May 23 2022

Adverse reactions to Ascorbic acid

  • 1. Bezoar
  • Very rare.. Case report: Ann Pharmacother. 1998 Sep;32(9):940-6.

  • 2. Chronic diarrhea
  • Very rare. In association with other substances. Relationship not well established... Case report: Gastroenterol Clin Biol. 1992;16(4):373.

  • 3. Contact dermatitis
  • Very rare. A patient treated with a cosmetic "rejuvenating" containing vitamin C... Case report: Contact Dermatitis. 2001 Nov;45(5):317.

  • 4. Dental erosion
  • In patients who chew gum containing vitamin C, by local demineralization and subsequent acidification... Case report: J Am Dent Assoc. 1983 Aug;107(2):253-6.

  • 5. Deposit on the cornea
  • Crystal deposition in the cornea in a patient treated with eye drops containing vitamin C... Case report: Med J Malaysia. 1999 Dec;54(4):526-7.

  • 6. Erythrocyte damage
  • In preterm infants exposed to ascorbate. Predisposes to hemolytic anemia by Heinz bodies production, including routine dose.. Case report: J Pediatr. 1988 Jul;113(1 Pt 1):114-20.

  • 7. Esophagitis
  • Very rare.. Case report:Gastroenterology. 1976 May;70(5 PT.1):766-9. Gastroenterol Clin Biol. 1983 Nov;7(11):868-76.

  • 8. Hematuria
  • Associated with hyperoxaluria. Predispose prolonged high doses of vitamin C.. Reference: Eur J Clin Invest. 1998 Sep;28(9):695-700.

  • 9. Hemolysis
  • Rare. In patients with paroxysmal nocturnal hemoglobinuria and G6PD deficiency... Case report: Am J Hematol. 1994 Dec;47(4):337-8. Lancet. 1994 Feb 5;343(8893):357. Lancet. 1990 Oct 13;336(8720):944.

  • 10. Hyperglycemia
  • A case of a 49 year old male patient who presented hyperglycemia reversible by ingestion of 4.5 grams per day of vitamin C... Case report: Diabetes Care. 1999 Jul;22(7):1218-9.

  • 11. Increased cardiovascular risk
  • Diabetic patients. No well-established relationship.. Cohort study: Am J Clin Nutr. 2004 Nov, 80 (5) :1194-200.

  • 12. Increased excretion of uric acid
  • In large quantities. Consider masking of gout and hyperuricemia by taking high doses.. Case report: Ann Intern Med. 1976 Apr;84(4):385-8.

  • 13. Insomnia
  • Frequent.

  • 14. Nephrolithiasis
  • Rare. By oxalates (urolithiasis)... References: Kidney Int. 2006 Nov;70(10):1672. J Nutr. 2005 Jul;135(7):1673-7. Prog Urol. 2003 Dec;13(6):1290-4.

  • 15. Oxaluria
  • Frequent.

  • 16. Pyrosis
  • Rare.

  • 17. Skin rash
  • Rare.

  • 18. Worsening congestive cardiomyopathy
  • In patients with hemochromatosis and ingestion of large amounts of vitamin C.. Case report: Aust N Z J Med. 1982 Apr;12(2):187-8.