February 28 &

TRIMEBUTINE

List of brands containing trimebutine   

This page contains list of brands of authorized pharmaceutical specialties of the active principle trimebutine in the countries listed below:

Australia] [ Brazil] [ Canada] [ France] [ Germany] [ India] [ Italy] [ Japan] [ Mexico] [ Pakistan] [ Puerto Rico] [ Spain] [ Turkey] [ United Kingdom] [ U.S.A]

Given the nature of the pharmaceutical market, some specialties may be unavailable, have been removed from the pharmaceutical market or have changed its name. So that, in no case can take decisions based on the information contained in the page. MEDIZZINE is not responsible for any damage arising from the information provided, which may be incomplete or outdated.

Indications and usage     

The active ingredient trimebutine is a modulator of gastrointestinal motility with spasmolytic properties, without depressing normal peristalsis of the digestive system. Also, corrects abnormal motility associated with gastrointestinal pain or pain of biliary origin. This medicine promotes stomach emptying, counteracts nausea and vomiting and reduces the contractility of the colon

Trimebutine is indicated for the symptomatic control of the following gastrointestinal motility disorders:

- Gastroesophageal reflux disease (GERD) and secondary throat discomfort,
- Functional non-ulcer dyspepsia , as the symptomatic treatment of abdominal pain and intestinal transit disorders associated with functional disorders of the digestive tract . This includes bloating, slow digestion, stomach pain, nausea and vomiting, heartburn, acid regurgitation, and belching.
- Aches and cramps caused by gastrointestinal spasms,
- Pain and bloating associated with functional bowel disorders, including irritable bowel syndrome (IBS),
- Postoperative intestinal paralysis (postoperative ileus),
- Preparation for diagnostic procedures (radiological and endoscopic) .

The solution for injection is indicated in the pains of digestive or biliary diseases, and patient preparation for radiological and endoscopic examinations.

This medicine should not be used to treat infant colic.

Medizzine recommends consulting your doctor if you are unsure (or you do not know) why you have been given trimebutine.

Other ingredients of available commercial presentations:

Capsules:

Each capsule contains 200 mg of trimebutine maleate equivalent to 154 mg trimebutine. Excipients can include soybean oil, soy lecithin, hydrogenated vegetable oil, gelatin, glycerol, propylparaben, methylparaben, titanium dioxide, and purified water.

Tablets:

Each tablet contains 100 or 200 mg of trimebutine maleate. The excipients may include microcrystalline cellulose, lactose monohydrate, maize starch, povidone, and starch glycolate

Prolonged-release tablets:

In addition to 300 mg trimebutine maleate, excipients may include Methocel E 15 K 100 methocel, lactose, microcrystalline cellulose, povidone, magnesium stearate, and quinoline yellow.

Injectable solution:

In addition to 10 mg/ml trimebutine maleate, excipients include sodium chloride, benzyl alcohol, and water for injections

Powder/granules for oral suspension

In addition to trimebutine maleate at different concentrations, these presentations may contain polysorbate 80, natural aroma of orange (orange essential oil, Arabic gum), orange sunset dye and sucrose

Warning:

The composition of the various presentations may vary from one country to another. We recommend you consult the information provided by your local supplier.

Important information     

Injectable solution:

This product contains 5 mg/ml benzyl alcohol. It can cause toxic reactions and anaphylactoid reactions in infants and children up to 3 years.

This medicine contains 3.85 mmol sodium per dose, which should be considered in patients with reduced sodium diets (salt)

Powder/granules for oral suspension:

The sucrose content should be considered in patients following a low-sugar diet or diabetes. Use of this medicine is not recommended in patients with fructose intolerance, glucose-galactose malabsorption or sucrase/isomaltase deficiency (a rare hereditary disease).

This medicine contains yellow-orange dye (yellow sunset, E-110), which may cause allergic reactions. It can cause asthma, especially in patients with allergy to aspirin.

Capsules:

This medicine may contain soybean oil, which should not be used in patients with allergy to soy.

This medicine may cause allergic reactions (possibly delayed) because it contains methyl and propyl parabens.

Tablets (including retard tablets):

This medicine contains lactose. If your doctor has told you that you have an intolerance to certain sugars, consult him before taking it.

This medicine may contain wheat starch, which is suitable for patients with celiac disease, but should not be used in patients with allergy to wheat (a different disorder than celiac disease).

Before taking the drug     

Do not use trimebutine

If you are allergic (hypersensitive) to trimebutine or any of the other ingredients of the medicinal product prescribed to you. If you think may be allergic, ask your doctor.

