Adverse reactions to Sodium valproate
- 1. Acne
- 2. Acute intermittent porphyria, aggravation
- 3. Acute pancreatitis
- 4. Acute renal failure
- 5. Aggressiveness, violent behavior
- 6. Allergy in its various manifestations (asthma, rhinitis, urticaria, angioedema)
- 7. Alopecia
- 8. Anorexia
- 9. Aplastic anemia
- 10. Ataxia
- 11. Bulimia
- 12. Cerebral edema
- 13. Coagulation disorder
- 14. Cognitive disorder
- 15. Coma
- 16. Complex metabolic syndrome
- 17. Cytolytic hepatitis
- 18. Dementia
- 19. Depression
- 20. Diarrhea
- 21. Diplopia
- 22. Dysarthria
- 23. Encephalopathy
- 24. Enuresis
- 25. Epigastric pain
- 26. Erythema multiforme
- 27. Erythroblastopenia
- 28. Extrapyramidal syndrome
- 29. Fanconi syndrome
- 30. Fatigue, weakness
- 31. Fetal valproate syndrome
- 32. Fulminant hepatitis
- 33. Growth retardation
- 34. Gynecomastia
- 35. Hallucinations
- 36. Headache
- 37. Hepatic encephalopathy
- 38. Hepatic enzymes increased
- 39. Hepatic insufficiency
- 40. Hirsutism
- 41. Hyperactivity
- 42. Hyperammonemia
- 43. Hyperandrogenism
- 44. Hyperglycinemia
- 45. Hypersensitivity reactions
- 46. Hypoacusia
- 47. Hypothermia
- 48. Hypothyroidism
- 49. Increased bilirubin
- 50. Increased blood amylase
- 51. Increased excretion glycine
- 52. Increased GGT
- 53. Insomnia
- 54. Intentional tremor
- 55. Interference with the ability to drive or operate machinery
- 56. Lengthening of bleeding time
- 57. Leukopenia
- 58. Local inflammation
- 59. Lupus erythematosus
- 60. Lyell's syndrome
- 61. Macrocytic anemia
- 62. Male sterility
- 63. Menstrual disorders
- 64. Mental confusion
- 65. Metabolic acidosis
- 66. Muscular hypotonia
- 67. Nightmares
- 68. Nystagmus
- 69. Osteoporosis
- 70. Parkinsonian syndrome
- 71. Pericarditis
- 72. Peripheral edema
- 73. Polycystic ovary
- 74. Psychomotor agitation
- 75. Psychomotor retardation
- 76. Purpura
- 77. Rhabdomyolysis
- 78. Sedation
- 79. Seizures
- 80. Sickness
- 81. Skin rash
- 82. Sleepiness
- 83. Status epilepticus
- 84. Stevens-Johnson syndrome
- 85. Stomatitis
- 86. Syndrome of inappropriate secretion of ADH
- 87. Thrombocytopenia
- 88. Vasculitis
- 89. Vomit
- 90. Weight gain
Rare.
Case report.
Very rare.
Case report.
Rare.
Frequent.
Rare.. References: Epilepsia. 2006 Jul;47(7):1232-6.
Rare.
Muy rara. Potencialmente fatal.. Case report: Pediatr Crit Care Med. 2006 May;7(3):273-6. Int J Clin Pharmacol Ther. 1997 Sep;35(9):353-6. J Toxicol Clin Toxicol. 1992;30(4):685-6.
Very rare. It is believed that induction of von Willebrand disease type I due to valproic acid.. Case report: J Child Neurol. 2002 Jan;17(1):41-3. Lancet. 1990 Jun 2;335(8701):1350-1.
Very rare.. Case report : Epilepsia. 2006 Dec;47(12):2183-5. Pharmacopsychiatry. 2006 Jan;39(1):9-12. Reversible and often associated with parkinsonian syndrome.
Case report.
Very rare.. Include polycystic ovarian hyperandrogenism, insulin resistance and hyperinsulinemia, obesity, hypertriglyceridemia, and low HDL cholesterol.
