May 23 2022

Medicinal uses of common garlic (Allium Sativum))


Common garlic(<em>Allium Sativum</em>)

The popular Garlic is a plant belonging to the lily family, originary of Central Asia, from where its cultivation spreads worldwide. Garlic is one of the most important medicinal plants, especially appreciated in the Far East[1-3]. Also in USA is one of the most used medicinal plants[4].

Knowledge and use of garlic as a medicinal remedy is very old. Already in the Ebers Papyrus (1550 BC) were attributed antitumoral effects to this plant[5-6].

At the time of Dioscorides its use as therapeutic resource was widespread. According to the claims of this author, garlic can expel flatulences, causes disturbing belly, is desiccant of the stomach, generator of thirst and produces superficial ulcerations. Its therapeutic usefulness included elimination of intestinal parasites and ectoparasites such as lice and nits, snake bites and rabid dogs, provoking diuresis and sedation of cough, besides several other applications.

The first scientific observations of garlic start with Louis Pasteur, who was the first author to describe the antibacterial effect of garlic and onion[7]. Later have been happening experimental and clinical investigations that have left us at the gates of a lot of potential future applications based on scientific evidence.


Scientific names:

- Allium controversum
- Allium ophioscorodon
- Allium sativum subespecie ophioscorodon
- Allium sativum variedad ophioscorodon


Garlic exert its effects through more than 200 substances. This edible vegetable contains sulfur-containing compounds such as allicin, alliin and ajoene, volatile oils, enzymes (alliinase, peroxidase and miracinase), carbohydrates (sucrose and glucose), minerals (selenium), amino acids such as cysteine, glutamine, isoleucine and methionine, that help to protect cells from free radicals, bioflavonoids like quercetin and cyanidin, alistatin I and II and vitamins C, E and A to help protect people from oxidation and free radicals, as well as other vitamins like niacin, vitamins B1 and B2 and beta-carotene[1].

As just indicated, the components of garlic include enzymes as alliinase and amino acids containing sulphides, including alliin, an odorless and tasteless substance, devoid of therapeutic effects, derived from other(allicin) by effect of enzymes from the plant, when released by chew, crush or cut garlic[8]. Allicin can subsequently be transformed into other compounds with different biological properties, such as ajoene, vinilditine, diallyl disulfide or diallyl trisulfide.

Garlic has the particularity to have different properties depending on whether raw or cooked. If you cut or crushed a clove of garlic, alliin is released, which is converted by effects of alliinase in allicin. This transformation does not take place if previously garlic is cooked, releasing substances other as ajoene, which have different effects.

Allicin (diallyil thiosulfide) is the main biologically active component of garlic oil and is produced by the interaction between alliin and alliinase [9]. Allitridine is one of main active compounds of garlic [10]. The S-allyl-cysteine mercapto is an organosulfur derived from garlic, present in the alcoholic extract[11]. In addition to allicin and ajoene, already mentioned, can be detected other as allyl metyl thiosulphide, metyl allyl thiosulphide, alliin, deoxialliin, diallyl disulfide and diallyl trisulfide[12].

Allicin contains hydrogen sulfide as main compound, which, in theory, facilitates relaxation of vascular cells, reducing blood pressure, promoting circulation passage and transport of oxygen through the blood.

Although garlic contains over 20 sulfur compounds from a few amino acids, the function of each of them looks different from the other. For example, allicin, metyl allyl trisulphide and diallyl trisulphide have antibacterial, anti-thrombotic and anticancer activity respectively[13].

Diallyl trisulfide final compound is stable and proceed from degradation of allicin[14], that was first synthesized in China in 1981 and is used to treat infections causes by bacteria, fungi and other pathogens.

Immunomodulatory proteins present in garlic are ASA I and ASA II lectins. These substances, when are of nutritional origin, are very stable and with high immunogenic influence[15-16].

Ajoene (4,5,9-trithiadodeca-1,6,11-triene-9-oxide) is a derivative of garlic that has greater stability than allicin [6] .

The antibiotic effect is attributed to allicin, as the hypoglycemic effect, to which also contribute disulfide allyl propyl and S-allylcysteine sulfoxide compounds, while the anticancer effect would be related to diallyl mono sulphide. The inhibition of platelet aggregation would be due triallyl and diallyl sulfide compounds. Ajoene inactivates gastric lipase, closely related to digestion and absorption of fats. Tetra, hexa and hepta diallyl sulfides compounds are potentially antioxidants.

Medicinal properties of garlic are related to organosulfur compounds mainly alliin derivatives [5].

Properties and traditional applications     

Garlic has been traditionally used to treat a wide variety of ailments, including bacterial and fungal infections [17-18], intestinal worm infestations, wounds, diarrhea, rheumatism, diabetes mellitus, cardiovascular diseases (thrombosis, hypertension, hyperlipidemia), metabolic disorders and others. Today, this plant is included in traditional medicine in most cultures[19]. Garlic, available in various formulations for medicinal purposes has also been used to relieve symptoms caused by cancer and benign prostatic hypertrophy[20]. However, in all the applications listed, clinical evidence in support of these uses is very weak or is absent.

Popularly is also used or has been used in the past as mosquito repellent, anti-catarrhal, for hoarseness and as a sedative for cough. Topical application of garlic is used traditionally to treat skin warts.

Some organizations such as German Commission E, recommended garlic as an aid to dietary measures in patients with elevated blood lipid levels and as a preventive measure of vascular changes associated with aging. The British Herbal Pharmacopoeia attributed to garlic antibacterial properties, considering that is effective for respiratory infections and catarrhal conditions (The British Herbal Compendium). The indian Ayurveda Pharmacopoeia recommends the use of garlic as a brain tonic, appropriate in mental disorders and epilepsy.

In some parts of the Arab world stems inhalation of garlic is recommended to treat tuberculosis. In that cultural sphere is believed that eating garlic daily is good for preventing colic, diarrhea, abdominal pain, diabetes mellitus and inflammations. It is also recommended to boil peeled garlic cloves, accompanied by cow's milk, sen, laurel and pepper to treat colds, nephrosis and improve memory performance.

The ash of burnt garlic cloves would be used in that same culture to treat eye infections.

In general, garlic is one of the most widely used botanical therapeutic resources in the Arab world [21-22]. A study shows that over 10% of Jordanians with diabetes mellitus have taken garlic as a remedy for their illness[23]. In Palestine is recommended to treat cancer and prostate hypertrophy[24]. In the eastern area of Morocco, garlic is widely used as antihypertensive[25].

In traditional Bolivian culture is believed that eating garlic is good for atherosclerosis (three cloves of garlic and honey in a cup of milk), stroke, hypertension, gastric and respiratory problems, while soup of garlic would be recommended for circulatory problems and kidney.

Also is recommended a glass of water with 20 drops of tincture of garlic to treat bleeding, hypertension, palpitations and varicose veins.

In the Dominican Republic is considered appropriate to rub garlic on joints with rheumatic diseases. On the other side of the island, Haitians eat decoction of garlic bulbs, juices or infusions of the plant to treat dermatitis, bloating, itching, bronchitis, pneumonia and other bronchopulmonary diseases. Also eat the bulbs for treating high blood pressure or intestinal infestations.

In some areas of Mexico, it's recommended to take three cloves of garlic in a glass of milk every morning to prevent malaria and tuberculosis. Also is recommended as emmenagogue.

In Peru, garlic cloves are eaten to treat arrhythmias, arteriosclerosis, various other cardiovascular diseases (hypertension, thrombosis, stroke, etc.), diabetes mellitus, catarrhal states, malaria, menopause and smokers withdrawal syndrome . They also like to rub garlic on painful joints with rheumatism, skin warts, vitiligo, itchy areas, etc.

In rural areas of Guatemala, garlic is used as, often associated with conventional drugs[26].

In the Trinidad island, the decoction of garlic is used for hypertension, dyspepsia and stomach pain. It is customary in certain areas of the island rubbing the mother's abdomen with garlic to facilitate delivery.

The Yucatan people use garlic bulbs in milk or tomato juice to treat diabetes, rheumatism and malaria. It is keeping for 5 days in alcohol and is used in the form of drops for treating asthma, atherosclerosis and hypertension.

In India, the garlic is popularly used for the treatment of diabetes[27-28]. In Samahni Valley (Pakistan) is used the juice of garlic bulbs as anticancer medicine, birth control and antihypertension[29]. In the Sikh community living in the UK, garlic is one of the most used alternative medicines[30].

Also medicinal use in Europe has many followers. Thus, in Bulgaria is widely used for various diseases[31]. In the central regions of Italy, one study concludes that garlic is one of the most used plants, especially as anthelmintic[32-33].

In veterinary medicine, garlic is still used in British Columbia to treat parasitic fleas of pets (dogs, cats). It is also used to treat endoparasites and ear ailments in animals[34-35].

How it is applied

Garlic supports various forms of administration, such as ingestion of raw bulbs and leaves, tincture (20%, in 45% ethanol), as essential oil, syrup, solution and fresh juice.

