Do not use esomeprazole
If you are allergic (hypersensitive) to the active substance esomeprazole, other medicines in the same group (proton-pump inhibitor, PPI) or any of the other ingredients of the medicinal product prescribed to you. If you think you may be allergic, ask your doctor.
Allergy symptoms may include:
- Asthma attacks with shortness of breath, audible wheezing or rapid breathing.
- More or less sudden swelling of the face, lips, tongue or elsewhere in the body. It is especially critical if it affects the vocal cords.
- Hives, itching, rash
- Anaphylactic shock (loss of consciousness, paleness, sweating, etc.).
Nor take this medicine if:
If you are being treated with atazanavir (a medicine for the treatment of patients infected with HIV-1 virus).
Take special care with esomeprazole
- If you have severe liver problems. In this case, you should consult your doctor, as he may reduce your dose.
- If you have severe kidney problems. In this case, you should consult your doctor.
If you have been prescribed triple therapy for the eradication of Helicobacter pylori or you receive esomeprazole for taking it when you need, tell your doctor about any other medications with which you are being treated.
If your doctor has told you to take the tablets only when needed and your symptoms change, you must inform him.
Consult your doctor if you have suffered previously any of the above circumstances.
Taking other medicines
Tell your doctor or pharmacist if you are taking or have recently taken any other medicines, including herbal products or drugs obtained without a prescription.
Especially if you are taking esomeprazole while any of the following medications:
- Itraconazole, ketoconazole or voriconazole (for fungal infections),
- Diazepam (for anxiety and/or insomnia),
- Phenytoin (for epilepsy),
- Citalopram, imipramine, clomipramine (for depression),
- Warfarin or other coumarin derivatives (for blood clotting),
- Cisapride (to accelerate gastric emptying) or
- Atazanavir (for treatment of patients infected with HIV-1 virus)
you should consult your doctor immediately because taking esomeprazole with any of them can modify its effect.
Consult your doctor or pharmacist before taking any medicine.
Remember that your doctor has prescribed this medicine only for you. Never give it to someone else.
Use with food and beverages
If you have difficulty swallowing, the tablets may be dispersed in half a glass of still water. Do not use other liquids.
Granulated gastro-resistant can be taken with or without food.
Consult your doctor or pharmacist before taking any medicine.
Special physiological situations
Always consult your doctor or pharmacist before taking any medicine during pregnancy or lactation.
Pregnancy
Before taking this medication, tell your doctor if you are pregnant or trying to become pregnant. If you are pregnant, take only esomeprazole if your doctor prescribes it.
Lactation
Before taking this medication, tell your doctor if you are breast-feeding. Do not use esomeprazole if you are breast-feeding unless your doctor tells you.
Children
Do not give this medicine to children younger than 1 year or weighing less than 10 kg (<10 kg).
Driving and using machines
There is no evidence of effects on the ability to drive or operate machinery.
Consult your doctor or pharmacist before taking any medicine.
Follow carefully the instructions of use of esomeprazole provided by your doctor. Consult your doctor or pharmacist when in doubt. Follow the instructions of the physician in preference to those given in this website, which may be different. Ask your doctor to explain any aspect that you do not understand, contained in the instruction leaflet that comes with the medicine.
Method of using and route of administration
Your doctor will indicate you how much medicine to take and when to take it. You can take the tablets or granules with food or on an empty stomach.
The tablets should not be chewed or crushed. Should be swallowed whole with half a glass of liquid.
For patients with difficulty swallowing, tablets can also be dispersed in half a glass of still water. Do not use other liquids. Stir until the tablets disintegrate (observe that is not formed a clear solution ). You can drink it immediately or within 30 minutes. Always stir the liquid dispersion just before drinking.
To ensure that you have taken all the medication, rinse the glass filling it halfway with water and drink it again. The solid particles contain the medication. The granules should not be chewed or crushed.
For patients who can not swallow, the tablets can be dispersed in non-carbonated water and administered through a gastric tube. It is important to carefully check the suitability of the syringe and the selected probe.
Dosage, frequency of administration and duration of treatment:
Adults and adolescents from 12 years of age
Treatment of gastroesophageal reflux disease (GERD)
The usual dose is one or two tablets of 20 mg or 40 mg esomeprazole once daily or its equivalent in granules. The duration of treatment is generally up to 4 weeks.
Your doctor may choose that you keep taking the tablets, depending on how you respond to treatment. Once completed, your doctor may tell you to continue taking a maintenance dose of esomeprazole once daily or only when needed.
Adults
Treatment for duodenal ulcer (elimination of Helicobacter pylori) and preventing relapses of ulcers (associated with Helicobacter pylori) in combination with an appropriate antibacterial therapeutic regimen:
The usual dose is 20 mg esomeprazole twice daily. Your doctor will also tell you to take the following antibiotics: amoxicillin and clarithromycin. The usual duration of treatment is one week.
