February 28 2020

PENTOXIFYLLINE

List of brands containing pentoxifylline   

This page contains list of brands of authorized pharmaceutical specialties of the active principle pentoxifylline in the countries listed below:

Australia] [ Brazil] [ Canada] [ France] [ Germany] [ India] [ Italy] [ Japan] [ Mexico] [ Pakistan] [ Puerto Rico] [ Spain] [ Turkey] [ United Kingdom] [ U.S.A]

Given the nature of the pharmaceutical market, some specialties may be unavailable, have been removed from pharmaceutical market or have changed its name. So that, in no case can take decisions based on the information contained in the page. MEDIZZINE is not responsible for any damage arising from the information provided, which may be incomplete or outdated.

Indications and usage     

Pentoxifylline is a peripheral vasodilator drug. Increases the elasticity of red blood cells, inhibits the aggregation of the red cells and platelets and decreases blood viscosity, promoting blood circulation.

Pentoxifylline is indicated in the treatment of disorders of peripheral circulation, such as:

- Blood flow abnormalities of extremities (leg pain when walking and resting),
- Night cramps in the calves, tingling and numbness in the legs and arms),
- Ulcers (sores) in the legs and gangrene.

Medizzine recommends consult your doctor if you are unsure (or you do not know) why you have been given pentoxifylline.

Other ingredients of available commercial presentations:

Each tablet contains 400 or 600 mg pentoxifylline. The other ingredients may vary from one to another brand and may include: Hypromellose, microcrystalline cellulose, crospovidone, colloidal silicic anhydride, magnesium stearate, macrogol 6000, titanium dioxide, talc, 30% polyacrylate, carnauba wax, lactose, triacetin, erythrosine and indigo-carmine aluminum lake.

A 15 ml vial contains 300 mg pentoxifylline (INN) . As excipients, sodium chloride and water for injection.

Warning:

The composition of the various presentations may vary from one country to another. We recommend you consult the information provided by your local supplier.

Important information     

This medicine in tablets contain lactose. If your doctor has told you have an intolerance to some sugars, contact himr before taking it.

Before taking the drug     

Do not use pentoxifylline

If you are allergic (hypersensitive) to pentoxifylline or any of the other ingredients of the medicinal product prescribed to you. If you think may be allergic, ask your doctor.

Allergy symptoms may include:

- Asthma attacks with shortness of breath, audible wheezing or rapid breathing.
- More or less sudden swelling of face, lips, tongue or elsewhere in the body. It is especially critical if it affects the vocal cords.
- Hives, itching, rash
- Anaphylactic shock (loss of consciousness, paleness, sweating, etc.).

Nor you should take this medicine:

If you have severe bleeding or a severe retinal bleeding caused by diseases such as diabetes and high blood pressure.
If you have recently had a myocardial infarction

Take special care with pentoxifylline

- If you have severe heart rhythm disturbances
- Myocardial infarction,
- Arterial hypotension,
- Severe liver disease
- Severe kidney disease
- Increased tendency to bleeding due to anticoagulant medication or coagulation disorders

If in doubt, consult your doctor.

Taking other medicines

Tell your doctor or pharmacist if you are taking or have recently taken any other medicines, including herbal products or drugs obtained without a prescription.

Especially, tell your doctor or pharmacist if you are taking:

When administered simultaneously pentoxifylline and antihypertensive, may be required adjusting the dose individually; therefore, must inform your doctor if are taking any blood pressure medicine.

Treatment with pentoxifylline in patients treated with diabetes medications (insulin or oral agents) can enhance the effect of these, so you must inform the doctor if are taking medicine for diabetes.

Similarly, simultaneous treatment of pentoxifylline and theophylline may cause a rise in theophylline levels and thereby increase the side effects of it, so also will need to tell your doctor if you are taking any medication containing theophylline.

Use with food and beverages

This medicine must swallow whole with some liquid (about half a glass of water) during or shortly after a meal.

Consult your doctor or pharmacist before taking any medicine.

Special physiological situations

Pregnancy and lactation

In case of pregnancy you should not use this medicine.

If you are lactating, should take into consideration that pentoxifylline passes into breast milk in small amounts. Consult your doctor before taking this drug to assessing the appropriateness of continuing or not treatment.

Children

Do not administer this drug to children.

Driving and using machines

It has not been reported any negative effect of pentoxifylline on the ability to drive car or operate machinery.

Consult your doctor or pharmacist before taking any medicine.

