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Adverse reactions to Allopurinol

  • 1. Abdominal pain

    • Rare.

  • 2. Acute interstitial nephritis

    • Very rare.. Case report: CMAJ. 1986 Dec 1;135(11):1278-81. Nephrologie. 1986;7(2):47-9. Am J Nephrol. 1981;1(2):105-9.

  • 3. Acute renal failure

    • Very rare.. Case report: Kaohsiung J Med Sci. 2005 May;21(5):228-32. CMAJ. 1986 Dec 1;135(11):1278-81. Aust N Z J Med. 1977 Oct;7(5):518-22.

  • 4. Ageusia

    • Very rare.

  • 5. Agranulocytosis

    • Very rare.. Case report:Schweiz Med Wochenschr. 1994 Apr 2;124(13):545-9. Med J Aust. 1980 Mar 22;1(6):283-4.

  • 6. Alopecia

    • Very rare.. Case report: Arch Dermatol. 1968 Jul;98(1):104.

  • 7. Angioimmunoblastic lymphadenopathy

    • Very rare.. Case report: Acta Med Okayama. 1981 Oct;35(4):263-72.

  • 8. Anorexia

    • Rare.

  • 9. Aplastic anemia

    • Very rare.. References: Am J Hematol. 1999 Jul;61(3):209-11.

  • 10. Arthralgia

    • Very rare.. Related to drug hypersensitivity syndrome. Discontinue administration.

  • 11. Aseptic meningitis

    • Very rare.. References: Pharmacotherapy. 2001 Aug;21(8):1007-9. Presse Med. 2004 Sep 11;33(15):1008-9. J Urol. 2000 Dec;164(6):2028.

  • 12. Cataracts

    • Very rare. Increased risk in patients taking the drug for a long time (cumulative dose greater than 400 g or more than three years of treatment).. Case report:Arch Ophthalmol. 1998 Dec;116(12):1652-6.

  • 13. Catatonia

    • Very rare. Hypersensitivity.. Case report:BMJ. 1991 Apr 20;302(6782):970.

  • 14. Cholestasis

    • Very rare.. Case report: Rev Esp Enferm Apar Dig. 1989 Mar;75(3):317-8.

  • 15. Cystitis

    • Very rare.. References: Br J Urol. 1997 May;79(5):817.

  • 16. Diarrhea

    • Rare.

  • 17. Disseminated granuloma annulare

    • Very rare.. References: Hautarzt. 1996 Feb;47(2):143.

  • 18. Ductopenia (vanishing bile duct syndrome)

    • Very rare.. References: Korean J Hepatol. 2005 Mar;11(1):80-5.Abstract.

  • 19. Eczema

    • Rare.

  • 20. Eosinophilia

    • Rare.

  • 21. Eosinophilic pustular folliculitis

    • Rare. Papulopustular eruption within weeks of starting treatment.. References: Australas J Dermatol. 2006 Nov;47(4):270-3.

  • 22. Epigastric pain

    • Rare.

  • 23. Erythema multiforme

    • Rare.

  • 24. Fatigue, weakness

    • Rare.

  • 25. Fever

    • Very rare.. Case report:Rev Clin Esp. 1988 Feb;182(2):119.

  • 26. Fixed erythema

    • Very rare.. References: Med Clin (Barc). 1996 Jan 27;106(3):119.

  • 27. Gout

    • Rare.. Avoid concurrent use of colchicine treatment in initial periods.

  • 28. Gynecomastia

    • Very rare.. Case report:Hautarzt. 1998 May;49(5):382-7.Abstract

  • 29. Hand and foot deformity (fingers telescopic)

    • Very rare. Patients with Tophaceous gout in prolonged treatment.. Case report: JAMA. 1977 Oct 10;238(15):1663-4.

  • 30. Headache

    • Frequent.

  • 31. Hepatic enzymes increased

    • Rare.

  • 32. Hepatic granuloma

    • Very rare.. Case report:Br Med J. 1978 May 20;1(6123):1320-1.

  • 33. Hepatic necrosis

    • Very rare. Course fatal.. References: Acta Med Port. 1998 Dec;11(12):1141-4.

  • 34. Hepatic veno-occlusive disease

    • Very rare. No well-established relationship.. Case report: Gastroenterol Jpn. 1981 Dec;16(6):616-22.

