Do not use imipramine
If you are allergic (hypersensitive) to imipramine, to other tricyclic antidepressants or any of the other ingredients of the medicinal product prescribed to you. If you think may be allergic, ask your doctor.
Allergy symptoms may include:
- Asthma attacks with shortness of breath, audible wheezing or rapid breathing.
- More or less sudden swelling of the face, lips, tongue or elsewhere in the body. It is especially critical if it affects the vocal cords.
- Hives, itching, rash
- Anaphylactic shock (loss of consciousness, paleness, sweating, etc.).
Nor you should take this medicine:
- If you suffer from cardiac disorders such as irregular heartbeat (arrhythmia), heart block or have recently had a heart attack
- If you have episodes of mania
- If you have a severe liver disease
- If you have porphyria (a genetic disorder of hemoglobin in blood which causes blistering rash, abdominal pain, and nervous system disorders)
- If you can not swallow water
- If you have increased eye pressure (glaucoma)
- If you are taking monoamine oxidase inhibitors (MAOIs) or have been taking any of these drugs during the previous two weeks
- If the patient is younger than six years
Take special care with imipramine
Suicidal thoughts or worsening of depression or anxiety disorder
If you are depressed or have an anxiety disorder may have sometimes thought of harming or killing yourself. These side effects may be increased when you start treatment with antidepressants since these medicines take a time up to be effective, usually two weeks, although this period may be longer.
You may suffer more likely these thoughts:
- If you have previously had these thoughts of harming or killing yourself
- If you are a young adult.
The information from clinical trials has shown an increased risk of suicidal behavior in young adults (under 25 years) with psychiatric conditions who were treated with antidepressants.
If you have thoughts of harming yourself or suicidal, contact your doctor or go to the hospital immediately.
It may be useful to tell a relative or friend that you are depressed or have anxiety and ask them to read the leaflet that accompanies the medication container.
You can ask to tell you whether they think your depression or anxiety is getting worse or if are worried about your behavior.
Before taking imipramine, check with your doctor if you or your child (if he is the patient):
- You have any psychiatric disorder such as schizophrenia or a manic depressive psychosis
- You are trying or have recently gotten give up alcohol or you are in the process of gradua1 withdrawal an antiepileptic treatment.
- You have or have had glaucoma or prostatic hypertrophy.
- You have an overactive thyroid or are being treated for any thyroid disease.
- You have a history of epilepsy or brain damage.
- You have low blood pressure or poor blood circulation.
- Have a severe kidney disease
- Have a tumor of the adrenal glands, such as pheochromocytoma or neuroblastoma.
- Suffer panic attacks.
- Have longstanding constipation.
- You use contact lenses.
- You are receiving electroconvulsive treatment.
- You should be subjected to any surgery, including dental surgery involving anesthesia.
Laboratory tests
While taking this medication, your doctor will monitor regularly your liver function or blood cell levels.
Dental checkups
It is advisable regularly checking the condition of teeth by your dentist since imipramine can cause dental problems.
Consult your doctor, even if any of the above circumstances have only happened once.
Taking other medicines
Tell your doctor or pharmacist if you are taking or have recently taken any other medicines, including herbal products or drugs obtained without a prescription.
Tell your doctor especially if you are taking:
- Medicines to treat epilepsy, as barbiturates, phenytoin, carbamazepine, etc.
- Benzodiazepines, as diazepam, nitrazepam, oxazepam, alprazolam,
- Antidepressant medications including selective inhibitors of serotonin reuptake [SSRIs] (fluoxetine, fluvoxamine, etc)
- Disulfiram for the treatment of alcohol addiction.
- Treatment with nicotine for smoking cessation.
- Methylphenidate used to treat attention deficit and hyperactivity disorder,
- Anticoagulant drugs (warfarin)
- Antihistamines (medicines to treat allergies),
- Altretamine (to treat some cancers)
- Apraclonidine and brimonidine (for the treatment of glaucoma)
- Baclofen (a muscle relaxant),
- Analgesics as tramadol, codeine, dihydrocodeine.
- Some medicines for treating a heart disease, such as diltiazem, verapamil, labetalol, propranolol or quinidine
- Medicines to treat angina, applied by sprays or dissolved under the tongue, as nitroglycerin or isosorbide dinitrate.
