness of breath, swelling of the eyelids, face or lips, rash or itching (especially if it affects the whole body) should consult with your doctor immediately.

Acetazolamide can lead to photosensitivity reactions. If you suffer rashes, related or not to exposure to the sun or ultraviolet radiation, consult your doctor.

Patients receiving high doses of acetylsalicylic acid or its derivatives together with acetazolamide may have a greater or lesser degree of metabolic acidosis with symptoms such as anorexia, tachypnea, and lethargy, which may lead in exceptional cases to coma and even death of the patient.

Very rarely, acetazolamide may affect the blood and patient may be more prone to infections or to have blood clotting problems. If you have a sore throat or fever or bruising or small red spots on the skin should tell your doctor immediately. If you experience muscle weakness or seizures, you should consult your doctor immediately.

Very rarely, this medicine can affect the liver or kidney. If you have back pain, pain or burning during urination, difficulty urinating or interrupted stream of urine, blood in the urine or stool, stools with little color (whitish) or are black or tarry or you have a yellowish of conjunctive eye or skin (jaundice), you should tell as soon as possible to your doctor.

Prolonged use of acetazolamide can lead to kidney stone formation and can cause osteomalacia. Sometimes the drug can alter the level of blood glucose, resulting in either a higher or lower glucose level than normal.

This list does not include all adverse reactions associated with the use of acetazolamide, both well established as those that are under consideration or confirmation. In case you feel unwell, should immediately consult with the doctor who prescribed this medicine.

If you notice any side effects not listed in this website or in the leaflet accompanying the package, ask your doctor or pharmacist.

If any of the side effects gets serious, tell your doctor or pharmacist.

List of brands containing acetazolamide     

This page contains list of brands of authorized pharmaceutical specialties of the active principle acetazolamide in the countries listed below:

Australia] [ Brazil] [ Canada] [ France] [ Germany] [ India] [ Italy] [ Japan] [ Mexico] [ Pakistan] [ Puerto Rico] [ Spain] [ Turkey] [ United Kingdom] [ U.S.A]

Given the nature of the pharmaceutical market, some specialties may be unavailable, have been removed from the pharmaceutical market or have changed its name. So that, in no case can take decisions based on the information contained in the page. MEDIZZINE is not responsible for any damage arising from the information provided, which may be incomplete or outdated.

Warning:

With exceptions expressly indicated, these lists do not include active principle associations with other drugs or clinical use containers.

Australia:     

DIAMOX 250 mg, 100 tablets
GLAUMOX 50 mg/ml, powder for 10 ml injectable soluition

Brazil:     

DIAMOX 250 mg, 25 tablets

Canada:     

ACETAZOLAM 250 mg, tablets
ACETAZOLAMIDE AA PHARMA 250 mg, 100 tablets
ACETAZOLAMIDE STERIMAX 50 mg/ml, powder for 10 ml injectable soluition

France:     

DIAMOX 250 mg, 24 tablets
DIAMOX 50 mg/ml, powder for 10 ml injectable soluition

Germany:     

ACEMIT 250 mg, 20-30-100 tablets
DIAMOX 250 mg 30-100 tablets
DIAMOX 50 mg/ml, powder for 10 ml injectable soluition
GLAUPAX 250 mg, 10-30-40-100 tablets

India:     

ACETAMIDE 250 mg, tablets
ACETAMIN 250 mg, tablets
ACETARIV 250 mg, tablets
AVVA 250 mg, tablets
AVVA 250 mg, extended release capsules
DIAMOX 250 mg, tablets
LOPAR-SR 250 mg, extended release capsules
SYNOMAX 250 mg, tablets
ZOLAMIDE 250 mg , tablets

Italy:     

DIAMOX 250 mg, 12 tablets

Japan:     

DIAMOX 250 mg, tablets

Mexico:     

ACETADIAZOL 250 mg, 30 tablets
DIAMOX 50 mg/ml, powder for 10 ml injectable soluition

Pakistan:     

ACEMOX 250 mg, tablets
AZM 250 mg, tablets
EVAMOX 250 mg, tablets
SETACAR 250 mg, tablets

Spain:     

EDEMOX 250 mg, 20 tablets

Turkey:     

DIAZOMID 250 mg, 10 tablets

United Kingdom:     

ACETAZOLAMIDE AMDIPHARM MERCURY 250 mg, 112 tablets
DIAMOX 250 mg, 112 tablets
DIAMOX 50 mg/ml, powder for 10 ml injectable soluition
DIAMOX SR 250 mg, 30 modified-release capsules
EYTAZOX 250 mg, 30 prolonged-release capsules

U.S.A. and Puerto Rico:     

ACETAZOLAMIDE SAGENT PHARMA 50 mg/ml, powder for 10 ml injectable soluition
ACETAZOLAMIDE AVKARE 250 mg, 90 tablets
ACETAZOLAMIDE AMERICAN HEALTH PACK 500 mg, 30 prolonged-release capsules
ACETAZOLAMIDE BARR LAB 500 mg, 100 prolonged-release capsules
ACETAZOLAMIDE HERITAGE PHARMA 500 mg, 100 prolonged-release capsules
ACETAZOLAMIDE KAISER FOUND HOSP 500 mg, 30 prolonged-release capsules
ACETAZOLAMIDE ZYDUS 500 mg, 100 prolonged-release capsules
ACETAZOLAMIDE BEDFORD50 mg/ml, powder for 10 ml injectable soluition
ACETAZOLAMIDE X-GEN PHARMA50 mg/ml, powder for 10 ml injectable soluition
ACETAZOLAMIDE A-S MEDICATION SOLUTIONS 125 mg, 12 tablets
ACETAZOLAMIDE A-S MEDICATION SOLUTIONS 250 mg, 12 tablets
ACETAZOLAMIDE AMERICAN HEALTH PACK 250 mg, 100 tablets
ACETAZOLAMIDE CARDINAL HEALTH 250 mg, 10 & 100 tablets
ACETAZOLAMIDE GOLDEN STATE MED SUPP 125 mg, 100 tablets
ACETAZOLAMIDE GOLDEN STATE MED SUPP 250 mg, 100 tablets
ACETAZOLAMIDE LANNETT 250 mg, 100 tablets
ACETAZOLAMIDE NCS HEALTHC OF KY 250 mg, 30 tablets
ACETAZOLAMIDE PD-RX PHARMA 125 mg, 12 tabletas
ACETAZOLAMIDE PD-RX PHARMA 250 mg, 24 tablets
ACETAZOLAMIDE PHYSICIANS TOTAL CARE 250 mg, 12, 15, 20 & 60 tablets
ACETAZOLAMIDE REDPHARM 250 mg, 56 tablets
ACETAZOLAMIDE REMEDYREPACK 250 mg, 30 tablets
ACETAZOLAMIDE TARO 125 mg, 100 tablets
ACETAZOLAMIDE TARO 250 mg, 100 tablets
DIAMOX SEQUELS 500 mg, 30 &100 extended-release capsules

Page updated: October 11, 2010.