  • 35. Hepatitis

    • Very rare. Potentially deadly.. Related to hypersensitivity. case report: Arthritis Rheum. 1977 Nov-Dec, 20 (8) :1546-9. Drug Intell Clin Pharm. 1985 Jun; 19 (6) :431-3.

  • 36. Hypersensitivity reactions

    • Rare. The diagnosis is based on two major criteria (skin rash, worsening of renal function, liver toxicity) or one major and one minor (fever, eosinophilia, leukocytosis) in the absence of another cause... Sometimes fatal, force, usually a drug withdrawal.

  • 37. Ichthyosis

    • Very rare.. Case report: Arch Dermatol. 1968 Jul;98(1):104.

  • 38. Increased bilirubin

    • Very rare.. Direct hyperbilirubinemia

  • 39. Leukopenia

    • Very rare.. Case report:Br Med J. 1980 May 10;280(6224):1163.

  • 40. Lichen planus

    • Very rare. Most frequently, lichenoid reactions in the oral mucosa.. Case report:Pharmacotherapy. 1994 Sep-Oct;14(5):561-71. Oral Surg Oral Med Oral Pathol. 1984 Oct;58(4):397-400.

  • 41. Lyell's syndrome

    • Rare.. Case report:N Engl J Med. 1995 Dec 14;333(24):1600-7.

  • 42. Lymphadenopathy

    • Very rare.. Related to drug hypersensitivity syndrome. Discontinue administration.

  • 43. Macrocytosis

    • Very rare. Cases reported in association with leukopenia (concurrent treatment with azathioprine).. Case report: Neurology. 1986 Jan;36(1):35-9.

  • 44. Macular lesion

    • Very rare. No well-established relationship.. Case report: Arch Ophthalmol. 1968 Jun;79(6):786-7.

  • 45. Myocardial Infarction

    • Very rare. A case reported in combination therapy with enalapril, probably by anaphylaxis... Case report: Chest. 1995 Aug;108(2):586.

  • 46. Nephrolithiasis

    • Very rare.. Case report: Ann Intern Med. 1980 Mar;92(3):384-5. J Urol. 1985 Apr;133(4):658-9. Urol Int. 1985;40(3):138-40.

  • 47. Neutropenia

    • Very rare.. Case report:Br Med J. 1980 May 10;280(6224):1163.

  • 48. Pancytopenia

    • Very rare. Cases reported after coadministration of azathioprine.. References: Z Rheumatol. 2004 Oct;63(5):425-7. Ann Pharmacother. 1996 Sep;30(9):951-4. Transplantation. 1996 Jun 15;61(11):1661-2.

  • 49. Peripheral neuropathy

    • Very rare. Hypersensitivity reaction... Case report: Med Clin (Barc). 1994 Feb 12;102(5):178-80.

  • 50. Rhabdomyolysis

    • Very rare.. References: Nippon Jinzo Gakkai Shi. 2002 Jan;44(1):50-3. Abstract.

  • 51. Sickness

    • Frequent.

  • 52. Skin rash

    • Frequent.. More common in patients receiving penicillin derivatives or with renal failure

  • 53. Sleepiness

    • Rare.

  • 54. Steatorrhea

    • Very rare.. Case report: Br Med J (Clin Res Ed). 1982 Jun 26;284(6333):1914.

  • 55. Stevens-Johnson syndrome

    • Very rare.. Potentially fatal. references: Lancet. 1984 February 25, 1 (8374): 463.Ann Pharmacother. 1993 Mar, 27 (3) :337-43. Rev Invest Clin. 1995 Sep-Oct, 47 (5) :409-13.

  • 56. Thrombocytopenia

    • Very rare.. Case report:Drug Intell Clin Pharm. 1981 Apr;15(4):286-7.

  • 57. Urticaria

    • Very rare.

  • 58. Vasculitis

    • Very rare. Potentially serious hypersensitivity reaction.. The clinic includes toxic epidermal necrolysis, hepatic necrosis and renal failure, among other symptoms. reference: February West J Med 1977, 126 (2): 143-147.

  • 59. Vertigo

    • Frequent.

  • 60. Vomit

    • Rare.