- Drugs for treatment of arterial hypertension as guanethidine, debrisoquine, methyldopa, reserpine, clonidine or diuretics
- Medicines to treat some mental illnesses, such as thioridazine or chlorpromazine
- Cimetidine, medicine to treat stomach ulcers
- Entacapone or selegiline used to treat Parkinson's disease,
- Oral contraceptives or hormone replacement therapy
- Appetite-slowing
- Sympathomimetic drugs as adrenaline, ephedrine, isoprenaline, noradrenaline, phenylephrine and phenylpropanolamine (this last may be present in medicines sold without prescription for cold symptoms).
- Ritonavir, a medicine for treatment of AIDS
Use with food and beverages
You should not consume alcohol with this medication.
Consult your doctor or pharmacist before taking any medicine.
Special physiological situations
Always consult your doctor or pharmacist before taking any medicine during pregnancy or lactation.
Pregnancy and lactation
This medicine should not be taken during pregnancy or breastfeeding.
If you take imipramine during the last three months of pregnancy, the baby may be born with breathing difficulties, lethargy, colic, irritability, changes in blood pressure, tremors and spasms. If its administration is considered necessary during pregnancy, it should be discontinued seven weeks before the expected date of delivery.
Use in children
Not for use in children under six.
Driving and using machines
Imipramine can alter alertness and cause drowsiness and blurred vision. These symptoms can be aggravated by alcohol intake.
Before driving or operating machinery should make absolutely sure that imipramine does not affect you for these tasks.
Consult your doctor or pharmacist before taking any medicine.
Like all medicines, imipramine can cause side effects, although not everybody gets them.
The frequency of side effects is classified into:
Very common: affect 1 out of 1-10 patients
Common: affect 1 out of 10-100 patients
Uncommon: affect 1 out of 100-1.000 patients
Rare: affect 1 out of 1.000-10.000 patients
Very Rare: affect less than 1 in 10,000 patients
Incidence not known: Can not be established the true incidence from the available data
Discontinue treatment and consult immediately with your doctor
If you have any of the following allergic reactions: pneumonitis (fever, chills, cough, shortness of breath, unusual weight loss, feeling of being ill), skin rash (which can be itchy), sensitivity to sun or sun lamps, swelling of the face or tongue, which is potentially serious if it causes breathing difficulty (angioedema), shock and collapse.
Tell your doctor if you experience any of the following side effects:
Blood side effects: Reduction of some type of blood cell. You may experience a sore throat, mouth ulcers, pain or frequent bleeding and recurrent infections.
Metabolic and endocrine side effects: Disorders of sexual function or sexual desire, swelling of the breasts (gynecomastia), both women and men, overproduction of milk in lactating women (galactorrhoea), changes in blood glucose, loss or weight gain, syndrome of inappropriate secretion of antidiuretic hormone.
Nervous side effects: disorientation, vertigo, tiredness, weakness, headache, difficulty concentrating, confusion, agitation, mood changes, aggressiveness, difficulty sleeping, hallucinations, anxiety, restlessness, pricking sensation, tremor, muscle spasms or lack of muscle control, speech disorder and seizures.
Anticholinergic side effects: Dry mouth, blurred vision or double vision, constipation, sweating, hot flushes, difficulty urinating or urinary retention, pupil dilation, glaucoma and intestinal paralysis.
Cardiovascular side effects: Dizziness upon standing, low or high blood pressure, tachycardia, palpitations, arrhythmia (irregular heartbeat), electrocardiographic changes.
Digestive side effects: gastrointestinal discomfort, loss of appetite, inflammation of the oral mucosa, tongue lesions.
Liver side effects: Impaired liver function, jaundice, alterations in liver function tests.
Other: Hair loss, petechiae
Withdrawal symptoms: feeling unwell, upset stomach, diarrhea, difficulty sleeping, nervousness, anxiety, headaches, irritability
This list does not include all adverse reactions associated with the use of imipramine, both well established as those that are under consideration or confirmation. In case you feel unwell, should immediately consult with the doctor who prescribed this medicine.
If you notice any side effects not listed in this website or in the leaflet accompanying the package, ask your doctor or pharmacist.
If any of the side effects gets serious, tell your doctor or pharmacist.