Clinical Studies     

In general:

A systematic review and meta-analysis identifies six review on clinical efficacy of garlic. The evidence based on controlled clinical trials does not seem to be convincing from the viewpoint of the authors of the research. In the case of cholesterol, the effect size was considered small and probably with very little relevance. For hypertension, were available few studies and the effect was too small to be considered clinically significant. For other indications, no data were available to make any kind of clinical recommendation[36].

Cardiovascular/lipids effects

Some authors argue that garlic has therapeutic utility in patients with ischemic heart disease associated with diabetes[37]. A clinical trial of 12 weeks duration including 70 diabetic patients with elevated blood fats, showed a significant reduction in total cholesterol and LDL-cholesterol and elevation of HDL-cholesterol regarding starting values, which was not observed in the group of patients treated with placebo. According to the authors, the results suggest a beneficial effect of short-term garlic in diabetic patients with alteration of blood fats[38].

Using 12 months of a garlic preparation (Allicor) appeared to reduce the 10-year cardiovascular risk significantly in a clinical trial with 79 patients[39].

A systematic review of good methodological quality estimates that there is no scientific evidence beyond a reasonable doubt on the effectiveness of this vegetable in patients with peripheral artery disease[40].

A trial of six weeks duration in 30 patients with coronary disease showed a decrease in heart rate and overhead as well as improved exercise tolerance compared with baseline[41].

A clinical trial, double-blind, placebo-controlled and 12-week duration in 75 healthy volunteers, showed no significant difference between garlic and placebo with respect to pressure and arterial stiffness or blood lipid levels[42]. Other authors by contrast, observed a lipid-lowering effect with a garlic based product (Kwai]; they concluded that the degree of blood lipids decrease was related to prior level of blood lipids :the higher the starting level, the higher the fall of this[43].

The vast majority of published placebo controlled trials conclude that there is not support for a possible effect of garlic on lipid-lowering therapy. The scientific evidence about the effect of the plant on hypertension is notoriously inadequate in humans[44].

Other authors show their conviccción that garlic can normalize blood lipids, stimulate fibrinolytic activity, inhibit platelet aggregation, reduce roughness and arterial thickening, improving the structural alterations of the vessels associated with aging and atherosclerosis that lead to lower blood pressure[3].

One study concludes that continued treatment of tablets with high doses of garlic powder significantly reduced the increase in arteriosclerotic plaque between 5 and 18% during the 48 months of observation[45]. Other experts believe that there is some evidence suggesting that using certain formulations of garlic and/or onion is accompanied by an improvement of risk factors in normal subjects and patients with atherosclerosis[46]. Similarly, a review including numerous studies claims that garlic can normalize plasma lipids, stimulate fibrinolytic activity, inhibit platelet aggregation and reduce glucose and blood pressure, so the authors concluded that garlic has a remarkable potential in the prevention and control cardiovascular diseases[19].

A placebo-controlled clinical trial involving 60 patients with coronary disease, showed a significant reduction in total cholesterol and triglycerides, increasing HDL cholesterol and fibrinolytic activity[47].

A trial, including 24 healthy volunteers treated for six weeks with 900 mg of garlic powder, showed a decrease in postprandial triglycerides in analytical controls[48].

A review detects a decrease from 5 to 20% of cholesterol and triglycerides level in 7 out 8 trials, including more than 500 patients, using a daily dose of 0.6-0.9 grams garlic powder. The metabolic mechanisms of this reduction are unknown[49].

Effects on the common cold

A systematic review of the Cochrane Collaboration states that there is insufficient evidence of possible effects of garlic in preventing and treating the common cold, although several individual trials could support the opposite[50].

Cancer risk

There is not a credible evidence to support any effect of garlic on cancer and/or a reduction of cancer risk of stomach, breast, endometrial and lung. However, there is very limited evidence for a reduced risk of colon, prostate, esophagus, larynx, mouth, ovary and kidney cancers[51]. Overall, though the antitumor capacity of garlic has been evaluated in animal models, it has not been well established in humans[52].

An observational study seems to show an inverse association between consumption of garlic or other similar vegetables and the risk of several common cancers[53]. However, it is not possible to infer a cause-effect relationship from this kind of studies.

Arterial hypertension

Although some studies seem to show a positive effect on hypertension there are insufficient data about its efficacy in this disease[4].

A systematic review using MEDLINE, CINAHL and the Cochrane Central Register of Controlled Trials selected 10 papers that met the required criteria for methodological quality and concluded that the therapeutic use of garlic was associated with a reduction in systolic blood pressure in patients in whom this parameter was previously high, although no changes in diastolic blood pressure were recorded[54].

An observational case-control study showed that patients whose blood pressure was low was associated with a greater likelihood of consuming more garlic in their diet. The study recorded significantly lower values only for systolic pressure[55].


There is insufficient scientific evidence, based on clinical trials of good methodological quality, regarding this subject, so it can not be recommended the use of garlic for this purpose[56]. There is not general consensus on the use of garlic as antidiabetic agent, due not only to lack of consistent scientific evidence but also the controversial data from animal experiments[57].

Platelet function

A study in 18 healthy volunteers suggests that garlic, at dietary doses, does not alter the parameters related to the function of platelets and, therefore, does not increase the risk of bleeding in surgical interventions, although it has been shown experimentally inhibition of platelet aggregation by the plant[58-59].

Sickle cell anemia

A clinical trial in five patients with this type of anemia, undergoing treatment with a formulation of garlic, recorded a decline of Heinz bodies after 4 weeks of therapy, which, in the opinion of the authors, would show an antioxidant effect of red blood cells in these patients[60-61].

Antibacterial effects

Some studies indicate that garlic has a broad spectrum antibacterial activity[62].

The argued arguments for this purpose include:

1. Garlic juice was effective against the majority of intestinal pathogens responsible for gastroenteritis in humans and animals.
2. Garlic is effective even in the case of antibiotic-resistant strains.
3. Garlic combination with antibiotics resulting in total or partial synergy between the two components.
4. It has been repeatedly observed a complete lack of resistance of germs to garlic.
5. Garlic can even prevent the formation of toxins by microorganisms [7].

Hepatopulmonary syndrome

It has been published a case of a patient who suffered a severe hepatopulmonary syndrome in which had failed treatment with somatostatin and rejected liver transplant. By his own account, the patient ingested daily large amounts of garlic powder. After 18 months of following this regimen, experienced a partial improvement of symptoms[63].

A preliminary study of 6 months in 15 patients with HPS treated with encapsulated garlic powder appeared to improve arterial oxygenation and symptoms in six of the fifteen patients undergoing treatment[64].

Antiparasitic effect

A research conducted to evaluate the clinical usefulness of garlic in the treatment of ascariasis, to confirm the popular belief of its efficacy in this infestation, it has not been shown to have a conclusive effect[65].

Antifungal effect

After ingestion of 25 ml of garlic extract, a significant antifungal activity was detected in the serum at 30 and 60 minutes but not in the urine, so the trial authors consider that garlic would be of limited value in antifungal therapy[66].

Pharmacology and toxicology     

Garlic, in moderate doses, appears to be quite safe and usually does not cause adverse reactions, except for possible allergic reactions in some people that can be particularly severe, such as contact dermatitis and severe asthma attacks[8]. However it should be noted the possible acute or chronic toxicity from ingesting large amounts of this plant or its extracts[46].

The compounds contained in garlic can inhibit certain enzymes, so should be used only in limited quantities[67]

Some garlic derived substances containing thiol groups (sulfur-bearing) can cause acantholysis in vitro (Brenner et al. 1995) and, possibly, pemphigus in vivo.

More than five cloves of garlic a day induces flatulence and gastroesophageal heartburn (Castleman et al. 1996) in addition to antiplatelet effect. The maximum tolerated dose has been established in 25 ml of garlic extract. Higher levels can cause an intense feeling of esophageal or gastric burning and vomiting[66]. Even at lesser than maximum recommended doses, garlic can result in nausea, vomiting and diarrhea. The sulfide groups are local irritants and can cause digestive disorders and skin disorders if applied locally.

Garlic is contraindicated in patients with hyperthyroidism. The Commission E refers rare gastrointestinal symptoms with the medicinal use of garlic, allergic reactions, disorders in skin and halitosis. Local application of garlic or its essential oil may cause irritation at the site of application.

Raw garlic is estimated especially dangerous in children, very susceptible to the irritating effects of this plant.

Although there are no published cases of serious drug interactions, theoretically are possible by concurrent use of garlic with anticoagulants, anti-inflammatory and other drugs with an intense hepatic metabolism (antiretrovirals, quinolones, macrolides, calcium channel blockers, antidepressants, imidazole antifungals, theophylline, antipsychotics, etc.).

Some data suggest that S-allyl cysteine mercapto exert its protective action by inhibiting the activity of CYP2E1[11].