Follow carefully the instructions for taking the medication and ask your doctor if you are unsure.
Therapy for the healing of gastric ulcers and prevention of gastric and duodenal ulcers associated with NSAIDs treatment:
The usual dose is 20 mg esomeprazole once daily. The duration of treatment for healing of gastric ulcers is 4 to 8 weeks.
Treatment of Zollinger-Ellison syndrome:
The usual starting dose for adults is 40 mg esomeprazole twice daily. Your doctor will adjust the dose according to your needs and also will decide how long to take this medicine.
Children
Esomeprazole should not be administered to children younger than 1 year or weighing less than 10 kg (<10 kg).
Children between 1 and 11 years old can take this medicine. The usual dose is one sachet (10 mg) or two sachets (20 mg) once daily. The dose for children is based on body weight and the doctor will decide the correct dose.
Administration of solution for injection or infusion:
This drug is administered intravenously by a health professional.
Patients who can not take oral medication may be treated intravenously with 20-40 mg esomeprazole once daily.
Patients with reflux oesophagitis should be treated with 40 mg of esomeprazole (1 vial), once a day.
Patients with reflux disease treated symptomatically should be treated with 20 mg of esomeprazole (half a vial), once a day.
For healing of gastric ulcers associated with NSAIDs treatment, the usual dose is 20 mg of esomeprazole (half a vial), once a day
For the prevention of gastric and duodenal ulcers associated with treatment with NSAIDs, risk patients should be treated with 20 mg of esomeprazole (half a vial), once a day.
Usually, the duration of intravenous therapy is short and change to oral treatment should be performed as soon as possible.
This drug can be administered by injection or intravenous infusion after reconstitution of the solution from the powder contained in the vial.
Injection
40 mg dose: The reconstituted solution should be administered as an intravenous injection
for a period of at least 3 minutes.
20 mg dose: Administer half of the reconstituted solution as an intravenous injection over a period of about 3 minutes. Dispose of all unused solution.
Perfusion
40 mg dose: The reconstituted solution should be administered as an intravenous infusion for a period of 10 to 30 minutes.
20 mg dose: Administer half of the reconstituted solution as an infusion intravenously over a period of 10-30 minutes. Dispose of all unused solution.
If you think that the effect of the medicine is too strong or too weak, consult your doctor.
If you have any further questions on the use of this product, ask your doctor or pharmacist.
Like all medicines, esomeprazole can cause side effects, although not everybody gets them.
The frequency of side effects is classified into:
Very common: affect 1 out of 1-10 patients
Common: affect 1 out of 10-100 patients
Uncommon: affect 1 out of 100-1.000 patients
Rare: affect 1 out of 1.000-10.000 patients
Very Rare: affect less than 1 in 10,000 patients
Incidence not known: Can not be established the true incidence from the available data
Tell your doctor if you notice any of the adverse reactions described in this website or in the leaflet accompanying the package.
The adverse effects are classified according to its frequency:
Common (affect 1 in 10-100 patients), uncommon (affect 1 in 100-1000 patients), rare (affect 1 in 1.000-10.000 patients) and very rare (affect less than 1 in 10.000 patients).
Common side effects:
- Nervous system disorders: headaches
- Gastrointestinal disorders: abdominal pain, constipation, diarrhea,
flatulence, nausea/vomiting.
Uncommon side effects:
- Metabolism and nutrition disorders: Limb edema (swelling by fluid accumulation)
- Psychiatric disorders: Insomnia,
- Nervous system disorders: dizziness, feeling hot, tingling or numbness, drowsiness,
- Disorders of the ear and labyrinth: Vertigo,
- Gastrointestinal disorders: Dry mouth
- Hepatobiliary disorders: Increased liver enzymes
- Disorders of the skin and subcutaneous tissue: Dermatitis, itching, rash, urticaria.
Rare side effects:
- Disorders of the blood and lymphatic system: Leukopenia (low white blood cell), thrombocytopenia (decreased number of platelets)
- Immune system disorders: Hypersensitivity reactions (allergic reactions), eg, fever, swelling of face, lips, tongue and/or throat(angioedema) and anaphylactic reaction/shock,
- Metabolism and nutrition disorders: Low sodium levels
- Psychiatric disorders: Agitation, confusion, depression,
- Nervous system disorders: Altered taste,
- Eye disorders: blurred vision
- Respiratory, thoracic and mediastinal disorders: bronchospasm
- Gastrointestinal disorders: oral inflammation, gastrointestinal fungal infections
- Hepatobiliary disorders: Hepatitis which may be accompanied by jaundice (yellowing of the skin and whites of the eyes),
- Disorders of the skin and subcutaneous tissue: Hair loss, sensitivity to light
- Musculoskeletal, connective tissue, and bone disorders: Joint pain, muscle pain
- General disorders and in administration site: discomfort, increased sweating.
