Adverse reactions to Imatinib

• 1. Abdominal distension

Frequent.

• 2. Abdominal pain

Frequent.

• 3. Acral coldness

Infrequent.

• 4. Alopecia

Frequent.

• 5. Anasarca

Rare.

• 6. Anemia

Very frequent.

• 7. Angioedema

Rare.

• 8. Anorexia

Frequent.

• 9. Anxiety

Infrequent.

• 10. Arterial hypertension

Infrequent.

• 11. Arterial hypotension

Infrequent.

• 12. Arthralgia

Frequent.

• 13. Ascites

Infrequent.

• 14. Aseptic osteonecrosis

Rare.. Mainly the femoral head

• 15. Blood creatinine increased

Infrequent.

• 16. Blurred vision

Frequent.

• 17. Bone marrow depression

Infrequent.

• 18. Breast enlargement

Infrequent.

• 19. Bullous dermatitis

Infrequent.

• 20. Cardiac tamponade

Rare.

• 21. Cerebral edema

Rare.

• 22. Cerebral hemorrhage

Infrequent.

• 23. Cheilitis

Infrequent.

• 24. Colitis

Rare.

• 25. Conjunctival hemorrhage

Infrequent.

• 26. Conjunctivitis

Frequent.

• 27. Constipation

Frequent.

• 28. Cough

Infrequent.

• 29. Decreased appetite

Infrequent.

• 30. Decreased libido

Infrequent.

• 31. Dehydration

Infrequent.

• 32. Depression

Infrequent.

• 33. Dermatitis

Very frequent.. Including eczema and other rashes

• 34. Diarrhea

Frequent.

• 35. Diverticulitis

Rare.

• 36. Dry eye

Infrequent.

• 37. Dry mouth

Infrequent.

• 38. Dry skin

Frequent.

• 39. Dysgeusia

Frequent.

• 40. Dyspepsia

Frequent.

• 41. Dyspnoea

Frequent.

• 42. Ecchymosis

Infrequent.

• 43. Elevation of body temperature

Frequent.

• 44. Embolism

Rare.

• 45. Epistaxis

Frequent.

• 46. Exfoliative dermatitis

Infrequent.

• 47. Eye irritation

Infrequent.

• 48. Eyelid edema

Frequent.

• 49. Facial edema

Frequent.

• 50. Febrile neutropenia

Frequent.

• 51. Flatulence

Frequent.

• 52. Fluid retention

Frequent.

• 53. Flushing

Infrequent.

• 54. Frequent belching

Infrequent.

• 55. Gastric ulcer

Infrequent.

• 56. Gastroenteritis

Infrequent.

• 57. Gastroesophageal reflux

Frequent.

• 58. Gastrointestinal bleeding

Infrequent.. Melena or hematemesis

• 59. Gastrointestinal perforation

Rare.

• 60. General malaise

Infrequent.

• 61. Glaucoma

Rare.

• 62. Gout

Infrequent.

• 63. Gynecomastia

Infrequent.

• 64. Headache

Very frequent.

• 65. Heart failure

Infrequent.

• 66. Hematomas

Infrequent.

• 67. Hematuria

Infrequent.

• 68. Hemorrhage

Infrequent.

• 69. Hepatic enzymes increased

Frequent.

• 70. Hepatic insufficiency

Rare.

• 71. Hepatitis

Infrequent.

• 72. Herpes simplex

Infrequent.

• 73. Herpes zoster

Infrequent.

• 74. Hyperkalemia

Rare.

• 75. Hyperuricemia

Infrequent.

• 76. Hypoesthesia

Infrequent.

• 77. Hypokalemia

Infrequent.

• 78. Hyponatremia

Rare.

• 79. Hypophosphatemia

Infrequent.

• 80. Hypopigmentation of the skin

Infrequent.

• 81. Hypotrichosis

Infrequent.

• 82. Ileum

Rare.