Experimental studies     

Please note:

The findings of experimental studies are not directly or indirectly applicable to humans. It is dangerous to infer from the findings of these studies alleged properties of this plant for the treatment of ailments in people.

Antiplatelet effect

Several studies have shown beneficial effect from garlic in the prevention of thromboembolic events[47][68-71].

Antibacterial and antifungal effects

Several studies show activity against Staphylococcus, Streptococcus Mutans and Streptococcus Pneumoniae,[4][72-79]. Garlic extract inhibits the development of Helicobacter pylori at minimum concentrations 2-5 mg/ml[80].

Other studies have also shown activity against bacteria and fungi as well as protozoa and other endoparasites including Giardia lamblia, Entamoeba histolytica and Trypanosoma spp[14][81-95].

The essential oil of garlic has shown marked growth inhibition in vitro of Trichophyton rubrum, Trichophyton erinacei and Trichophyton soudanense as well as a synergistic effect with ketoconazole[96]. Other species: such as Candida and Malassezia have also been sensitive to garlic derivatives[97]. A study seems to show that diallyl trisulfide has an antifungal activity in vitro against Cryptococcus species, that potentiates the effect of amphotericin B[98]. Other experimental studies also show antifungal effects against several microorganisms, including cytomegalovirus and leishmania[10][12][99-105].

Antitoxíc effects:

In laboratory animals, treatment with garlic, S-allyl cysteine mercapto, volatile oil or allicin counteracts the toxic effect of paracetamol, cadmium, lead, carbon tetrachloride, arsenic, galactosamine-lipopolysaccharide, mercury compounds and hypoxia[9][11][106-114].

Neurological effects

An experimental observation concludes that garlic can improve in laboratory animals physical performance and learning ability[115].

It was observed a significant improvement in memory function in the passive avoidance test. Elevated brain levels of 5-HT was associated with improved cognitive performance. These results seem to demonstrate that stimulation of memory is associated with an increase of this substance in rats[116].

Garlic extract showed a significant antidepressant effect, probably by inhibiting MAO A and B[117].

Anti-osteoporosis effect

A food supplement with garlic oil extract can counteract osteoporosis in ovariectomized rats, normalizing biochemical markers of disease[118]. The results of an study suggest that garlic may prevent bone loss due to ovarian failure, possibly increasing the transfer of calcium through intestine[119].

Hormonal/sexual effects

Aqueous extract of garlic has spermicide activity[120]. It has also been proven effective in animal models to treat thyroxine induced hyperglycemia[121].

In laboratory animals, consumption of raw garlic for a month reduced testosterone secretion and alter spermatogenesis in a dose-dependent manner[122].

The administration of aqueous extract of garlic for three months increased the weight of the seminal vesicles and epididymis in male animals and also sperm count[123].

Antioxidant effect

Some observations of Allium species show a strong antioxidant effect, due to its high concentration of flavonoids, carotenoids and chlorophyll derivatives[124-125]. According to the results of an in vitro study, garlic contain substances with remarkable free antiradical capacity[126].

It has been observed that old garlic extracts have free-radical activity, which is not the case of fresh extracts. The compounds S-allylcysteine and S-allyl cysteine mercapto are the most active agents[2].

Some studies indicate that the essential oil of garlic is an effective antioxidant in tissue damage produced by nicotine[127].

Antitumor effects

Allium sativum and some of its components can inhibit or delay the growth of various experimental tumors[2][128-140].Other studies indicate it may potentiate the effect of fludarabine and cytarabine[6] or could prevent the effect of certain carcinogens[141].

The authors of a study conclude that the compound S-allyl cysteine mercapto has significant antiproliferative action[142]. Previously, the same research group had shown that this substance inhibits cancer cell growth and causes apoptosis (cell death) in tissues of human colon cancer (Shirin et al, Cancer Res, 61:725-731, 2001). Diallyl sulfide significantly induces cell death[143-144] and activity of N-acetyltransferase[145]. Diallyl sulfide in vivo inhibits leukemic cell line WEHI-3[146].

Results of an observational study in animals indicate that ingestion of garlic inhibits the formation of intestinal cancer by N-Ethyl-N'-nitro-N-nitrosoguanidine[147]. Allicin inhibits cell growth and induces apoptosis in gastric epithelial cells[148]. The diallyl sulfur inhibits almost 3 out of 4 colorectal cancers induced by hydralazine dimethyl compound[149]. Diallyl sulfide inhibits N-acetyltransferase activity and gene expression in human colon cancer cells[150].

Cardiovascular effects

The dialysate of garlic has significant antiarrhythmic effect in both supraventricular and ventricular arrhythmias[151]. Studies on an experimental model suggest that garlic has beneficial effects on the strength of contraction and heart rate[152].

Allicin may influence atherosclerosis as an antioxidant and also through lipoproteins, modifying and inhibiting LDL cholesterol[153]. In any case, the influence of garlic and its derivatives on blood fats is higher the more higher the administered dose[154].

Both proteins and essential garlic oil show a significant lowering effect on blood fat[155]. The beneficial effect of garlic of blood fat is, at least in part, due to inhibition exerted on transaminases, alkaline phosphatase, HMG CoA reductase and other enzymes[156].

Allicin reduces the formation of atherosclerotic plaques in mice fed with a high cholesterol diet[157]. Garlic extract prevent the rise in blood fats caused by an atherogenic diet[158].

The addition of 2-3% of garlic powder to an atherogenic diet lowered total cholesterol concentrations in experimental rats. Paradoxically, were reduced more in animals receiving 2% of garlic than in those receiving 3%[159].

The alcoholic extract of garlic orally produced an antihypertensive effect in rats[160], while dialysate of garlic produced a fall of the minimum blood pressure and heart rate in a dose-dependent manner[161]. A single dose of garlic produces an antihypertensive effect in rats between 2 and 6 hours after administration, that could last up to more than 24 hours[162].

It has been shown in dogs a diuretic effect by intravenous administration of a purified fraction of garlic, which would reach the peak of action about three hours after administration[163]. Simultaneously a reduction in blood pressure is observed. High doses of garlic, above 15 mg/kg, cause bradycardia and ECG changes[164].

Antidiabetic effect

Some authors claim that the inclusion of garlic in the diet may help to lower glucose, cholesterol and triglycerides levels, based on experimental studies[165-167]. For other experts, garlic in the diet may reduce oxidative stress, but found no changes in cholesterol attributable to this plant[168].

In mice with experimental diabetes, garlic reduces polyphagia and polydipsia, but does not alter significantly hyperglycemia and hypoinsulinemia[169]. Other authors conclude that garlic would lower the postprandial hyperglycemic peak[170].

A study in rats with alloxan diabetes shows that S-allyl cysteine sulfoxide improves the disorder so nearly comparable to glibenclamide and insulin[171]. Administration of a dose of 200 mg/kg of S-allyl cysteine sulfoxide decreases blood concentration of fats, glucose and hepatic enzymatic activity[172].

Garlic administration decreases oxidative stress-induced hyperglycemia, thereby delaying the progression of lens opacification in diabetic rats[173].

Data from a study suggest that fresh garlic homogenate enhances nephropathy in mice with experimental streptozotocin diabetes[174].

Oral treatment of diabetic rats with Allium sativum and other plants, not only decreases the blood glucose level, but also reactivates antioxidant and other enzymes in the experimental model studied. According to these results, the effect would be comparable to glibenclamide. The authors conclude that garlic not only has a hypoglycemic effect but also decreases oxidative stress in experimental diabetes mellitus[175].

Another experimental study concludes that petroleum ether extract and raw garlic have some hypoglycemic effect, which is not observed in alcoholic extract[176].

Treatment of rats with alloxan induced diabetes with repeated administration of garlic can lead biochemical parameters to normal and may reduce liver and kidney damage induced by diabetes[177].

An experimental study on various medicinal plants showed that only garlic was able to reduce blood glucose significantly compared with the control group[178].

Compared with oral agents, antidiabetic effect of garlic was superior to glibenclamide[179].

ACE activity is higher in diabetic rats than in normals but animals treated with garlic show no enzyme elevation compared to controls. Study authors believe that garlic extract may have some value in preventing vascular complications of diabetes mellitus[180]..


A potential use of garlic derived from its action upon the production of cytokines, substances involved in inflammation, particularly inflammation of the small intestine[181].

Pretreatment with garlic suppresses chemically chromosomal aberrations induced in albino mice[182].

The garlic-derived S-allyl cysteine sulfoxide has shown a protective effect in the albino mouse against radiation induced by a cobalt-60 source, reducing the mortality caused by this agent. Moreover, the essential oil of garlic prevents fat elevation induced by radiocalcium[183].

immunostimulatory effect

Outcomes of a study supports a strong immunostimulatory effect by garlic, with an increase in cellular immunity parameters (percentage of phagocytic cells, granulocytes NBT positive and lysozyme level)[184]. Garlic orally can promote humoral response via cytokines[185] and can alter the phagocytic ability of blood cells[186].