Allergy symptoms may include:

- Asthma attacks with shortness of breath, audible wheezing or rapid breathing.
- More or less sudden swelling of the face, lips, tongue or elsewhere in the body. It is especially critical if it affects the vocal cords.
- Hives, itching, rash
- Anaphylactic shock (loss of consciousness, paleness, sweating, etc.).

Nor you should take this medicine:

- If you are in the first trimester of pregnancy ,
- The tablets are not suitable for patients younger than 12 years

Take special care with trimebutine

- If you are in the first trimester of pregnancy ,
The tablets are not suitable for patients younger than 12 years

Remember that your doctor has prescribed this medicine only for you. Never give it to someone else.

If in doubt, consult your doctor.

Taking other medicines

Tell your doctor or pharmacist if you are taking or have recently taken any other medicines, including herbal products or drugs obtained without a prescription.

It may be necessary to change the dose, or in some cases, discontinue one treatment. This applies to all types of drugs, but especially for:

Especially tell your doctor if you are taking or have recently taken:

- Cisapride,
- Procainamide,
- Zotepine.

Use with food and beverages

It is advisable to take this medicine before meals.

Patients treated with trimebutine should avoid taking alcoholic beverages.

Special physiological situations

Pregnancy and lactation:

Always consult your doctor or pharmacist before taking any medicine during pregnancy or breastfeeding.

Its use is contraindicated during the first trimester of pregnancy. This medicine should be used for the remainder of pregnancy only if, at the discretion of the physician, the potential benefits to the mother clearly outweigh the possible risks to the fetus

Consult with your doctor the advisability of taking trimebutine during lactation. Do not take this medicine on your own initiative without the advice of your doctor.

Children and adolescents

This medicine should not be given to children without proper guidance from the doctor. Do not administer in infant colic.

Elderly

In general, the elderly do not require dose adjustment. However, the physician should evaluate possible organic deterioration of the patient and establish the most appropriate dose for each case.

Driving and using machines

It is not expected that trimebutine can influence the ability to drive or operate machinery.

Consult your doctor or pharmacist before taking any medicine.

How to use trimebutine     

Follow carefully instructions of use of trimebutine provided by your doctor. Consult your doctor or pharmacist when in doubt. Follow the instructions of the physician in preference to those given in this website, which may be different. Ask your doctor to explain any aspect that you do not understand, contained in the instruction leaflet that comes with the medicine.

Granules/powder for oral suspension

Adults:

The usual dose is 200 to 600 mg a day, divided into 3 doses.

Children:

6-12 mg/kg/day divided into 3 doses.

It is advisable to take the suspension 20 minutes before each main meal.

The maximum individual dose is 200 mg (15 ml).

Injectable solution

This medicine can be administered intramuscularly or intravenously slowly (3-5 minutes) or IV infusion diluted in saline or glucose solution.

Preparation for endoscopy or radiology: 50-100 mg daily, i.m. before the procedure.

In gastrointestinal or biliary painful processes, an injection of trimebutine (50 mg in 5 ml) will be administered during the acute phase, continuing with the drug orally.

Tablets/capsules:

Adults:

The usual dose ranges from 300 to 600 mg per day, divided into two or three doses before meals. The maximum dose is 600 mg a day.

Do not crush or chew the tablets or capsules. Swallow the tablet or capsule with the help of a little water or other nonalcoholic liquid.

Duration of treatment:

The doctor will recommend a limited duration of treatment, usually not exceeding 30 days. The minimum duration of treatment is usually 20 days

If you think the effect of the medicine is too strong or too weak, consult your doctor.

If you have any further questions on the use of this product, ask your doctor or pharmacist.

While you take trimebutine     

If a doctor prescribes another medicine, tell you are taking trimebutine.

Check with your doctor regularly developments of disorder that motivates the use of trimebutine. Maybe there is some reason that prevented you properly receive the indicated doses and induce your doctor to erroneous conclusions about treatment.

Do not restart treatment with trimebutine at your own risk without first talking to your doctor, nor encourage its use by another person, even if have the same symptoms you have. Nor is it advisable to interrupt or reduce the dose without considering the opinion of your doctor.

If you feel unwell during treatment with trimebutine, immediately consult your doctor.

If you take more than you should:

In the case of overdose, drowsiness, fainting, diarrhea and nausea may occur. In this case, tell your doctor immediately or go to the emergency room of the nearest hospital. Take the pack and the rest of unconsumed medicine.