• 83. Increased alkaline phosphatase

Infrequent.

• 84. Increased appetite

Infrequent.

• 85. Increased bilirubin

Infrequent.

• 86. Increased CK

Infrequent.

• 87. Increased intracranial pressure

Rare.

• 88. Increased sweating

Infrequent.

• 89. Increased tear secretion

Frequent.

• 90. Insomnia

Frequent.

• 91. Interference with the ability to drive or operate machinery

Treatment with imatinib can lead to dizziness or blurred vision, so potentially reduces the ability to operate machinery or driving.

• 92. Interstitial pneumonitis

Rare.

• 93. Intestinal obstruction

Rare.

• 94. Jaundice

Infrequent.

• 95. Joint inflammation

Very frequent.

• 96. Joint stiffness

Infrequent.

• 97. Joint stiffness

Infrequent.

• 98. Kidney pain

Infrequent.

• 99. LDH increase

Infrequent.

• 100. Macula edema

Rare.

• 101. Memory impairment

Infrequent.

• 102. Menorrhagia

Infrequent.

• 103. Mental confusion

Rare.

• 104. Migraine

Infrequent.

• 105. Muscular cramps

Very frequent.. Often accompanied by muscle spasms

• 106. Musculoskeletal pain

Very frequent.. Joint, muscle or bone

• 107. Neutropenia

Very frequent.

• 108. Night sweats

Frequent.

• 109. Onychoclasis

Infrequent.

• 110. Orbital edema

Infrequent.

• 111. Pancreatitis

Infrequent.

• 112. Pancytopenia

Infrequent.

• 113. Papilledema

Rare.

• 114. Paresthesias

Frequent.

• 115. Pericardial effusion

Rare.

• 116. Pericarditis

Rare.

• 117. Periorbital edema

Very frequent.

• 118. Peripheral edema

Frequent.

• 119. Peripheral neuropathy

Infrequent.

• 120. Petechiae

Infrequent.

• 121. Photosensitization

Infrequent.

• 122. Pleural effusion

Infrequent.

• 123. Pneumonia

Infrequent.

• 124. Polaquiuria

Infrequent.

• 125. Pruritus

Frequent.

• 126. Psoriasis

Infrequent.

• 127. Pulmonary edema

Infrequent.

• 128. Pulmonary fibrosis

Rare.

• 129. Purpura

Infrequent.

• 130. Renal failure

Infrequent.

• 131. Retinal hemorrhage

Rare.

• 132. Sciatica

Infrequent.

• 133. Scrotal edema

Infrequent.

• 134. Seizures

Rare.

• 135. Sepsis

Infrequent.

• 136. Sexual dysfunction

Infrequent.

• 137. Sickness

Frequent.

• 138. Skin hyperpigmentation

Infrequent.

• 139. Sleepiness

Infrequent.

• 140. Sore nipples

Infrequent.

• 141. Sore throat

Infrequent.

• 142. Stevens-Johnson syndrome

Rare.

• 143. Sweet syndrome

Rare.. Acute febrile neutrophilic dermatosis

• 144. Syncope

Infrequent.

• 145. Tachycardia

Infrequent.

• 146. Thrombocytopenia

Very frequent.

• 147. Thrombosis

Rare.

• 148. Tinnitus

Infrequent.

• 149. Tiredness, fatigability

Frequent.

• 150. Tumor necrosis

Rare.

• 151. Tumoral hemorrhage

Rare.

• 152. Ulcers in the oral mucosa

Frequent.

• 153. Upper respiratory infection

Infrequent.

• 154. Urticaria

Infrequent.

• 155. Vertigo

Frequent.

• 156. Vesicular dermatitis

Rare.

• 157. Vitreous hemorrhage

Rare.

• 158. Vomit

Frequent.

• 159. Weakness

Frequent.

• 160. Weight gain

Frequent.

• 161. Weight loss

Infrequent.