Very rare side effects:
- Disorders of the blood and lymphatic system: Agranulocytosis (decrease of granulocytes, leukocytes with a defensive function),
pancytopenia (global decline in the number of cells in blood)
- Psychiatric disorders: aggressiveness, hallucinations,
- Hepatobiliary disorders: Liver failure, disorientation, confusion, decreased consciousness in patients with pre-existing liver disease,
- Disorders of the skin and subcutaneous tissue: Severe skin reactions
(erythema multiforme, toxic epidermal necrolysis),
- Musculoskeletal, connective tissue, and bone disorders: muscle weakness,
- Renal and urinary disorders: Interstitial nephritis (kidney disorder)
- Reproductive system and breast disorders: Enlarged breasts (gynecomastia).
If you notice any side effects not listed in this website or in the leaflet accompanying the package, ask your doctor or pharmacist.
If any of the side effects gets serious, tell your doctor or pharmacist.
This page contains a list of brands of authorized pharmaceutical specialties of the active principle esomeprazole in the countries listed below:
[ Australia] [ Brazil] [ Canada] [ France] [ Germany] [ India] [ Italy] [ Japan] [ Korea] [ Mexico] [ Puerto Rico] [ Spain] [ Turkey] [ United Kingdom] [ U.S.A]
Given the nature of the pharmaceutical market, some specialties may be unavailable, have been removed from the pharmaceutical market or have changed its name. So that, in no case can take decisions based on the information contained in the page. MEDIZZINE is not responsible for any damage arising from the information provided, which may be incomplete or outdated.
Warning:
With exceptions expressly indicated, these lists do not include active principle associations with other drugs or clinical use containers.
Australia: ▲
NEXIUM 20 mg, 30 tablets
NEXIUM 40 mg, 30 tablets
Brazil: ▲
NEXIUM 20 mg, 7, 14 and 28 tablets
NEXIUM 40 mg, 7, 14 and 28 tablets
NEXIUM IV 40 mg, vials of lyophilized powder for IV solution
Canada: ▲
APO-ESOMEPRAZOLE 20 mg, 28 and 100 tablets
APO-ESOMEPRAZOLE 40 mg, 28 and 100 tablets
ESOMEPRAZOLE PRO DOC 20 mg, 28 and 100 tablets
ESOMEPRAZOLE PRO DOC 40 mg, 28 and 100 tablets
MYLAN-ESOMEPRAZOLE 20 mg, 100 tablets
MYLAN-ESOMEPRAZOLE 40 mg, 100 tablets
NEXIUM 10 mg, 30 sachets with granules for oral suspension
NEXIUM 20 mg, 30 tablets
NEXIUM 40 mg, 30, 60 and 100 tablets
France: ▲
INEXIUM 10 mg, 28 sachets with granules for oral suspension
INEXIUM 20 mg, 7 tablets
INEXIUM 40 mg, 14 tablets
INEXIUM 40 mg, lyophilized powder for IV solution
Germany: ▲
ESOMEPRAZOL ABZ 20 mg, 15, 30, 60 and 90 tablets
ESOMEPRAZOL ABZ 40 mg, 15, 30, 60 and 90 tablets
ESOMEPRAZOL TAD 20 mg, 15, 30, 60 and 90 tablets
ESOMEPRAZOL TAD 20 mg, 15, 30, 60 and 90 tablets
ESOMEPRAZOL RATIOPHARM 20 mg, 15, 30, 60 and 90 tablets
ESOMEPRAZOL RATIOPHARM 40 mg, 15, 30, 60 and 90 tablets
NEXIUM MUPS 20 mg, 15, 30, 60 and 90 tablets
NEXIUM MUPS 20 mg, 15, 30, 60 and 90 tablets
India: ▲
available associated with domperidone
Italy: ▲
ARILIAR 20 mg, 14 capsules
ARILIAR 40 mg, 14 capsules
AXAGON 20 mg, 14 tablets
AXAGON 40 mg, 14 tablets
AXAGON 40 mg, lyophilized powder for IV solution