The results of a study suggest that the two major proteins present in raw garlic, QR-2 and QR-1, contribute to the immunomodulatory activity of the plant, which would be very similar (if not identical) to the ASA I and II agglutinins[187].


Common garlic, Allium sativum, is one of the best-studied medicinal plants, if not the most. Despite the many indications of its potential therapeutic value, has not been conclusively established nor its clinical applicability neither its safety of use. For this reasons, MEDIZZINE believes that can not be recommended the use of garlic as a medicinal remedy. Possible toxic effects of the plant and its contraindication in children should be considered.


1: Ayaz E, Alpsoy HC. [Garlic (Allium sativum) and traditional medicine]. Turkiye Parazitol Derg. 2007;31(2):145-9. Abstract.
2: Thomson M, Ali M. Garlic [Allium sativum]: a review of its potential use as an anti-cancer agent. Curr Cancer Drug Targets. 2003 Feb;3(1):67-81.
3: García Gómez LJ, Sánchez-Muniz FJ. [Review: cardiovascular effect of garlic (Allium sativum)]. Arch Latinoam Nutr. 2000 Sep;50(3):219-29.
4: Edwards QT, Colquist S, Maradiegue A. What's cooking with garlic: is this complementary and alternative medicine for hypertension? J Am Acad Nurse Pract. 2005 Sep;17(9):381-5.
5: Iciek M, Kwiecien I, Wlodek L. Biological properties of garlic and garlic-derived organosulfur compounds. Environ Mol Mutagen. 2009 Apr;50(3):247-65.
6: Hassan HT. Ajoene (natural garlic compound): a new anti-leukaemia agent for AML therapy. Leuk Res. 2004 Jul;28(7):667-71.
7: Sivam GP. Protection against Helicobacter pylori and other bacterial infections by garlic. J Nutr. 2001 Mar;131(3s):1106S-8S.
8: Aviello G, Abenavoli L, Borrelli F, Capasso R, Izzo AA, Lembo F, Romano B, Capasso F. Garlic: empiricism or science? Nat Prod Commun. 2009 Dec;4(12):1785-96.
9: Vimal V, Devaki T. Hepatoprotective effect of allicin on tissue defense system in galactosamine/endotoxin challenged rats. J Ethnopharmacol. 2004 Jan;90(1):151-4.
10: Liu ZF, Fang F, Dong YS, Li G, Zhen H. Experimental study on the prevention and treatment of murine cytomegalovirus hepatitis by using allitridin. Antiviral Res. 2004 Feb;61(2):125-8.
11: Sumioka I, Matsura T, Yamada K. Therapeutic effect of S-allylmercaptocysteine on acetaminophen-induced liver injury in mice. Eur J Pharmacol. 2001 Dec 21;433(2-3):177-85.
12: Weber ND, Andersen DO, North JA, Murray BK, Lawson LD, Hughes BG. In vitro virucidal effects of Allium sativum (garlic) extract and compounds. Planta Med. 1992 Oct;58(5):417-23.
13: Ariga T, Seki T. Antithrombotic and anticancer effects of garlic-derived sulfur compounds: a review. Biofactors. 2006;26(2):93-103.
14: Lun ZR, Burri C, Menzinger M, Kaminsky R. Antiparasitic activity of diallyl trisulfide (Dasuansu) on human and animal pathogenic protozoa (Trypanosoma sp., Entamoeba histolytica and Giardia lamblia) in vitro. Ann Soc Belg Med Trop. 1994 Mar;74(1):51-9.
15: Clement F, Venkatesh YP. Dietary garlic (Allium sativum) lectins, ASA I and ASA II, are highly stable and immunogenic. Int Immunopharmacol. 2010 Jul 6.
16: Chandrashekar PM, Venkatesh YP. Identification of the protein components displaying immunomodulatory activity in aged garlic extract. J Ethnopharmacol. 2009 Jul 30;124(3):384-90.
17: Goncagul G, Ayaz E. Antimicrobial effect of garlic (Allium sativum). Recent Pat Antiinfect Drug Discov. 2010 Jan 1;5(1):91-3.
18: Thamburan S, Klaasen J, Mabusela WT, Cannon JF, Folk W, Johnson Q. Tulbaghia alliacea phytotherapy: a potential anti-infective remedy for candidiasis. Phytother Res. 2006 Oct;20(10):844-50.
19: Ernst E. Cardiovascular effects of garlic (Allium sativum): a review. Pharmatherapeutica. 1987;5(2):83-9.
20: Devrim E, Durak I. Is garlic a promising food for benign prostatic hyperplasia and prostate cancer? Mol Nutr Food Res. 2007 Nov;51(11):1319-23.
21: Aburjai T, Hudaib M, Tayyem R, Yousef M, Qishawi M. Ethnopharmacological survey of medicinal herbs in Jordan, the Ajloun Heights region. J Ethnopharmacol. 2007 Mar 21;110(2):294-304. Epub 2006 Oct 13.
22: Tahraoui A, El-Hilaly J, Israili ZH, Lyoussi B. Ethnopharmacological survey of plants used in the traditional treatment of hypertension and diabetes in south-eastern Morocco (Errachidia province). J Ethnopharmacol. 2007 Mar 1;110(1):105-17.
23: Otoom SA, Al-Safi SA, Kerem ZK, Alkofahi A. The use of medicinal herbs by diabetic Jordanian patients. J Herb Pharmacother. 2006;6(2):31-41.
24: Ali-Shtayeh MS, Yaniv Z, Mahajna J. Ethnobotanical survey in the Palestinian area: a classification of the healing potential of medicinal plants. J Ethnopharmacol. 2000 Nov;73(1-2):221-32.
25: Ziyyat A, Legssyer A, Mekhfi H, Dassouli A, Serhrouchni M, Benjelloun W. Phytotherapy of hypertension and diabetes in oriental Morocco. J Ethnopharmacol. 1997 Sep;58(1):45-54.
26: Booth S, Johns T, Lopez-Palacios CY. Factors influencing self-diagnosis and treatment of perceived helminthic infection in a rural Guatemalan community. Soc Sci Med. 1993 Aug;37(4):531-9.
27: Modak M, Dixit P, Londhe J, Ghaskadbi S, Paul A Devasagayam T. Indian herbs and herbal drugs used for the treatment of diabetes. J Clin Biochem Nutr. 2007 May;40(3):163-73.
28: Grover JK, Yadav S, Vats V. Medicinal plants of India with anti-diabetic potential. J Ethnopharmacol. 2002 Jun;81(1):81-100.
29: Ishtiaq M, Hanif W, Khan MA, Ashraf M, Butt AM. An ethnomedicinal survey and documentation of important medicinal folklore food phytonims of flora of Samahni valley, (Azad Kashmir) Pakistan. Pak J Biol Sci. 2007 Jul 1;10(13):2241-56.
30: Sandhu DS, Heinrich M. The use of health foods, spices and other botanicals in the Sikh community in London. Phytother Res. 2005 Jul;19(7):633-42.
31: Petkov V. Bulgarian traditional medicine: a source of ideas for phytopharmacological investigations. J Ethnopharmacol. 1986 Feb;15(2):121-32.
32: Guarrera PM. Traditional phytotherapy in Central Italy (Marche, Abruzzo, and Latium). Fitoterapia. 2005 Jan;76(1):1-25.
33: Guarrera PM. Traditional antihelmintic, antiparasitic and repellent uses of plants in Central Italy. J Ethnopharmacol. 1999 Dec 15;68(1-3):183-92.
34: Lans C, Turner N, Khan T. Medicinal plant treatments for fleas and ear problems of cats and dogs in British Columbia, Canada. Parasitol Res. 2008 Sep;103(4):889-98.
35: Lans C, Turner N, Khan T, Brauer G. Ethnoveterinary medicines used to treat endoparasites and stomach problems in pigs and pets in British Columbia, Canada. Vet Parasitol. 2007 Sep 30;148(3-4):325-40.
36: Pittler MH, Ernst E. Clinical effectiveness of garlic (Allium sativum). Mol Nutr Food Res. 2007 Nov;51(11):1382-5.
37: Dwivedi S, Aggarwal A. Indigenous drugs in ischemic heart disease in patients with diabetes. J Altern Complement Med. 2009 Nov;15(11):1215-21.
38: Ashraf R, Aamir K, Shaikh AR, Ahmed T. Effects of garlic on dyslipidemia in patients with type 2 diabetes mellitus. J Ayub Med Coll Abbottabad. 2005 Jul-Sep;17(3):60-4.
39: Sobenin IA, Prianishnikov VV, Kunnova LM, Radinovich EA, Orekhov AN. [Reduction of cardiovascular risk in primary prophylaxy of coronary heart disease]. Klin Med (Mosk). 2005;83(4):52-5. Abstract.