Reversible.. Very rare
Frequent.
Very rare.
Rare. Usually associated with hyperammonemia... Case report: Pediatr Neurol. 2006 Nov;35(5):356-8. Eur J Neurol. 2006 Oct;13(10):e5-6. Seizure. 2006 Sep;15(6):443-8.
No well-established relationship.
Frequent.
Rare.
Case report.
No well-established relationship.
Case report.
Rare.
Rare. Variable risk, depending on dose and time of administraci?n.reference: Indian J Pediatr. 2006 Oct, 73 (10) :937-9. .. The syndrome includes neural tube, heart, mouth, genitals and members, and other less frequent.
Case report.
Very rare.
No well-established relationship.
Very rare.
Frequent.
Very rare.
Rare.
Rare. Occasionally fatal... Case report: Acad Emerg Med. 2001 Oct;8(10):999-1001.Lancet. 1999 Apr 24;353(9162):1408.
Frequent. It is often associated with obesity and polycystic ovary... References:Ann Neurol. 1996 May;39(5):579-84. Ann Neurol. 1999 Apr;45(4):444-50. An Pediatr (Barc). 2003 May;58(5):443-8.
Rare. Occasionally fatal... Case report: Am J Psychiatry. 2004 Mar;161(3):579.
Very rare.. Reversible or irreversible. Not well-established relationship
Rare.
Case report.
Very rare.
Very rare.. Case report: Pediatrics. 2006 Oct;118(4):1660-3. Rev Gastroenterol Peru. 2006 Jul-Sep;26(3):318-23.
Rare.
No well-established relationship.
Possible transient sleepiness. Consider the associated medications that may potentiate the effect of valproate.
Verify coagulation status before surgery.
Rare.
At the point of injection.. In parenteral treatment
Very rare.. Case report: Epilepsia. 1990 May-Jun;31(3):343-5. Epilepsia. 1996 Jun;37(6):587-8.
Rare.. Case report: Lancet. 1999 Jun 26;353(9171):2190-4.
Infrequent.. References: J Child Adolesc Psychopharmacol. 2005 Dec;15(6):1011-4. J Clin Psychiatry. 1997 Mar;58(3):125.
Infrequent.. References:Neurology. 2004 Jan 27;62(2):247-53. Epilepsia. 1999 Apr;40(4):520-1. Eur J Neurol. 2005 Feb;12(2):118-24.
No well-established relationship.
No well-established relationship.
No well-established relationship.
Induced carnitine deficiency by valproate.
Rare.
Very rare.. Case report: Pharmacol Res. 2004 Jul;50(1):93-7. Neth J Med. 2005 Jun;63(6):222-6. J Pediatr. 1996 Mar;128(3):441.
Rare. Reversible.. Case report: Encephale. 2005 Jan-Feb;31(1 Pt 1):98-101.Epilepsia. 2006 Dec;47(12):2183-5.
Very rare.. Case report : Presse Med. 2001 Jan 20;30(2):62-3. A case of febrile pleuropericarditis.
Very rare.. Case report: Therapie. 2002 Mar-Apr;57(2):194-6. Ann Pharmacother. 1999 Dec;33(12):1370-1.
No well-established relationship.
Rare. Often reversible... Case report: Pediatr Neurol. 2003 May;28(5):382-4. Pediatr Neurol. 2006 Nov;35(5):356-8.
Induction of IgM antiplatelet.
Case report.
Common when starting treatment.
Very rare.
Frequent.. Increased incidence the beginning of treatment
Rare.. At start of treatment
Very rare.
Rare.. Case report: Lancet. 1999 Jun 26;353(9171):2190-4.
No well-established relationship.
Case report.
Infrequent.. References: Pharmacotherapy. 2001 Nov;21(11):1325-30. Epilepsia. 2006 Jul;47(7):1136-43.
Very rare.
Frequent.
Infrequent.