How to use pentoxifylline     

Follow exactly instructions of use of pentoxifylline provided by your doctor. Consult your doctor or pharmacist when in doubt. Follow the instructions of the physician in preference to those given in this website, which may be different. Ask your doctor to explain any aspect that you do not understand, contained in the instruction leaflet that comes with the medicine.

It is important to tell your doctor about any illness you suffer, as it could be useful to determine the correct dosage for you.

Your doctor will tell you how long your treatment with pentoxifylline. Do not stop treatment early because you would not get the desired therapeutic effect.

Do not take more medicine than your doctor has recommended.

Swallow the tablet whole with some liquid during or shortly after meals.

Oral dosage for adults and elderly patients:

One tablet of pentoxifylline two or three times a day, depending on the prescribed dosage form , which means a daily maximum two 600-mg tablets or three 400-mg tablets (1200 mg pentoxifylline).

Follow your doctor's instructions regarding the number of tablets you should take and how often, since the dose is decided according to the nature and severity of the disease and the tolerance of each patient.

Dosage for intravenous administration:

It is recommended to administer an infusion of 100-600 mg pentoxifylline once or twice a day. The infusion may be supplemented by oral treatment with 400 mg tablets, resulting the total daily dose 1200 mg pentoxifylline

In advanced cases, particularly in patients with severe pain at rest, gangrene or ulcer, may be administered both a continuous intravenous infusion of up to 1200 mg in 24 hours, as two infusions of 600 mg each during at least 6 hours.

Should not exceed the maximum dose of 1200 mg of pentoxifylline for 24 hours.

The infusion time must be at least 60 minutes for each 100 mg pentoxifilina. It is important you tell your doctor about any illness you suffer, since it could be useful to determine the correct dosage for you.

If you have a severe kidney or liver disease, your doctor will reduce the dose, adjusting it depending on the disease and your drug tolerance.

If you have low blood pressure or are prone to it, or have a disease for which a decrease in blood pressure could be harmful, such as severe coronary heart disease or stenosis, your doctor will prescribe a low initial dose that will increase gradually, according to your improvement degree.

If you think the effect of the medicine is too strong or too weak, consult your doctor.

If you have any further questions on the use of this product, ask your doctor or pharmacist.

While you take pentoxifylline     

If a doctor prescribes another medicine, tell you are taking pentoxifylline.

Check with your doctor regularly developments of disorder that motivates the use of pentoxifylline. Maybe there is some reason that prevented you properly receive the indicated doses and induce your doctor to erroneous conclusions about treatment.

Do not restart treatment with pentoxifylline at your own risk without first talking to your doctor, nor encourage its use by another person, even if have the same symptoms you have. Nor is it advisable to interrupt or reduce the dose without considering the opinion of your doctor.

If you feel unwell during treatment with pentoxifylline, immediately consult your doctor.

If you take more than you should:

If you accidentally take more pentoxifylline than you should, may experience nausea, dizziness, palpitations or a drop in blood pressure. Also can occur fever, tremors, hot flashes, loss of reflexes, seizures, skin rashes, vomiting that looks like coffee grounds and unconsciousness.

If you experience these symptoms, consult your doctor or pharmacist immediately or call the National Poisons Information Service in your country. If you have taken a pentoxifylline overdose, go to the emergency department of the nearest hospital. Take the container with you, even if it is empty

If you forget to take pentoxifylline

Do not take a double dose to make up for a forgotten dose.

If you have any further questions on the use of this product, ask your doctor or pharmacist.

Side Effects of pentoxifylline     

Like all medicines, pentoxifylline can cause side effects, although not everybody gets them.

The frequency of side effects is classified into:

Very common: affect 1 out of 1-10 patients
Common: affect 1 out of 10-100 patients
Uncommon: affect 1 out of 100-1.000 patients
Rare: affect 1 out of 1.000-10.000 patients
Very Rare: affect less than 1 in 10,000 patients
Incidence not known: Can not be established the true incidence from the available data

When taking high doses pentoxifylline,occasionally may occur:

- Hot flushes,
- Gastrointestinal disorders such as stomach pressure, bloating, nausea, vomiting or diarrhea,
- Heart rhythm disturbances (eg .: palpitations).

This list not includes all adverse reactions associated with the use of pentoxifylline, both well established as those that are under consideration or confirmation. In case you feel unwell, should immediately consult with the doctor who prescribed this medicine.

If you notice any side effects not listed in this website or in the leaflet accompanying the package, ask your doctor or pharmacist.