40: Pittler MH, Ernst E. Complementary therapies for peripheral arterial disease: systematic review. Atherosclerosis. 2005 Jul;181(1):1-7.
41: Verma SK, Rajeevan V, Jain P, Bordia A. Effect of garlic (Allium sativum) oil on exercise tolerance in patients with coronary artery disease. Indian J Physiol Pharmacol. 2005 Jan;49(1):115-8.
42: Turner B, Mølgaard C, Marckmann P. Effect of garlic (Allium sativum) powder tablets on serum lipids, blood pressure and arterial stiffness in normo-lipidaemic volunteers: a randomised, double-blind, placebo-controlled trial. Br J Nutr. 2004 Oct;92(4):701-6.
43: Chernyad'eva IF, Shil'nikova SV, Rogoza AN, Kukharchuk VV. Dynamics of interrelationships between the content of lipoprotein particles, fibrinogen, and leukocyte count in the plasma from patients with coronary heart disease treated with Kwai. Bull Exp Biol Med. 2003 May;135(5):436-9.
44: Brace LD. Cardiovascular benefits of garlic (Allium sativum L). J Cardiovasc Nurs. 2002 Jul;16(4):33-49.
45: Koscielny J, Klüssendorf D, Latza R, Schmitt R, Radtke H, Siegel G, Kiesewetter H. The antiatherosclerotic effect of Allium sativum. Atherosclerosis. 1999 May;144(1):237-49.
46: Kendler BS. Garlic (Allium sativum) and onion (Allium cepa): a review of their relationship to cardiovascular disease. Prev Med. 1987 Sep;16(5):670-85.
47: Bordia A, Verma SK, Srivastava KC. Effect of garlic (Allium sativum) on blood lipids, blood sugar, fibrinogen and fibrinolytic activity in patients with coronary artery disease. Prostaglandins Leukot Essent Fatty Acids. 1998 Apr;58(4):257-63.
48: Rotzsch W, Richter V, Rassoul F, Walper A. [Postprandial lipemia under treatment with Allium sativum. Controlled double-blind study of subjects with reduced HDL2-cholesterol]. Arzneimittelforschung. 1992 Oct;42(10):1223-7.
49: Brosche T, Platt D. [Garlic as phytogenic antilipemic agent. Recent studies with a standardized dry garlic powder substance]. Fortschr Med. 1990 Dec 20;108(36):703-6.
50: Lissiman E, Bhasale AL, Cohen M. Garlic for the common cold. Cochrane Database Syst Rev. 2009 Jul 8;(3):CD006206.
51: Kim JY, Kwon O. Garlic intake and cancer risk: an analysis using the Food and Drug Administration's evidence-based review system for the scientific evaluation of health claims. Am J Clin Nutr. 2009 Jan;89(1):257-64.
52: Mantle D, Lennard TW, Pickering AT. Therapeutic applications of medicinal plants in the treatment of breast cancer: a review of their pharmacology, efficacy and tolerability. Adverse Drug React Toxicol Rev. 2000 Aug;19(3):223-40.
53: Galeone C, Pelucchi C, Levi F, Negri E, Franceschi S, Talamini R, Giacosa A, La Vecchia C. Onion and garlic use and human cancer. Am J Clin Nutr. 2006 Nov;84(5):1027-32.
54: Reinhart KM, Coleman CI, Teevan C, Vachhani P, White CM. Effects of garlic on blood pressure in patients with and without systolic hypertension: a meta-analysis. Ann Pharmacother. 2008 Dec;42(12):1766-71.
55: Qidwai W, Qureshi R, Hasan SN, Azam SI. Effect of dietary garlic (Allium Sativum) on the blood pressure in humans--a pilot study. J Pak Med Assoc. 2000 Jun;50(6):204-7.
56: Cefalu WT, Ye J, Wang ZQ. Efficacy of dietary supplementation with botanicals on carbohydrate metabolism in humans. Endocr Metab Immune Disord Drug Targets. 2008 Jun;8(2):78-81.
57: Liu CT, Sheen LY, Lii CK. Does garlic have a role as an antidiabetic agent? Mol Nutr Food Res. 2007 Nov;51(11):1353-64.
58: Scharbert G, Kalb ML, Duris M, Marschalek C, Kozek-Langenecker SA. Garlic at dietary doses does not impair platelet function. Anesth Analg. 2007 Nov;105(5):1214-8, table of contents.
59: Beretz A, Cazenave JP. Old and new natural products as the source of modern antithrombotic drugs. Planta Med. 1991 Oct;57(7 Suppl):S68-72.
60: Takasu J, Uykimpang R, Sunga MA, Amagase H, Niihara Y. Aged garlic extract is a potential therapy for sickle-cell anemia. J Nutr. 2006 Mar;136(3 Suppl):803S-805S.
61: Takasu J, Uykimpang R, Sunga M, Amagase H, Niihara Y. Aged garlic extract therapy for sickle cell anemia patients. BMC Blood Disord. 2002 Jun 19;2(1):3.
62: Adetumbi MA, Lau BH. Allium sativum (garlic)--a natural antibiotic. Med Hypotheses. 1983 Nov;12(3):227-37.
63: Caldwell SH, Jeffers LJ, Narula OS, Lang EA, Reddy KR, Schiff ER. Ancient remedies revisited: does Allium sativum (garlic) palliate the hepatopulmonary syndrome? J Clin Gastroenterol. 1992 Oct;15(3):248-50.
64: Abrams GA, Fallon MB. Treatment of hepatopulmonary syndrome with Allium sativum L. (garlic): a pilot trial. J Clin Gastroenterol. 1998 Oct;27(3):232-5.
65: Campos R, Amato Neto V, Castanho RE, Moreira AA, Pinto PL. [Treatment of ascaridiasis with garlic (Allium sativum)]. Rev Hosp Clin Fac Med Sao Paulo. 1990 Sep-Oct;45(5):213-5.
66: Caporaso N, Smith SM, Eng RH. Antifungal activity in human urine and serum after ingestion of garlic (Allium sativum). Antimicrob Agents Chemother. 1983 May;23(5):700-2.
67: Augusti KT. Therapeutic values of onion (Allium cepa L.) and garlic (Allium sativum L.). Indian J Exp Biol. 1996 Jul;34(7):634-40.
68: Ali M. Mechanism by which garlic (Allium sativum) inhibits cyclooxygenase activity. Effect of raw versus boiled garlic extract on the synthesis of prostanoids. Prostaglandins Leukot Essent Fatty Acids. 1995 Dec;53(6):397-400.
69: Cavagnaro PF, Camargo A, Galmarini CR, Simon PW. Effect of cooking on garlic (Allium sativum L.) antiplatelet activity and thiosulfinates content. J Agric Food Chem. 2007 Feb 21;55(4):1280-8.
70: Bordia T, Mohammed N, Thomson M, Ali M. An evaluation of garlic and onion as antithrombotic agents. Prostaglandins Leukot Essent Fatty Acids. 1996 Mar;54(3):183-6.
71: Apitz-Castro R, Badimon JJ, Badimon L. Effect of ajoene, the major antiplatelet compound from garlic, on platelet thrombus formation. Thromb Res. 1992 Oct 15;68(2):145-55.
72: Tessema B, Mulu A, Kassu A, Yismaw G. An in vitro assessment of the antibacterial effect of garlic (Allium sativum) on bacterial isolates from wound infections. Ethiop Med J. 2006 Oct;44(4):385-9.
73: Gomaa NF, Hashish MH. The inhibitory effect of garlic (Allium sativum) on growth of some microorganisms. J Egypt Public Health Assoc. 2003;78(5-6):361-72.
74: González-Fandos E, García-López ML, Sierra ML, Otero A. Staphylococcal growth and enterotoxins (A-D) and thermonuclease synthesis in the presence of dehydrated garlic. J Appl Bacteriol. 1994 Nov;77(5):549-52.
75: Fani MM, Kohanteb J, Dayaghi M. Inhibitory activity of garlic (Allium sativum) extract on multidrug-resistant Streptococcus mutans. J Indian Soc Pedod Prev Dent. 2007 Oct-Dec;25(4):164-8.
76: Bakri IM, Douglas CW. Inhibitory effect of garlic extract on oral bacteria. Arch Oral Biol. 2005 Jul;50(7):645-51. Epub 2005 Feb 5. PubMed PMID: 15892950. 77: Groppo FC, Ramacciato JC, Simões RP, Flório FM, Sartoratto A. Antimicrobial activity of garlic, tea tree oil, and chlorhexidine against oral microorganisms. Int Dent J. 2002 Dec;52(6):433-7.
78: Eja ME, Asikong BE, Abriba C, Arikpo GE, Anwan EE, Enyi-Idoh KH. A comparative assessment of the antimicrobial effects of garlic (Allium sativum) and antibiotics on diarrheagenic organisms. Southeast Asian J Trop Med Public Health. 2007 Mar;38(2):343-8.
