May 22 2022

Adverse reactions to Clavulanic acid

  • 1. Acute hepatitis
  • Rare.. Risk more than one case in a thousand patients exposed to the combination amoxicillin / clavulanate. Reference: Arch Intern Med 1996 Jun 24; 156 (12) :1327-32.

  • 2. Agranulocytosis
  • Rare. Relationship doubtful. A case with concurrent administration of vancomycin and ticarcillin-clavulanic acid.. References:Ann Pharmacother. 1997 Nov;31(11):1321-4.

  • 3. Cholestatic hepatitis
  • Rare.. References: Med J Aust. 1992 Oct 19;157(8):531. Singapore Med J. 1993 Oct;34(5):464-5. Ned Tijdschr Geneeskd. 1994 Jul 16;138(29):1481-3.Abstract.

  • 4. Hypersensitivity reactions
  • Rare.. References:J Allergy Clin Immunol. 1995 Mar;95(3):748-50. J Investig Allergol Clin Immunol. 2005;15(4):302-4.