Adverse reactions to Ascorbic acid

• 1. Bezoar

Very rare.. Case report: Ann Pharmacother. 1998 Sep;32(9):940-6.

• 2. Chronic diarrhea

Very rare. In association with other substances. Relationship not well established... Case report: Gastroenterol Clin Biol. 1992;16(4):373.

• 3. Contact dermatitis

Very rare. A patient treated with a cosmetic "rejuvenating" containing vitamin C... Case report: Contact Dermatitis. 2001 Nov;45(5):317.

• 4. Dental erosion

In patients who chew gum containing vitamin C, by local demineralization and subsequent acidification... Case report: J Am Dent Assoc. 1983 Aug;107(2):253-6.

• 5. Deposit on the cornea

Crystal deposition in the cornea in a patient treated with eye drops containing vitamin C... Case report: Med J Malaysia. 1999 Dec;54(4):526-7.

• 6. Erythrocyte damage

In preterm infants exposed to ascorbate. Predisposes to hemolytic anemia by Heinz bodies production, including routine dose.. Case report: J Pediatr. 1988 Jul;113(1 Pt 1):114-20.

• 7. Esophagitis

Very rare.. Case report:Gastroenterology. 1976 May;70(5 PT.1):766-9. Gastroenterol Clin Biol. 1983 Nov;7(11):868-76.

• 8. Hematuria

Associated with hyperoxaluria. Predispose prolonged high doses of vitamin C.. Reference: Eur J Clin Invest. 1998 Sep;28(9):695-700.

• 9. Hemolysis

Rare. In patients with paroxysmal nocturnal hemoglobinuria and G6PD deficiency... Case report: Am J Hematol. 1994 Dec;47(4):337-8. Lancet. 1994 Feb 5;343(8893):357. Lancet. 1990 Oct 13;336(8720):944.

• 10. Hyperglycemia

A case of a 49 year old male patient who presented hyperglycemia reversible by ingestion of 4.5 grams per day of vitamin C... Case report: Diabetes Care. 1999 Jul;22(7):1218-9.

• 11. Increased cardiovascular risk

Diabetic patients. No well-established relationship.. Cohort study: Am J Clin Nutr. 2004 Nov, 80 (5) :1194-200.

• 12. Increased excretion of uric acid

In large quantities. Consider masking of gout and hyperuricemia by taking high doses.. Case report: Ann Intern Med. 1976 Apr;84(4):385-8.

• 13. Insomnia

Frequent.

• 14. Nephrolithiasis

Rare. By oxalates (urolithiasis)... References: Kidney Int. 2006 Nov;70(10):1672. J Nutr. 2005 Jul;135(7):1673-7. Prog Urol. 2003 Dec;13(6):1290-4.

• 15. Oxaluria

Frequent.

• 16. Pyrosis

Rare.

• 17. Skin rash

Rare.

• 18. Worsening congestive cardiomyopathy

In patients with hemochromatosis and ingestion of large amounts of vitamin C.. Case report: Aust N Z J Med. 1982 Apr;12(2):187-8.