79: Dikasso D, Lemma H, Urga K, Debella A, Addis G, Tadele A, Yirsaw K. Investigation on the antibacterial properties of garlic (Allium sativum) on pneumonia causing bacteria. Ethiop Med J. 2002 Jul;40(3):241-9.
80: Cellini L, Di Campli E, Masulli M, Di Bartolomeo S, Allocati N. Inhibition of Helicobacter pylori by garlic extract (Allium sativum). FEMS Immunol Med Microbiol. 1996 Apr;13(4):273-7.
81: Elnima EI, Ahmed SA, Mekkawi AG, Mossa JS. The antimicrobial activity of garlic and onion extracts. Pharmazie. 1983 Nov;38(11):747-8.
82: Dankert J, Tromp TF, de Vries H, Klasen HJ. Antimicrobial activity of crude juices of Allium ascalonicum, Allium cepa and Allium sativum. Zentralbl Bakteriol Orig A. 1979 Oct;245(1-2):229-39.
83: Chowdhury AK, Ahsan M, Islam SN, Ahmed ZU. Efficacy of aqueous extract of garlic & allicin in experimental shigellosis in rabbits. Indian J Med Res. 1991 Jan;93:33-6.
84: Delaha EC, Garagusi VF. Inhibition of mycobacteria by garlic extract (Allium sativum). Antimicrob Agents Chemother. 1985 Apr;27(4):485-6.
85: Kumar M, Berwal JS. Sensitivity of food pathogens to garlic (Allium sativum). J Appl Microbiol. 1998 Feb;84(2):213-5.
86: Vijaya K, Ananthan S. Microbiological screening of Indian medicinal plants with special reference to enteropathogens. J Altern Complement Med. 1997 Spring;3(1):13-20.
87: Louria DB, Lavenhar M, Kaminski T, Eng RH. Garlic (Allium sativum) in the treatment of experimental cryptococcosis. J Med Vet Mycol. 1989;27(4):253-6.
88: Polat ZA, Vural A, Ozan F, Tepe B, Ozcelik S, Cetin A. In vitro evaluation of the amoebicidal activity of garlic (Allium sativum) extract on Acanthamoeba castellanii and its cytotoxic potential on corneal cells. J Ocul Pharmacol Ther. 2008 Feb;24(1):8-14.
89: Mirelman D, Monheit D, Varon S. Inhibition of growth of Entamoeba histolytica by allicin, the active principle of garlic extract (Allium sativum). J Infect Dis. 1987 Jul;156(1):243-4.
90: Thomaz L, Apitz-Castro R, Marques AF, Travassos LR, Taborda CP. Experimental paracoccidioidomycosis: alternative therapy with ajoene, compound from Allium sativum, associated with sulfamethoxazole/trimethoprim. Med Mycol. 2008 Mar;46(2):113-8.
91: Perez HA, De la Rosa M, Apitz R. In vivo activity of ajoene against rodent malaria. Antimicrob Agents Chemother. 1994 Feb;38(2):337-9.
92: Nok AJ, Williams S, Onyenekwe PC. Allium sativum-induced death of African trypanosomes. Parasitol Res. 1996;82(7):634-7.
93: Harris JC, Plummer S, Turner MP, Lloyd D. The microaerophilic flagellate Giardia intestinalis: Allium sativum (garlic) is an effective antigiardial. Microbiology. 2000 Dec;146 Pt 12:3119-27.
94: Soffar SA, Mokhtar GM. Evaluation of the antiparasitic effect of aqueous garlic (Allium sativum) extract in hymenolepiasis nana and giardiasis. J Egypt Soc Parasitol. 1991 Aug;21(2):497-502.
95: Raj RK. Screening of indigenous plants for anthelmintic action against human Ascaris lumbricoides: Part--II. Indian J Physiol Pharmacol. 1975 Jan-Mar;19(1)
96: Pyun MS, Shin S. Antifungal effects of the volatile oils from Allium plants against Trichophyton species and synergism of the oils with ketoconazole. Phytomedicine. 2006 Jun;13(6):394-400.
97: Shams-Ghahfarokhi M, Shokoohamiri MR, Amirrajab N, Moghadasi B, Ghajari A, Zeini F, Sadeghi G, Razzaghi-Abyaneh M. In vitro antifungal activities of Allium cepa, Allium sativum and ketoconazole against some pathogenic yeasts and dermatophytes. Fitoterapia. 2006 Jun;77(4):321-3.
98: Shen J, Davis LE, Wallace JM, Cai Y, Lawson LD. Enhanced diallyl trisulfide has in vitro synergy with amphotericin B against Cryptococcus neoformans. Planta Med. 1996 Oct;62(5):415-8.
99: Venugopal PV, Venugopal TV. Antidermatophytic activity of garlic (Allium sativum) in vitro. Int J Dermatol. 1995 Apr;34(4):278-9.
100: Pai ST, Platt MW. Antifungal effects of Allium sativum (garlic) extract against the Aspergillus species involved in otomycosis. Lett Appl Microbiol. 1995 Jan;20(1):14-8.
101: Davis LE, Shen J, Royer RE. In vitro synergism of concentrated Allium sativum extract and amphotericin B against Cryptococcus neoformans. Planta Med. 1994 Dec;60(6):546-9.
102: Davis SR, Perrie R, Apitz-Castro R. The in vitro susceptibility of Scedosporium prolificans to ajoene, allitridium and a raw extract of garlic (Allium sativum). J Antimicrob Chemother. 2003 Mar;51(3):593-7.
103: Ghannoum MA. Inhibition of Candida adhesion to buccal epithelial cells by an aqueous extract of Allium sativum (garlic). J Appl Bacteriol. 1990 Feb;68(2):163-9.
104: Zhen H, Fang F, Ye DY, Shu SN, Zhou YF, Dong YS, Nie XC, Li G. Experimental study on the action of allitridin against human cytomegalovirus in vitro: Inhibitory effects on immediate-early genes. Antiviral Res. 2006 Oct;72(1):68-74. Epub 2006 Apr 27.
105: Ghazanfari T, Hassan ZM, Khamesipour A. Enhancement of peritoneal macrophage phagocytic activity against Leishmania major by garlic (Allium sativum) treatment. J Ethnopharmacol. 2006 Feb 20;103(3):333-7.
106: El-Beshbishy HA. Aqueous garlic extract attenuates hepatitis and oxidative stress induced by galactosamine/lipoploysaccharide in rats. Phytother Res. 2008 Oct;22(10):1372-9.
107: Suru SM. Onion and garlic extracts lessen cadmium-induced nephrotoxicity in rats. Biometals. 2008 Dec;21(6):623-33.
108: Massadeh AM, Al-Safi SA, Momani IF, Alomary AA, Jaradat QM, AlKofahi AS. Garlic (Allium sativum L.) as a potential antidote for cadmium and lead intoxication: cadmium and lead distribution and analysis in different mice organs. Biol Trace Elem Res. 2007 Winter;120(1-3):227-34.
109: Cha CW. A study on the effect of garlic to the heavy metal poisoning of rat. J Korean Med Sci. 1987 Dec;2(4):213-24.
110: Hosseinzadeh H, Sadati N. The protective effect of Allium sativum L. clove aqueous and methanolic extracts against hypoxia-induced lethality in mice. Phytother Res. 2003 Mar;17(3):279-81.
111: Senapati SK, Dey S, Dwivedi SK, Swarup D. Effect of garlic (Allium sativum L.) extract on tissue lead level in rats. J Ethnopharmacol. 2001 Aug;76(3):229-32.
112: Patrick-Iwuanyanwu KC, Wegwu MO, Ayalogu EO. Prevention of CCl4-induced liver damage by ginger, garlic and vitamin E. Pak J Biol Sci. 2007 Feb 15;10(4):617-21.
113: Chowdhury R, Dutta A, Chaudhuri SR, Sharma N, Giri AK, Chaudhuri K. In vitro and in vivo reduction of sodium arsenite induced toxicity by aqueous garlic extract. Food Chem Toxicol. 2008 Feb;46(2):740-51.
114: Hikino H, Tohkin M, Kiso Y, Namiki T, Nishimura S, Takeyama K. Antihepatotoxic Actions of Allium sativum Bulbs1. Planta Med. 1986 Jun;52(3):163-8.
115: Sookvanichsilp N, Tiangda C, Yuennan P. Effects of raw garlic on physical performance and learning behaviour in rats. Phytother Res. 2002 Dec;16(8):732-6.
116: Haider S, Naz N, Khaliq S, Perveen T, Haleem DJ. Repeated administration of fresh garlic increases memory retention in rats. J Med Food. 2008 Dec;11(4):675-9.
117: Dhingra D, Kumar V. Evidences for the involvement of monoaminergic and GABAergic systems in antidepressant-like activity of garlic extract in mice. Indian J Pharmacol. 2008 Aug;40(4):175-9.
118: Mukherjee M, Das AS, Mitra S, Mitra C. Prevention of bone loss by oil extract of garlic (Allium sativum Linn.) in an ovariectomized rat model of osteoporosis. Phytother Res. 2004 May;18(5):389-94.