If you forget to take trimebutine

Do not take a double dose to make up the missed dose. Skip the missed dose and continue with the next one as usual.

Effects that occur when treatment is discontinued:

Take the medication as long as instructed by your doctor because the symptoms can become worse.

If you have any further questions on the use of this product, ask your doctor or pharmacist.

Side Effects of trimebutine     

Like all medicines, trimebutine can cause side effects although not everybody gets them.

The frequency of side effects is classified into:

Very common: affect 1 out of 1-10 patients
Common: affect 1 out of 10-100 patients
Uncommon: affect 1 out of 100-1.000 patients
Rare: affect 1 out of 1.000-10.000 patients
Very Rare: affect less than 1 in 10,000 patients
Incidence not known: Can not be established the true incidence from the available data

Trimebutine is a generally well-tolerated medication.

Rare side effects:

- Allergic reactions, including rashes (hives, redness),
- Decay,
- Constipation or diarrhea,
- polyuria (urinate a lot),
- Bloating,
- Stomach pain (epigastric) .

Very rare side effects:

- Headache,
- Dry Mouth,
- Dizziness,
- Vomiting;
- Weakness;
- Drowsiness.

This list does not include all adverse reactions associated with the use of trimebutine, both well established as those that are under consideration or confirmation. In case you feel unwell, should immediately consult with the doctor who prescribed this medicine.

If you notice any side effects not listed in this website or in the leaflet accompanying the package, ask your doctor or pharmacist.

If any of the side effects gets serious, tell your doctor or pharmacist.

List of brands containing trimebutine     

This page contains list of brands of authorized pharmaceutical specialties of the active principle trimebutine in the countries listed below:

Australia] [ Brazil] [ Canada] [ France] [ Germany] [ India] [ Italy] [ Japan] [ Mexico] [ Pakistan] [ Puerto Rico] [ Spain] [ Turkey] [ United Kingdom] [ U.S.A]

Given the nature of the pharmaceutical market, some specialties may be unavailable, have been removed from the pharmaceutical market or have changed its name. So that, in no case can take decisions based on the information contained in the page. MEDIZZINE is not responsible for any damage arising from the information provided, which may be incomplete or outdated.

Warning:

With exceptions expressly indicated, these lists do not include active principle associations with other drugs or clinical use containers.

Australia:     

N/A

Brazil:     

DIGEDRAT 200 mg, 20-30-60 capsules
IRRITRATIL 200 mg, 20 capsules
TRIMEB 200 mg, 20-30-60 capsules
TRIMEBUTINA ALTHAIA 200 mg, 30 tablets
TRIMEBUTINA EUROFARMA 200 mg, 30-60 capsules

Canada:     

MODULON 200 mg, 100 tablets
TRIMEBUTINE AA PHARMA 100 mg, 100 tablets
TRIMEBUTINE AA PHARMA 200 mg, 100 tablets

France:     

DEBRICALM 100 mg, tablets
DEBRIDAT 100 mg, tablets
DEBRIDAT 200 mg, tablets
DEBRIDAT 50 mg/5 ml, injectable solution
DEBRIDAT ENFANT ET NOURRISSON 4,8 mg/ml, granules for oral suspension
DEBRIDAT, granules for oral suspension
DEBRIDAT, sachets granules for oral suspension
TRANSACALM 100 mg, tablets
TRIMEBUTINE RPG 100 mg, tablets
TRIMEBUTINE ACTAVIS 100 mg, tablets
TRIMEBUTINE ACTAVIS 200 mg, tablets
TRIMEBUTINE ALMUS 100 mg, tablets
TRIMEBUTINE ALMUS 200 mg, tablets
TRIMEBUTINE ARROW 100 mg, tablets
TRIMEBUTINE ARROW 200 mg, tablets
TRIMEBUTINE ARROW GENERIQUES 100 mg, tablets
TRIMEBUTINE BIOGARAN 100 mg, tablets
TRIMEBUTINE BIOGARAN 200 mg, tablets
TRIMEBUTINE BIOGARAN CONSEIL 100 mg, tablets
TRIMEBUTINE CRISTERS 200 mg, tablets
TRIMEBUTINE EG 100 mg, tablets
TRIMEBUTINE EG 200 mg, tablets
TRIMEBUTINE EVOLUGEN 200 mg, tablets
TRIMEBUTINE GERDA 200 mg, tablets
TRIMEBUTINE ISOMED 100 mg, tablets
TRIMEBUTINE ISOMED 200 mg, tablets
TRIMEBUTINE MYLAN 100 mg, tablets
TRIMEBUTINE MYLAN 200 mg, tablets
TRIMEBUTINE MYLAN CONSEIL 100 mg, tablets
TRIMEBUTINE PFIZER 100 mg, tablets
TRIMEBUTINE PFIZER 200 mg, tablets
TRIMEBUTINE RANBAXY 200 mg, tablets
TRIMEBUTINE RATIO 100 mg, tablets
TRIMEBUTINE SANDOZ mg, tablets
TRIMEBUTINE SANDOZ 200 mg, tablets
TRIMEBUTINE TEVA 100 mg, tablets
TRIMEBUTINE TEVA 200 mg, tablets
TRIMEBUTINE TEVA SANTE 200 mg, tablets
TRIMEBUTINE ZENTIVA 10 mg, tablets
TRIMEBUTINE ZENTIVA 200 mg, tablets
TRIMEBUTINE ZYDUS 100 mg, tablets
TRIMEBUTINE ZYDUS 200 mg, tablets

