Adverse reactions to Irbesartan

• 1. Acute pancreatitis

Very rare, one case in a patient receiving irbesartan and hydrochlorothiazide combination. The authors attribute the case to irbesartan.. Ann Pharmacother. 2002 Dec;36(12):1883-6

• 2. Acute renal failure

Case report. A 67 year old patient who received irbesartan along with other drugs by suffering heart failure, showed oliguric renal failure that reproduced by losartan irbesartan changing.. Am J Med. 2001 Aug;111(2):162-3

• 3. Allergy in its various manifestations (asthma, rhinitis, urticaria, angioedema)

Very rare.

• 4. Altered taste

Very rare.

• 5. Anemia

In dialysis patients. Class effect. Mechanism not established... Lancet. 1998 Jul 25;352(9124):286

• 6. Arthralgia

Very rare.

• 7. Autoimmune hepatitis

A case report. The process relapse after discontinuation of immunosuppressive therapy. No well-established mechanism.. Eur J Gastroenterol Hepatol. 2005

• 8. Chest pain

Infrequent.

• 9. Cholestatic hepatitis

Case report.. BMJ 2000;321:547.

• 10. Cough

Postmarketing communication.. ADRAC Bulletin 1999;18:2

• 11. Decreased blood hemoglobin

Frequent.. No known clinical significance

• 12. Diarrhea

Infrequent.

• 13. Dizziness

Frequent.

• 14. Dyspepsia

Infrequent.

• 15. Facial edema

Case report: involvement of the neck, face and eyelids. The case was not reversible after drug withdrawal.. J Drugs Dermatol. 2002 Dec;1(3):329-30

• 16. Facial redness

Rare.

• 17. Headache

Very rare.

• 18. Hepatic enzymes increased

Very rare.

• 19. Hepatitis

Very rare.

• 20. Hyperkalemia

Frequent.. Diabetics

• 21. Impaired renal function

Very rare.

• 22. Increased CK

Frequent.. No clinical significance for now

• 23. Interference with the ability to drive or operate machinery

Related to the possibility of producing dizziness.

• 24. Leukocytoclastic vasculitis

Very rare.

• 25. Muscle pain

Frequent.

• 26. Muscular cramps

Very rare.

• 27. Orthostatic dizziness

Frequent.

• 28. Orthostatic hypotension

Frequent.

• 29. Psoriasis

Nine cases reported with sartans , of which two corresponded to irbesartan. Class effect.. Br J Dermatol. 2002 Sep;147(3):617-8

• 30. Pyrosis

Infrequent.

• 31. Renal failure

Very rare.. In patients at risk

• 32. Sexual dysfunction

Infrequent.

• 33. Sickness

Frequent.

• 34. Tachycardia

Infrequent.

• 35. Tinnitus

Very rare.

• 36. Tiredness, fatigability

Frequent.

• 37. Vomit

Frequent.