This page contains a list of brands of authorized pharmaceutical specialties of the active principle imipramine in the countries listed below:
[ Australia] [ Brazil] [ Canada] [ France] [ Germany] [ India] [ Italy] [ Japan] [ Mexico] [ Pakistan] [ Puerto Rico] [ Spain] [ Turkey] [ United Kingdom] [ U.S.A]
Given the nature of the pharmaceutical market, some specialties may be unavailable, have been removed from the pharmaceutical market or have changed its name. So that, in no case can take decisions based on the information contained in the page. MEDIZZINE is not responsible for any damage arising from the information provided, which may be incomplete or outdated.
Warning:
With exceptions expressly indicated, these lists do not include active principle associations with other drugs or clinical use containers.
Australia: ▲
MELIPRAMINE 25 mg, tablets
TOFRANIL 10 mg, tablets
TOFRANIL 25 mg, tablets
TOLERADE 10 mg, tablets
TOLERADE 25 mg, tablets
Brazil: ▲
IMIPRAX 10 mg, tablets
IMIPRAX 25 mg, tablets
MEPRAMIN 10 mg, tablets
MEPRAMIN 25 mg, tablets
TOFRANIL 10 mg, dragees
TOFRANIL 25 mg, dragees
TOFRANIL PAMOATO 75 mg, capsules
TOFRANIL PAMOATO 75 mg, tablets
TOFRANIL PAMOATO 150 mg, capsules
TOFRANIL PAMOATO 150 mg, tablets
Canada: ▲
IMIPRAMINE AA PHARMA 10 mg, tablets
IMIPRAMINE AA PHARMA 25 mg, tablets
IMIPRAMINE AA PHARMA 50 mg, tablets
IMIPRAMINE AA PHARMA 75 mg, tablets
NOVO-PRAMINE 10 mg, tablets
NOVO-PRAMINE 25 mg, tablets
NOVO-PRAMINE 50 mg, tablets
PMS IMIPRAMINE 10 mg, tablets
PMS IMIPRAMINE 25 mg, tablets
PMS IMIPRAMINE 50 mg, tablets
France: ▲
TOFRANIL 10 mg, tablets
TOFRANIL 25 mg, tablets
Germany: ▲
IMIPRAMIN-NEURAXPHARM 10 mg, tablets
IMIPRAMIN-NEURAXPHARM 25 mg, tablets
IMIPRAMIN-NEURAXPHARM 100 mg, tablets
TOFRANIL 25 mg, dragees
India: ▲
ANTIDEP 25 mg, tablets
ANTIDEP 75 mg, tablets
ANTIPRES 25 mg, tablets
ANTIPRES 50 mg, tablets
ANTIPRES 75 mg, tablets
DEPIK 25 mg, tablets
DEPIK 75 mg, tablets
DEPRANIL 25 mg, tablets
DEPRANIL 75 mg, tablets
DEPSOL 25 mg, tablets
DEPSOL 75 mg, tablets
DEPSONIL 25 mg, tablets
DEPSONIL-PLUS 75 mg, capsules
DEPSONIL-PM 75 mg, capsules
DIAMIN 75 mg, tablets
ELAMIN 25 mg, tablets
ELAMIN 75 mg, tablets
ELDEP 25 mg, tablets
ELDEP 50 mg, tablets
ELDEP 75 mg, tablets
IMIRISE 25 mg, tablets
IMIRISE 75 mg, tablets
IMIPRAMINE SUN 25 mg, tablets
IMIPRAMINE SUN 75 mg, capsules
IMPRINE 25 mg, tablets
MICRODEP 25 mg, tablets
Italy: ▲
TOFRANIL 10 mg, tablets
TOFRANIL 25 mg, tablets
Japan: ▲
IMIDOL 10 mg, dragees
IMIDOL 25 mg, dragees
TOFRANIL 10 mg, tablets
TOFRANIL 25 mg, tablets
Mexico: ▲
FIXON 25 mg, 20 dragees
TALPRAMIN 10 mg, 60 tablets
TALPRAMIN 25 mg, 20 & 60 tablets