ESOMEPRAZOLO DOC 20 mg, 14 tablets
ESOMEPRAZOLO DOC 40 mg, 14 tablets
ESOMEPRAZOLO EG 20 mg, 14 capsules
ESOMEPRAZOLO EG 40 mg, 14 capsules
ESOMEPRAZOLO RANBAXY 20 mg, 14 tablets
ESOMEPRAZOLO RANBAXY 40 mg, 14 tablets
ESOMEPRAZOLO MYLAN 20 mg, 14 capsules
ESOMEPRAZOLO MYLAN 40 mg, 14 capsules
ESOMEPRAZOLO SANDOZ 20 mg, 14 capsules
ESOMEPRAZOLO SANDOZ 40 mg, 14 capsules
ESOMEPRAZOLO TEVA 20 mg, 14 capsules
ESOMEPRAZOLO TEVA 40 mg, 14 capsules
ESOMEPRAZOLO ZENTIVA 20 mg, 14 capsules
ESOMEPRAZOLO ZENTIVA 40 mg, 14 capsules
ESOPRAL 20 mg, 14 tablets
ESOPRAL 40 mg, 14 tablets
ESOPRAL 40 mg, lyophilized powder for IV solution
LUCEN 20 mg, 14 tablets
LUCEN 40 mg, 14 tablets
LUCEN 40 mg, lyophilized powder for IV solution
LUCEN 10 mg, 28 sachets with granules for oral suspension
NEXIUM 20 mg, 14 tablets
NEXIUM 40 mg, 14 tablets
NEXIUM 40 mg, lyophilized powder for IV solution
NEXIUM 10 mg, 28 sachets with granules for oral suspension
Japan: ▲
Information not available
Korea: ▲
NEXIUM 20 mg, tablets
NEXIUM 40 mg, tablets
Mexico: ▲
NEXIUM MUPS 20 mg, 14 tablets
NEXIUM MUPS 40 mg, 7 and 14 tablets
NEXIUM 2.5 mg, 7, 14 and 28 sachets
NEXIUM 5 mg, 7, 14 and 28 sachets
NEXIUM 10 mg, 7, 14 and 28 sachets
NEXIUM 20 mg, 7, 14 and 28 sachets
NEXIUM 40 mg, 7, 14 and 28 sachets
NEXIUM IV 40 mg, 1 vial for injectable solution
Spain: ▲
AXIAGO 20 mg, 14, 28 and 56 tablets
AXIAGO 40 mg, 14 and 28 tablets
AXIAGO 10 mg granules for oral suspension, 28 sachets
NEXIUM MUPS 20 mg, 14, 28 and 56 tablets
NEXIUM MUPS 40 mg, 14 and 28 tablets
NEXIUM 10 mg granules for oral suspension, 28 sachets
NEXIUM 40 mg, lyophilized powder, 1 and 10 vials
Turkey: ▲
ESMARA 20 mg, 28 tablets
ESMARA 40 mg, 28 tablets
NEXIUM 10 mg, 28 sachets with granules for oral suspension
NEXIUM 20 mg, 14 and 28 tablets
NEXIUM 40 mg, 14 and 28 tablets
NEXIUM 40 mg, lyophilized powder for IV solution
NEXOMEP 20 mg, 28 tablets
NEXOMEP 40 mg, 28 tablets
NEXSTEP 20 mg, 28 tablets
NEXSTEP 40 mg, 28 tablets
United Kingdom: ▲
ESOMEPRAZOLE AAH PHARMA 20 mg, 28 capsules
ESOMEPRAZOLE AAH PHARMA 20 mg, 28 tablets
ESOMEPRAZOLE AAH PHARMA 40 mg, 28 capsules
ESOMEPRAZOLE AAH PHARMA 40 mg, 28 tablets
ESOMEPRAZOLE AAH PHARMA 40 mg, lyophilized powder for IV solution
ESOMEPRAZOLE ACTAVIS 20 mg, 28 tablets
ESOMEPRAZOLE ACTAVIS 40 mg, 28 tablets
ESOMEPRAZOLE ALLIANCE 20 mg, 28 tablets
ESOMEPRAZOLE ALLIANCE 40 mg, 28 tablets
ESOMEPRAZOLE GENERICS 20 mg, 28 capsules
ESOMEPRAZOLE GENERICS 40 mg, 28 capsules
ESOMEPRAZOLE TEVA 20 mg, 28 tablets
ESOMEPRAZOLE TEVA 40 mg, 28 tablets
ESOMEPRAZOLE SUN PHARMA 40 mg, lyophilized powder for IV solution
ESOMEPRAZOLE ZENTIVA 20 mg, 28 tablets
ESOMEPRAZOLE ZENTIVA 40 mg, 28 tablets
NEXIUM 10 mg, 28 sachets with granules for oral suspension
NEXIUM 20 mg, 28 tablets
NEXIUM 40 mg, 28 tablets
NEXIUM 40 mg, lyophilized powder for IV solution
U.S.A. and Puerto Rico: ▲
NEXIUM 20 mg, 15, 28, 30, 60 and 90 extended release capsules
NEXIUM 40 mg, 10, 30, 60 and 90 extended release capsules
NEXIUM 10 mg, 30 sachets with extended release granules
NEXIUM 4 mg/ml, 10 vials with 5 ml of injectable solution
NEXIUM 8 mg/ml, 10 vials with 5 ml of injectable solution
Date page update: December 17, 2010.