119: Mukherjee M, Das AS, Das D, Mukherjee S, Mitra S, Mitra C. Role of oil extract of garlic (Allium sativum Linn.) on intestinal transference of calcium and its possible correlation with preservation of skeletal health in an ovariectomized rat model of osteoporosis. Phytother Res. 2006 May;20(5):408-15.
120: Chakrabarti K, Pal S, Bhattacharyya AK. Sperm immobilization activity of Allium sativum L. and other plant extracts. Asian J Androl. 2003 Jun;5(2):131-5. Erratum in: Asian J Androl. 2003 Sep;5(3):230.
121: Tahiliani P, Kar A. Mitigation of thyroxine-induced hyperglycaemia by two plant extracts. Phytother Res. 2003 Mar;17(3):294-6.
122: Hammami I, Nahdi A, Mauduit C, Benahmed M, Amri M, Ben Amar A, Zekri S, El May A, El May MV. The inhibitory effects on adult male reproductive functions of crude garlic (Allium sativum) feeding. Asian J Androl. 2008 Jul;10(4):593-601.
123: al-Bekairi AM, Shah AH, Qureshi S. Effect of Allium sativum on epididymal spermatozoa, estradiol-treated mice and general toxicity. J Ethnopharmacol. 1990 May;29(2):117-25.
124: Stajner D, Milic N, Canadanovic-Brunet J, Kapor A, Stajner M, Popovic BM. Exploring Allium species as a source of potential medicinal agents. Phytother Res. 2006 Jul;20(7):581-4.
125: Prasad S, Kalra N, Srivastava S, Shukla Y. Regulation of oxidative stress-mediated apoptosis by diallyl sulfide in DMBA-exposed Swiss mice. Hum Exp Toxicol. 2008 Jan;27(1):55-63.
126: Török B, Belágyi J, Rietz B, Jacob R. Effectiveness of garlic on the radical activity in radical generating systems. Arzneimittelforschung. 1994 May;44(5):608-11.
127: Helen A, Rajasree CR, Krishnakumar K, Augusti KT, Vijayammal PL. Antioxidant role of oils isolated from garlic (Allium sativum Linn) and onion (Allium cepa Linn) on nicotine-induced lipid peroxidation. Vet Hum Toxicol. 1999 Oct;41(5):316-9.
128: Li Q, Li S, Yang G. [Study of anti-tumor action and influence on immune function of Allium stativum]. Zhong Yao Cai. 1998 May;21(5):240-3. Abstract.
129: Oommen S, Anto RJ, Srinivas G, Karunagaran D. Allicin (from garlic) induces caspase-mediated apoptosis in cancer cells. Eur J Pharmacol. 2004 Feb 6;485(1-3):97-103.
130: Bhattacharyya M, Girish GV, Karmohapatra SK, Samad SA, Sinha AK. Systemic production of IFN-alpha by garlic (Allium sativum) in humans. J Interferon Cytokine Res. 2007 May;27(5):377-82.
131: Lamm DL, Riggs DR. The potential application of Allium sativum (garlic) for the treatment of bladder cancer. Urol Clin North Am. 2000 Feb;27(1):157-62, xi.
132: Krest I, Keusgen M. Stabilization and pharmaceutical use of alliinase. Pharmazie. 1999 Apr;54(4):289-93.
133: Kwon KB, Yoo SJ, Ryu DG, Yang JY, Rho HW, Kim JS, Park JW, Kim HR, Park BH. Induction of apoptosis by diallyl disulfide through activation of caspase-3 in human leukemia HL-60 cells. Biochem Pharmacol. 2002 Jan 1;63(1):41-7.
134: Balasenthil S, Ramachandran CR, Nagini S. Prevention of 4-nitroquinoline 1-oxide-induced rat tongue carcinogenesis by garlic. Fitoterapia. 2001 Jun;72(5):524-31.
135: Shirin H, Pinto JT, Kawabata Y, Soh JW, Delohery T, Moss SF, Murty V, Rivlin RS, Holt PR, Weinstein IB. Antiproliferative effects of S-allylmercaptocysteine on colon cancer cells when tested alone or in combination with sulindac sulfide. Cancer Res. 2001 Jan 15;61(2):725-31.
136: Samaranayake MD, Wickramasinghe SM, Angunawela P, Jayasekera S, Iwai S, Fukushima S. Inhibition of chemically induced liver carcinogenesis in Wistar rats by garlic (Allium sativum). Phytother Res. 2000 Nov;14(7):564-7.
137: Balasenthil S, Arivazhagan S, Ramachandran CR, Nagini S. Effects of garlic on 7,12-Dimethylbenz[a]anthracene-induced hamster buccal pouch carcinogenesis. Cancer Detect Prev. 1999;23(6):534-8.
138: Singh A, Shukla Y. Antitumor activity of diallyl sulfide in two-stage mouse skin model of carcinogenesis. Biomed Environ Sci. 1998 Sep;11(3):258-63.
139: Riggs DR, DeHaven JI, Lamm DL. Allium sativum (garlic) treatment for murine transitional cell carcinoma. Cancer. 1997 May 15;79(10):1987-94.
140: Rao AR, Sadhana AS, Goel HC. Inhibition of skin tumors in DMBA-induced complete carcinogenesis system in mice by garlic (Allium sativum). Indian J Exp Biol. 1990 May;28(5):405-8.
141: Wargovich MJ, Woods C, Eng VW, Stephens LC, Gray K. Chemoprevention of N-nitrosomethylbenzylamine-induced esophageal cancer in rats by the naturally occurring thioether, diallyl sulfide. Cancer Res. 1988 Dec 1;48(23):6872-5.
142: Xiao D, Pinto JT, Soh JW, Deguchi A, Gundersen GG, Palazzo AF, Yoon JT, Shirin H, Weinstein IB. Induction of apoptosis by the garlic-derived compound S-allylmercaptocysteine (SAMC) is associated with microtubule depolymerization and c-Jun NH(2)-terminal kinase 1 activation. Cancer Res. 2003 Oct 15;63(20):6825-37.
143: Lu HF, Sue CC, Yu CS, Chen SC, Chen GW, Chung JG. Diallyl disulfide (DADS) induced apoptosis undergo caspase-3 activity in human bladder cancer T24 cells. Food Chem Toxicol. 2004 Oct;42(10):1543-52.
144: Wu XJ, Kassie F, Mersch-Sundermann V. The role of reactive oxygen species (ROS) production on diallyl disulfide (DADS) induced apoptosis and cell cycle arrest in human A549 lung carcinoma cells. Mutat Res. 2005 Nov 11;579(1-2):115-24.
145: Yu FS, Yu CS, Lin JP, Chen SC, Lai WW, Chung JG. Diallyl disulfide inhibits N-acetyltransferase activity and gene expression in human esophagus epidermoid carcinoma CE 81T/VGH cells. Food Chem Toxicol. 2005 Jul;43(7):1029-36.
146: Yang JS, Kok LF, Lin YH, Kuo TC, Yang JL, Lin CC, Chen GW, Huang WW, Ho HC, Chung JG. Diallyl disulfide inhibits WEHI-3 leukemia cells in vivo. Anticancer Res. 2006 Jan-Feb;26(1A):219-25.
147: Shimpo K, Chihara T, Kaneko T, Shinzato M, Beppu H, Hoshino M, Ida C, Shamoto M, Kuzuya H. Inhibitory Effects of Heated Garlic on N-Ethyl-N'-nitro-N-nitrosoguanidine-induced Carcinogenesis in the Duodenum and Jejunum of C57BL/6 Mice. Asian Pac J Cancer Prev. 2002;3(4):339-344.
148: Park SY, Cho SJ, Kwon HC, Lee KR, Rhee DK, Pyo S. Caspase-independent cell death by allicin in human epithelial carcinoma cells: involvement of PKA. Cancer Lett. 2005 Jun 16;224(1):123-32. Epub 2004 Nov 14.
149: Wargovich MJ. Diallyl sulfide, a flavor component of garlic (Allium sativum), inhibits dimethylhydrazine-induced colon cancer. Carcinogenesis. 1987 Mar;8(3):487-9.
150: Chung JG, Lu HF, Yeh CC, Cheng KC, Lin SS, Lee JH. Inhibition of N-acetyltransferase activity and gene expression in human colon cancer cell lines by diallyl sulfide. Food Chem Toxicol. 2004 Feb;42(2):195-202.
151: Martín N, Bardisa L, Pantoja C, Vargas M, Quezada P, Valenzuela J. Anti-arrhythmic profile of a garlic dialysate assayed in dogs and isolated atrial preparations. J Ethnopharmacol. 1994 Jun;43(1):1-8.
152: Yadav RK, Verma NS. Effects of garlic (Allium sativum) extract on the heart rate, rhythm and force of contraction in frog: a dose-dependent study. Indian J Exp Biol. 2004 Jun;42(6):628-31.
153: Gonen A, Harats D, Rabinkov A, Miron T, Mirelman D, Wilchek M, Weiner L, Ulman E, Levkovitz H, Ben-Shushan D, Shaish A. The antiatherogenic effect of allicin: possible mode of action. Pathobiology. 2005;72(6):325-34.
