Adverse reactions to Trastuzumab

• 1. Abdominal pain

Frequent.

• 2. Abnormal thoughts

Rare.. No well-established relationship

• 3. Acne

Frequent.

• 4. Alopecia

Frequent.

• 5. Anaphylactic shock

Rare.. No well-established relationship

• 6. Anemia

Rare.

• 7. Angioedema

Infrequent.. No well-established relationship

• 8. Anorexia

Frequent.

• 9. Anxiety

Frequent.

• 10. Arterial hypotension

Frequent.

• 11. Arthralgia

Frequent.

• 12. Arthritis

Frequent.

• 13. Asthma, bronchospasm

Frequent.

• 14. Ataxia

Infrequent.. No well-established relationship

• 15. Backache

Frequent.

• 16. Bone pain

Frequent.

• 17. Bradycardia

Rare.. No well-established relationship

• 18. Cardiogenic shock

Rare.. No well-established relationship

• 19. Cardiomyopathy

Frequent.

• 20. Cellulitis

Rare.. No well-established relationship

• 21. Cerebral edema

Rare.. No well-established relationship

• 22. Cerebrovascular alteration

Rare.. No well-established relationship

• 23. Cervical pain

Frequent.

• 24. Chest pain

Frequent.

• 25. Chills

Frequent.. Relating to drug infusion

• 26. Coma

Rare.. No well-established relationship

• 27. Constipation

Frequent.

• 28. Cough, increased

Frequent.

• 29. Deafness

Rare.. No well-established relationship

• 30. Decreased ejection fraction

Rare.. No well-established relationship

• 31. Depression

Frequent.

• 32. Diarrhea

Frequent.

• 33. Dry mouth

Frequent.

• 34. Dry skin

Frequent.

• 35. Dysgeusia

Frequent.

• 36. Dyspepsia

Frequent.

• 37. Dyspnoea

Frequent.

• 38. Ecchymosis

Frequent.

• 39. Epistaxis

Frequent.

• 40. Erisipela

Rare.. No well-established relationship

• 41. Fatigue, weakness

Frequent.

• 42. Febrile neutropenia

Frequent.. These figures also include patients labeled as neutropenic sepsis and neutropenia associated with fever (and antibiotic use).

• 43. Fever

Frequent.. Relating, in general, to drug infusion

• 44. Flu-like syndrome

Frequent.

• 45. General malaise

Frequent.

• 46. Glomerulonephritis

Rare.. No well-established relationship

• 47. Headache

Frequent.

• 48. Heart failure

Frequent.. Occasionally, worsening of previous failure

• 49. Hemorrhoids

Frequent.

• 50. Hepatic insufficiency

Rare.. No well-established relationship

• 51. Hepatitis

Rare.. No well-established relationship

• 52. Hyperkalemia

Rare.. No well-established relationship

• 53. Hypersensitivity reactions

Frequent.

• 54. Hypoesthesia

Frequent.

• 55. Hypoprothrombinemia

Rare.. No well-established relationship

• 56. Hypoxia

Rare.. No well-established relationship

• 57. Increased sweating

Frequent.

• 58. Increased tear secretion

Frequent.. Comparative data from the clinical trial M77001

• 59. Infections

Frequent.

• 60. Insomnia

Frequent.

• 61. Jaundice

Rare. No well-established relationship..

• 62. Laryngeal edema

Rare.. No well-established relationship

• 63. Leukemia

Rare.. No well-established relationship

• 64. Leukopenia

Frequent.

• 65. Liver decreased consistency

Frequent.. By abdominal palpation

• 66. Lymphedema

Frequent.. M77001 trial comparative data

• 67. Mastitis

Frequent.

• 68. Membranous glomerulonephritis

Rare.. No well-established relationship

• 69. Meningitis

Rare.. No well-established relationship

• 70. Muscular cramps

Frequent.. In extremities

• 71. Muscular hypertonia

Frequent.

• 72. Myalgia

Frequent.

• 73. Nail disorder

Frequent.

• 74. Neoplasia, progression

Rare.. No well-established relationship

• 75. Neutropenia

Rare.. No well-established relationship

• 76. Pain

Frequent.

• 77. Palpitations

Frequent.

• 78. Pancreatitis

Rare.. No well-established relationship

• 79. Papilledema

Rare.. No well-established relationship

• 80. Paraneoplastic brain degeneration

Rare.. Relaci?n no bien establecida

• 81. Paresis

Rare.. No well-established relationship

• 82. Paresthesias

Frequent.

• 83. Pericardial effusion

Rare.. No well-established relationship

• 84. Pericarditis

Rare.. No well-established relationship

• 85. Peripheral edema

Frequent.

• 86. Peripheral neuropathy

Frequent.

• 87. Pharyngitis

Frequent.

• 88. Pneumonia

Rare.. No well-established relationship

• 89. Pneumonitis

Rare.. No well-established relationship

• 90. Pruritus

Frequent.

• 91. Pulmonary disorders

Frequent.

• 92. Pulmonary edema

Rare. Acute presentation.. No well-established relationship

• 93. Pulmonary fibrosis

Rare.. No well-established relationship

• 94. Pulmonary infiltrate

Rare.. No well-established relationship

• 95. Renal failure

Rare.. No well-established relationship

• 96. Respiratory insufficiency

Rare.. No well-established relationship

• 97. Retinal hemorrhage

Rare.. No well-established relationship

• 98. Rhinitis

Frequent.

• 99. Rhinorrhea

Frequent.

• 100. Sepsis

Rare.. No well-established relationship

• 101. Sickness

Frequent.

• 102. Sinusitis

Frequent.

• 103. Skin rash

Frequent.

• 104. Sleepiness

Frequent.

• 105. Stevens-Johnson syndrome

Rare.. No well-established relationship

• 106. Stiffness

Frequent.

• 107. Supraventricular tachyarrhythmia

Frequent.

• 108. Thrombocytopenia

Rare.. No well-established relationship

• 109. Thrombocytopenia

Rare.. No well-established relationship

• 110. Tremor

Frequent.

• 111. Urinary infection

Frequent.

• 112. Urticaria

Rare.. No well-established relationship

• 113. Vasodilatation

Frequent.

• 114. Vomit

Frequent.

• 115. Weight gain

Frequent.. Comparative data from the clinical trial M77001

• 116. Weight loss

Frequent.