If any of the side effects gets serious, tell your doctor or pharmacist.

List of brands containing pentoxifylline     

This page contains list of brands of authorized pharmaceutical specialties of the active principle pentoxifylline in the countries listed below:

Australia] [ Brazil] [ Canada] [ France] [ Germany] [ India] [ Italy] [ Japan] [ Mexico] [ Pakistan] [ Puerto Rico] [ Spain] [ Turkey] [ United Kingdom] [ U.S.A]

Given the nature of the pharmaceutical market, some specialties may be unavailable, have been removed from pharmaceutical market or have changed its name. So that, in no case can take decisions based on the information contained in the page. MEDIZZINE is not responsible for any damage arising from the information provided, which may be incomplete or outdated.

Warning:

With exceptions expressly indicated, these lists do not include active principle associations with other drugs or clinical use containers.

Australia:     

TRENTAL 400 mg, controlled release tablets

Brazil:     

CHEMOPENT 400 mg, 20 tablets
PENTOX 20 mg/ml, ampoules with 5 ml of solution for infusion
PENTOXIFILINA EMS 400 mg, 20, 30 and 60 tablets
PENTOXIFILINA GERMED 400 mg, 20 and 30 tablets
PENTOXIFILINA SANOFI-AVENTIS 400 mg, 20 and 30 tablets
PENTOXIFILINA BIOSINTETICA 400 mg, 30 tablets
PENTOXIN 400 mg, 20 tablets
PENTRAL 400 mg, 10 and 20 tablets
PENTRAT 400 mg, 20 tablets
PERENTAL 400 mg, 50 tablets
TRENTAFILINA 400 mg, 20 and 30 tablets
TRENTAFILINA 400 mg, 20 tablets
TRENTAL 20 mg/ml, ampoules with 5 ml of solution for infusion
TRENTAL 400 mg, 20 dragees
TRENTAL 600 mg, 20 tablets
TRENTAL 400 mg, 15 and 20 extended-release tablets
VASCER 20 mg/ml, ampoules with 5 ml of solution for infusion
VASCER 400 mg, 20 tablets

Canada:     

APO-PENTOXIFYLLINE SR 400 mg, 100 extended-release tablets
NU-PENTOXIFYLLINE-SR 400 mg, 100 extended-release tablets
TRENTAL 400 mg, 60 extended-release tablets

France:     

PENTOFLUX LP 400 mg, extended-release tablets
PENTOXIFYLLINE BIOGARAN LP 400 mg, extended-release tablets
PENTOXIFYLLINE EG LP 400 mg, extended-release tablets
PENTOXIFYLLINE MYLAN LP 400 mg, extended-release tablets
PENTOXIFYLLINE QUALIMED LP 400 mg, extended-release tablets
PENTOXIFYLLINE RATIOPHARM LP 400 mg, extended-release tablets
PENTOXIFYLLINE SANDOZ LP 400 mg, extended-release tablets
PENTOXIFYLLINE TEVA L.P. 400 mg, extended-release tablets
TORENTAL LP 400 mg, extended-release tablets

Germany:     

CLAUDICAT 400 mg, extended-release tablets
CLAUDICAT 600mg extended-release tablets
DURAPENTAL 400 mg, extended-release tablets
PENTOHEXAL 300 mg/15 ml, solution for infusion
PENTOHEXAL 400, 400 mg extended-release tablets
PENTOHEXAL 600, 600 mg extended-release tablets
PENTOHEXA 100 mg/5 ml,, solution for infusion
PENTOX-CT 300 mg,, solution for infusion
PENTOX-CT 600 mg extended-release tablets
PENTOXIFYLLIN ABZ 600 mg extended-release tablets
PENTOXIFYLLIN AL 600 rmg extended-release tablets
PENTOXIFYLLIN SANDOZ 400 mg, extended-release tablets
PENTOXIFYLLIN SANDOZ 600 mg, extended-release tablets
PENTOXIFYLLIN STADA 600 mg, extended-release tablets
PENTOXIFYLLIN-RATIOPHARM 300 mg/15 ml solution for infusion
PENTOXIFYLLIN-RATIOPHARM 400 mg, extended-release tablets
PENTOXIFYLLIN-RATIOPHARM 600 mg, extended-release tablets
RENTYLIN 400 mg, extended-release tablets
RENTYLIN 100 mg/5 ml, solution for infusion
TRENTAL 100 mg/5 ml, solution for infusion
TRENTAL 300 mg, solution for infusion
TRENTAL 400 mg, extended-release tablets
TRENTAL 600 mg, extended-release tablets