Germany:     

N/A

India:     

N/A

Italy:     

DEBRIDAT 150 mg, 20 capsules
DIGERENT 150 mg, 30 capsules
DEBRIDAT 72 mg/15 ml, granules for 250 ml oral suspension
DEBRIDAT 10 mg/ ml, injectable solution
TRIMEBUTINA ANGENERICO 150 mg, 20 capsules
TRIMEDAT150 mg, 30 capsules

Japan:     

CEREKINON 20%, 1 g fine granules
CEREKINON 100 mg, tablets
SUPESLONE 100 mg, tablets
TRIMEBUTINE AMEL 100 mg, tablets
TRIMEBUTINE NICHI-IKO 100 mg, tablets
TRIMEBUTINE OHARA 20%, 1 g fine granules
TRIMEBUTINE OHARA 100 mg, tablets
TRIMEBUTINE SAWAI 100 mg, tablets
TRIMEBUTINE TOWA 100 mg, tablets
TRIMEBUTINE TSURUHARA 20%, 1 g fine granules
TRIMEBUTINE TSURUHARA 100 mg, tablets

Mexico:     

CINEPRAC 200 mg, 20-60 tablets
CINEPRAC 20 mg/ml, 40-100 ml oral suspensión
DEBRIDAT 200 mg, 40-60 tablets
DEBRIDAT 20 mg/ml, 40-100-200 ml oral suspensión
DOLBUTIN 200 mg, 30 tablets
ESPABION 200 mg, 40 tablets
ESPABION 20 mg/ml, 30 y 100 ml oral suspensión
KRISXON 100 mg,20-50 tablets
KRISXON 200 mg, 24-90 tablets
LIBERTRIM 10 ml/ml,injectable solution
LIBERTRIM 100 mg, 20-50 tablets
LIBERTRIM 200 mg, 24-90 tablets
LIBERTRIM LP 300 mg, 20-30 extended-release tablets
LIBERTRIM PEDIATRICO 20 mg/ml, 30 ml oral suspension
MUTTIFEN 100 mg, 12-60 tablets
MUTTIFEN 200 mg, 20100 tablets
TEMPOLIB 300 mg, 30 extended-release tablets

Pakistan:     

DEBRIDAT 24 mg/5 m, oral suspension
DEBRIDAT 100 mg, tablets
DEBRIDAT 200 mg, tablets
MEBUTINE 100 mg, tablets

Spain:     

POLIBUTIN 100 mg, 20 tablets
POLIBUTIN 24 mg/5 ml, 250 ml oral suspension

Turkey:     

DEBRIDAT 100 mg, 40 tablets
DEBRIDAT FORT 200 mg, 20-40-90 tablets
DEBRIDAT 24 mg/5 m, 250 oral suspension
GISMOTAL 100 mg, 40 tablets
GISMOTAL 200 mg, 20-40 tablets
GISMOTAL 24 mg/5 m, 250 oral suspension
PURIDAT FORT 200 mg, 20-40 tablets
TIREBRANT FORT 200 mg, 20-40 tablets
TRIBUDAT 100 mg, 40 tablets
TRIBUDAT 24 mg/5 m, 250 oral suspension
TRIBUDAT FORTE 200 mg, 20-40-90 tablets
TRIMEDIN 24 mg/5 m, 250 oral suspension
TRIMEDIN FORT 200 mg, 20-40 tablets

United Kingdom:     

N/A

U.S.A. and Puerto Rico:     

N/A

Page updated: December 11, 2010.