May 22 2022

Classification of the active ingredient ibuprofen

Risk level in pregnancy: This medicine is classified as Category category B for the 1st and 2nd quarter and category D for the 3rd..

Some experts recommend not to use ibuprofen during the entire pregnancy. Others, however, emphasize not to use the drug during the last quarter due to the risk of premature closure of the ductus arteriosus or difficult labor as a result of prostaglandin synthetase inhibition.

Animal studies have shown no risk to the fetus and term products, with the exception of decreased fertility.

Clinical studies in pregnant women have not detected adverse effects during the first quarter. By contrast, during the last quarter have been isolated reports of early closure of the ductus, kidney failure, bleeding, oligohydramnios and ileal perforation in relation to taking antiinflammatory drugs, including ibuprofen.

Update 18.07.2009

Meaning of category C

Animal reproduction studies have shown an adverse effect on the fetus and there are no adequate and well-controlled studies in humans, but potential benefits may warrant use of the drug in pregnant women despite potential risks.