India:     

FLEXITAL 400 mg, extended-release tablets
FLEXITAL 20 mg/mL, 15 ml solution for infusion
KINETAL 400 mg, extended-release tablets
KINETAL 20 mg/mL, 15 ml solution for infusion
PENTOVAS 400 mg, extended-release tablets
RB FLEX 400 mg, extended-release tablets
RB FLEX 20 mg/mL, 15 ml solution for infusion
TRENTAL 20 mg/mL, 5 AND 15 ml solution for infusion
TRENTAL 400 mg, extended-release tablets

Italy:     

TRENTAL 400 mg, 10 and 30 extended-release tablets
TRENTAL 20 mg/ml, 5 ml solution for infusion

Japan:     

N/A

Mexico:     

ARTELIFE 400 mg, 30extended-release tablets
CIRAPER 400 mg,extended-release tablets
DILAPRINAF 400 mg,extended-release tablets
DILAPRINAF 600 mg,extended-release tablets
DUPLAT 400 mg, 30 and 60 extended-release dragees
EUROTOFI 400 mg, 30 extended-release dragees
FIXOTEN 400 mg, 30 extended-release dragees
KENTADIN 400 mg, 30 extended-release dragees
KENTADIN I 20 mg/ml, 15 ml solution for infusion
OXILAC 400 mg,extended-release tablets
PENSIRAL 400 mg, 30 tablets
PENTOXIFILINA APOTEX 400 mg, 30 extended-release dragees
PERIDANE 400 mg, 30 extended-release dragees
SINSUFYVA 400 mg, 30 extended-release tablets
SUFISAL 400 mg, 10 and 30 extended-release dragees
SUFISAL 600 mg, 20, 30, 60 and 90 extended-release dragees
TECXIFIL 400 mg, 30 tablets
TRENTAL 400 mg, 30, 60 and 90 extended-release dragees
TRENTAL 600 mg, 20, 30, 60 and 90 extended-release dragees
TRENTAL 20 mg/ml, 15 ml solution for infusion
VANTOXYL 400 mg, 30 extended-release tablets
VASOFYL 400 mg, 30 and 120 extended-release tablets
XINSOL 10 mg/ml, 15 ml solution for infusion
XIPEN 400 mg, 30 extended-release dragees

Pakistan:     

AGAPURIN 100 mg/5 ml, solution for infusion
AGAPURIN 400 mg, tablets

Spain:     

ELORGAN 400 mg, 60 tablets
HEMOVAS 20 mg/ml, 15 ml solution for infusion
HEMOVAS 400 MG, 60 dragees
HEMOVAS 600 mg, 60 extended-release tablets
NELORPIN 600 mg, 60 extended-release tablets
PENTOXIFILINA ALTER 400 mg, 60 extended-release tablets
PENTOXIFILINA BELMAC 400 mg, 60 tablets
PENTOXIFILINA DAVUR 400 mg, 60 tablets
RETIMAX 400 mg, 60 tablets

Turkey:     

HEMOPENE 20 mg/ml, 5 ml solution for infusion
PENTOX FORT SR 600 mg, 20 extended-release capsules
PENTOX SR 400 mg, 20 extended-release capsules
TRENTAL 20 mg/ml, 5 ml solution for infusion
TRENTAL 20 mg/ml, 15 ml solution for infusion
TRENTAL CR 600 mg, 20 extended-release tablets
TRENTILIN 20 mg/ml, 5 ml solution for infusion
TRENTILIN RETARD 400 mg, 20 tablets
TRENTILIN RETARD 600 mg, 20 tablets
VASOPLAN 20 mg/ml, 5 ml solution for infusion

United Kingdom:     

TRENTAL 400 mg, 90 tablets

U.S.A. and Puerto Rico:     

PENTOXIFYLLINE APOTEX 400 mg, 100 extended-release tablets
PENTOXIFYLLINE BIOVAIL 400 mg, 100 extended-release tablets
PENTOXIFYLLINE IMPAX 400 mg, 100 extended-release tablets
PENTOXIFYLLINE MYLAN 400 mg, 100 extended-release tablets
PENTOXIFYLLINE PLIVA 400 mg, 100 extended-release tablets
PENTOXIFYLLINE WATSON 400 mg, 100 extended-release tablets
PENTOXIL 400 mg, 100 extended-release tablets
TRENTAL 400 mg, 100 extended-release tablets

Page updated: December 13, 2010.