TALPRAMIN 50 mg, 20 tablets
TOFRANIL 10 mg, 60 dragees
TOFRANIL 25 mg, 20 dragees
TOFRANIL PM 75 mg, 16 capsules
Pakistan: ▲
DEPNA 25 mg, tablets
IMIDOL 25 mg, tablets
IMIPRAL 25 mg, tablets
IMIPRAMIN 25 mg, tablets
IMIPRAMINE REHMAN 25 mg, tablets
IMIPROL 25 mg, tablets
IMIPROL 75 mg, tablets
IMIRA 25 mg, tablets
TOFRANIL 25 mg, tablets
Spain: ▲
TOFRANIL 10 mg, 60 dragees
TOFRANIL 25 mg, 50 dragees
TOFRANIL 50 mg, 30 dragees
TOFRANIL PAMOATO 75 mg, 28 capsules
TOFRANIL PAMOATO 150 mg, 28 capsules
Turkey: ▲
TOFRANIL 10 mg, dragees
TOFRANIL 25 mg, dragees
United Kingdom: ▲
IMIPRAMINE AAH PHARMA 10 mg, tablets
IMIPRAMINE AAH PHARMA 25 mg, tablets
IMIPRAMINE AAH PHARMA 5 mg/ml, oral solution
IMIPRAMINE ACTAVIS 10 mg, tablets
IMIPRAMINE ACTAVIS 25 mg, tablets
IMIPRAMINE ALLIANCE HEALTHCARE 10 mg, tablets
IMIPRAMINE ALLIANCE HEALTHCARE 25 mg, tablets
IMIPRAMINE ALLIANCE HEALTHCARE 5 mg/ml, oral solution
IMIPRAMINE ALMUS PHARMA 10 mg, tablets
IMIPRAMINE ALMUS PHARMA 25 mg, tablets
IMIPRAMINE KENT PHARMA 10 mg, tablets
IMIPRAMINE KENT PHARMA 25 mg, tablets
IMIPRAMINE ROSEMONT PHARMA 5 mg/ml, oral solution
U.S.A. and Puerto Rico: ▲
IMIPRAMINE LUPIN 10 mg, 100 tablets
IMIPRAMINE LUPIN 25 mg, 100 tablets
IMIPRAMINE LUPIN 50 mg, 100 tablets
IMIPRAMINE PAR PHARMA 10 mg, 100 tablets
IMIPRAMINE PAR PHARMA 25 mg, 100 tablets
IMIPRAMINE PAR PHARMA 50 mg, 100 tablets
IMIPRAMINE BRYANT RANCH PREPACK 50 mg, 28-100 tablets
IMIPRAMINE MUTUAL PHARMA 10 mg, 30 & 100 tablets
IMIPRAMINE MUTUAL PHARMA 25 mg, 30 & 100 tablets
IMIPRAMINE MUTUAL PHARMA 50 mg, 30 & 100 tablets
IMIPRAMINE REMEDYREPACK 25 mg, 30 tablets
IMIPRAMINE SANDOZ 10 mg, 30 & 100 tablets
IMIPRAMINE SANDOZ 25 mg, 30 & 100 tablets
IMIPRAMINE SANDOZ 50 mg, 30 & 100 tablets
IMIPRAMINE PAMOATE LUPIN 75 mg, 30 & 100 capsules
IMIPRAMINE PAMOATE LUPIN 100 mg, 30 & 100 capsules
IMIPRAMINE PAMOATE LUPIN 125 mg, 30 & 100 capsules
IMIPRAMINE PAMOATE LUPIN 150 mg, 30 & 100 capsules
IMIPRAMINE PAMOATE MALLINCKRODT 75 mg, 30 capsules
IMIPRAMINE PAMOATE MALLINCKRODT 100 mg, 30 capsules
IMIPRAMINE PAMOATE MALLINCKRODT 125 mg, 30 capsules
IMIPRAMINE PAMOATE MALLINCKRODT 150 mg, 30 capsules
IMIPRAMINE PAMOATE ROXANE 75 mg, 30 capsules
IMIPRAMINE PAMOATE ROXANE 100 mg, 30 capsules
IMIPRAMINE PAMOATE ROXANE 125 mg, 30 capsules
IMIPRAMINE PAMOATE ROXANE 150 mg, 30 capsules
TOFRANIL 10 mg, 30 & 100 tablets
TOFRANIL 25 mg, 30 & 100 tablets
TOFRANIL 50 mg, 30 & 100 tablets
TOFRANIL 25 mg/2 ml, injectable solution
TOFRANIL-PM 75 mg, 30 capsules
TOFRANIL-PM 100 mg, 30 capsules
TOFRANIL-PM 125 mg, 30 capsules
TOFRANIL-PM 150 mg, 30 capsules
Page updated: December 10, 2010.