154: Gorinstein S, Leontowicz M, Leontowicz H, Jastrzebski Z, Drzewiecki J, Namiesnik J, Zachwieja Z, Barton H, Tashma Z, Katrich E, Trakhtenberg S. Dose-dependent influence of commercial garlic (Allium sativum) on rats fed cholesterol-containing diet. J Agric Food Chem. 2006 May 31;54(11):4022-7.
155: Mathew BC, Daniel RS, Augusti KT. Hypolipidemic effect of garlic protein substituted for casein in diet of rats compared to those of garlic oil. Indian J Exp Biol. 1996 Apr;34(4):337-40.
156: Sheela CG, Augusti KT. Effects of S-allyl cysteine sulfoxide isolated from Allium sativum Linn and gugulipid on some enzymes and fecal excretions of bile acids and sterols in cholesterol fed rats. Indian J Exp Biol. 1995 Oct;33(10):749-51.
157: Abramovitz D, Gavri S, Harats D, Levkovitz H, Mirelman D, Miron T, Eilat-Adar S, Rabinkov A, Wilchek M, Eldar M, Vered Z. Allicin-induced decrease in formation of fatty streaks (atherosclerosis) in mice fed a cholesterol-rich diet. Coron Artery Dis. 1999 Oct;10(7):515-9.
158: Lata S, Saxena KK, Bhasin V, Saxena RS, Kumar A, Srivastava VK. Beneficial effects of Allium sativum, Allium cepa and Commiphora mukul on experimental hyperlipidemia and atherosclerosis--a comparative evaluation. J Postgrad Med. 1991 Jul;37(3):132-5.
159: Kamanna VS, Chandrasekhara N. Effect of garlic (Allium sativum linn) on serum lipoproteins and lipoprotein cholesterol levels in albino rats rendered hypercholesteremic by feeding cholesterol. Lipids. 1982 Jul;17(7):483-8.
160: Ribeiro Rde A, Fiuza de Melo MM, De Barros F, Gomes C, Trolin G. Acute antihypertensive effect in conscious rats produced by some medicinal plants used in the state of São Paulo. J Ethnopharmacol. 1986 Mar;15(3):261-9.
161: Martín N, Bardisa L, Pantoja C, Román R, Vargas M. Experimental cardiovascular depressant effects of garlic (Allium sativum) dialysate. J Ethnopharmacol. 1992 Sep;37(2):145-9.
162: Al-Qattan KK, Alnaqeeb MA, Ali M. The antihypertensive effect of garlic (Allium sativum) in the rat two-kidney--one-clip Goldblatt model. J Ethnopharmacol. 1999 Aug;66(2):217-22.
163: Pantoja CV, Martín NT, Norris BC, Contreras CM. Purification and bioassays of a diuretic and natriuretic fraction from garlic (Allium sativum). J Ethnopharmacol. 2000 Apr;70(1):35-40.
164: Pantoja CV, Chiang LC, Norris BC, Concha JB. Diuretic, natriuretic and hypotensive effects produced by Allium sativum (garlic) in anaesthetized dogs. J Ethnopharmacol. 1991 Mar;31(3):325-31.
165: Thomson M, Al-Qattan KK, Bordia T, Ali M. Including garlic in the diet may help lower blood glucose, cholesterol, and triglycerides. J Nutr. 2006 Mar;136(3 Suppl):800S-802S.
166: Augusti KT, Arathy SL, Asha R, Ramakrishanan J, Zaira J, Lekha V, Smitha S, Vijayasree VM. A comparative study on the beneficial effects of garlic (Allium sativum Linn), amla (Emblica Officinalis Gaertn)and onion (Allium cepa Linn) on the hyperlipidemia induced by butter fat and beef fat in rats. Indian J Exp Biol. 2001 Aug;39(8):760-6.
167: Augusti KT, Narayanan A, Pillai LS, Ebrahim RS, Sivadasan R, Sindhu KR, Subha I, Abdeen S, Nair SS. Beneficial effects of garlic (Allium sativum Linn) on rats fed with diets containing cholesterol and either of the oil seeds, coconuts or groundnuts. Indian J Exp Biol. 2001 Jul;39(7):660-7.
168: Choi EY, Cho YO. Allium vegetable diet can reduce the exercise-induced oxidative stress but does not alter plasma cholesterol profile in rats. Ann Nutr Metab. 2006;50(2):132-8.
169: Swanston-Flatt SK, Day C, Bailey CJ, Flatt PR. Traditional plant treatments for diabetes. Studies in normal and streptozotocin diabetic mice. Diabetologia. 1990 Aug;33(8):462-4.
170: Roman-Ramos R, Flores-Saenz JL, Alarcon-Aguilar FJ. Anti-hyperglycemic effect of some edible plants. J Ethnopharmacol. 1995 Aug 11;48(1):25-32.
171: Augusti KT, Sheela CG. Antiperoxide effect of S-allyl cysteine sulfoxide, an insulin secretagogue, in diabetic rats. Experientia. 1996 Feb 15;52(2):115-20.
172: Sheela CG, Augusti KT. Antidiabetic effects of S-allyl cysteine sulphoxide isolated from garlic Allium sativum Linn. Indian J Exp Biol. 1992 Jun;30(6):523-6.
173: Raju TN, Kanth VR, Lavanya K. Effect of methanolic extract of Allium sativum (AS) in delaying cataract in STZ-induced diabetic rats. J Ocul Biol Dis Infor. 2008 Mar;1(1):46-54.
174: Mariee AD, Abd-Allah GM, El-Yamany MF. Renal oxidative stress and nitric oxide production in streptozotocin-induced diabetic nephropathy in rats: the possible modulatory effects of garlic (Allium sativum L.). Biotechnol Appl Biochem. 2009 Mar;52(Pt 3):227-32.
175: Chandra A, Mahdi AA, Singh RK, Mahdi F, Chander R. Effect of Indian herbal hypoglycemic agents on antioxidant capacity and trace elements content in diabetic rats. J Med Food. 2008 Sep;11(3):506-12.
176: Nyyer MA, Siddiqui AA, Athar HS. Hypoglycemic effect of Allium sativum on oral glucose tolerance test in rabbits. Pak J Pharm Sci. 1989 Jan;2(1):49-53.
177: El-Demerdash FM, Yousef MI, El-Naga NI. Biochemical study on the hypoglycemic effects of onion and garlic in alloxan-induced diabetic rats. Food Chem Toxicol. 2005 Jan;43(1):57-63.
178: Jelodar GA, Maleki M, Motadayen MH, Sirus S. Effect of fenugreek, onion and garlic on blood glucose and histopathology of pancreas of alloxan-induced diabetic rats. Indian J Med Sci. 2005 Feb;59(2):64-9.
179: Eidi A, Eidi M, Esmaeili E. Antidiabetic effect of garlic (Allium sativum L.) in normal and streptozotocin-induced diabetic rats. Phytomedicine. 2006 Nov;13(9-10):624-9.
180: Hosseini M, Shafiee SM, Baluchnejadmojarad T. Garlic extract reduces serum angiotensin converting enzyme (ACE) activity in nondiabetic and streptozotocin-diabetic rats. Pathophysiology. 2007 Oct;14(2):109-12.
181: Hodge G, Hodge S, Han P. Allium sativum (garlic) suppresses leukocyte inflammatory cytokine production in vitro: potential therapeutic use in the treatment of inflammatory bowel disease. Cytometry. 2002 Aug 1;48(4):209-15.
182: Shukla Y, Taneja P. Antimutagenic effects of garlic extract on chromosomal aberrations. Cancer Lett. 2002 Feb 8;176(1):31-6.
183: Jaiswal SK, Bordia A. Radio-protective effect of garlic Allium sativum Linn. in albino rats. Indian J Med Sci. 1996 Jul;50(7):231-3. Erratum in: Indian J Med Sci 1996 Nov;50(11):334.
184: Truchlinski J, Krauze M, Cendrowska-Pinkosz M, Modzelewska-Banachiewicz B. Influence of garlic, synthetic 1,2,4-triasole derivative and herbal preparation echinovit C on selected indices of turkey-hens non-specific immunity. Pol J Vet Sci. 2006;9(1):51-5.
185: Zamani A, Vahidinia A, Ghannad MS. The effect of garlic consumption on Th1/Th2 cytokines in phytohemagglutinin (PHA) activated rat spleen lymphocytes. Phytother Res. 2009 Apr;23(4):579-81.
186: Dorhoi A, Dobrean V, Zahan M, Virag P. Modulatory effects of several herbal extracts on avian peripheral blood cell immune responses. Phytother Res. 2006 May;20(5):352-8.
187: Clement F, Pramod SN, Venkatesh YP. Identity of the immunomodulatory proteins from garlic (Allium sativum) with the major garlic lectins or agglutinins. Int Immunopharmacol. 2010 Mar;10(3):316-24.

Date of page update: January 7, 2011.


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