Ropinirole belongs to a group of medicines called dopamine agonists. Dopamine agonists act the same way as a natural substance found in the brain called dopamine.
Ropinirole is used to treat idiopathic restless legs syndrome moderate to severe. A moderate or severe restless legs syndrome includes patients who have difficulty sleeping or severe discomfort in the legs or arms.
Restless legs syndrome is a condition characterized by an irresistible urge to move the legs and, occasionally, the arms, usually accompanied by uncomfortable sensations such as tingling, burning or prickling. These symptoms occur during periods of rest or inactivity such as sitting or lying down, especially in bed and worsen in the afternoon and evening. Usually, the only relief is obtained by walking about or moving the affected limbs, which often leads to problems sleeping.
Ropinirole relieves the discomfort and reduces the urge to move the limbs that disrupt nighttime sleep.
The tablet formulation of sustained release is used to treat Parkinson's disease.
Patients suffering Parkinson's disease have low levels of dopamine in certain parts of the brain. Ropinirole has a similar effect to natural dopamine and thus, reduces the symptoms of Parkinson's disease.
Medizzine recommends consulting your doctor if you are unsure (or you do not know) why you have been given ropinirole.
Other ingredients of available commercial presentations:
In addition to the active ingredient, ropinirole hydrochloride, this medicine contains lactose monohydrate, microcrystalline cellulose, croscarmellose
sodium, magnesium stearate, hypromellose, macrogol 400, titanium dioxide, yellow iron oxide, red iron oxide, and indigo (indigo carmine).
The prolonged release tablets contain, besides ropinirole hydrochloride, hypromellose, hydrogenated castor oil, carmellose sodium, povidone, maltodextrin, magnesium stearate, lactose monohydrate, colloidal anhydrous silica, mannitol, ropinirole oxide yellow iron, glycerol di behenate, pink OPADRY OY-S-24900 (hypromellose, iron oxide yellow, titanium dioxide, macrogol 400, iron oxide red).
Warning:
The composition of the various presentations may vary from one country to another. We recommend you consult the information provided by your local supplier.
Do not use ropinirole
If you are allergic (hypersensitive) to ropinirole or any of the other ingredients of the medicinal product prescribed to you. If you think may be allergic, ask your doctor.
Allergy symptoms may include:
- Asthma attacks with shortness of breath, audible wheezing or rapid breathing.
- More or less sudden swelling of the face, lips, tongue or elsewhere in the body. It is especially critical if it affects the vocal cords.
- Hives, itching, rash
- Anaphylactic shock (loss of consciousness, paleness, sweating, etc.).
Nor you should take this medicine:
- If you have a severe liver disease
- If you have a severe kidney disease
Take special care with ropinirole
Tell your doctor before you start taking this medicine:
- If you are pregnant or think you are pregnant
- If you are breastfeeding
- If you have an intolerance to some sugars (eg lactose)
- If you have a liver disease
- If you have any heart ailment
- If you have a serious mental disorder
- If you've had impulses and/or unusual behaviors (such as gambling or excessive sexual behavior). Tell your doctor if you or someone in your family notice that you are having unusual behaviors (as unusual urges or impulses to gambling and/or increased sexual behavior) during treatment with ropinirole. Your doctor may adjust the dose or interrupt ropinirole treatment.
During treatment with ropinirole should take special care when driving or using machinery. If you experience excessive sleepiness or fall asleep suddenly without apparently feeling sleepy, do not drive or use machinery, and contact your doctor.
If during treatment, your symptoms become worse, begin earlier in the day or after less time at rest, or affect other parts of your body such as arms, consult your doctor who may adjust the ropinirole dose you are taking.
Remember that your doctor has prescribed this medicine only for you. Never give it to someone else.
If in doubt, consult your doctor.
Taking other medicines
Tell your doctor or pharmacist if you are taking or have recently taken any other medicines, including herbal products or drugs obtained without a prescription.
The effect of ropinirole may be increased or decreased by other medicines and vice versa. These drugs include:
- Ciprofloxacin
- Enoxacin
- Fluvoxamine
- Theophylline
- Hormone Replacement Therapy
- Antipsychotics and other drugs that block dopamine in the brain, such as sulpiride or metoclopramide.
Tell your doctor if:
- You are already receiving treatment for Restless Legs Syndrome.
- If you are quitting or starting smoking while taking ropinirole. Your doctor may need to adjust your dose.
- If you are taking ropinirole and your doctor will prescribe any other medicine.
Use with food and beverages
Taking Ropinirole with food may reduce the likelihood of being dizzy.
Consult your doctor or pharmacist before taking any medicine.
Special physiological situations
Pregnancy and lactation
always consult your doctor or pharmacist before taking any medicine during pregnancy or lactation.
The use of ropinirole is not recommended during pregnancy. This medicine should only be used during pregnancy if your doctor considers that the benefit to you is greater than any possible risk to the fetus.
Tell your doctor immediately if you are pregnant, if you think you are pregnant or planning to become pregnant. Your doctor will advise you to discontinue treatment.
Ropinirole should not be used during breast-feeding as milk production may be affected. Tell your doctor immediately if you are breastfeeding or plan to breastfeed. Your doctor will advise you to discontinue treatment.
Use in children
Not studied the use of ropinirole in children with restless legs syndrome, so this drug is not usually prescribed for patients under 18.
Driving and using machines
This medicine does not usually affect the daily activities of patients. However, it can cause extreme sleepiness (somnolence) and sudden sleep onset episodes. If you experience any of these effects, you must refrain from driving or engaging in activities in which, if you suffer sudden sleepiness or falling asleep, may be a risk of serious injury or death (for example using machinery) until these episodes are resolved.
Like all medicines, ropinirole can cause side effects although not everybody gets them.
The frequency of side effects is classified into:
Very common: affect 1 out of 1-10 patients
Common: affect 1 out of 10-100 patients
Uncommon: affect 1 out of 100-1.000 patients
Rare: affect 1 out of 1.000-10.000 patients
Very Rare: affect less than 1 in 10,000 patients
Incidence not known: Can not be established the true incidence from the available data
Tell your doctor if you notice any side effects that worry you. The most common ropinirole adverse reactions may occur early in treatment and/or when increasing the dose. They are generally mild and may decrease after you have taken the medicine for a while.
Common and very common side effects:
- Feeling sick
- Dizziness (or vertigo)
- Drowsiness
- Fatigue (mental or physical tiredness)
- Stomach pain
- Lightheadedness
- Nervousness
Uncommon side effects:
- Confusion and Hallucinations.
- Reduction in blood pressure, which can cause that you feel dizzy or faint, especially when standing up from a sitting or lying.
During treatment with this medicine, you may experience an unusual worsening of symptoms, (eg symptoms become worse, start earlier in the day or after less time at rest, or affect other body parts like arms). If this happens, consult your doctor.
Consult your doctor if your symptoms worsen after you stop taking ropinirole.
Very rarely, there have been reports of altered liver function (increased enzyme levels).
This medicine may cause an extreme daytime sleepiness (excessive drowsiness) and very
rarely sudden onset of sleep, in which patients suddenly fall asleep without apparently feeling sleepy.
Have been reported other psychotic reactions in addition to hallucinations, such as confusion severe (delusions), irrational ideas (misconceptions) and irrational suspicion (paranoia).
Some patients taking ropinirole may have different behavior than usual, for example, unusual urge to gambling and/or increased sexual behaviors.
This list does not include all adverse reactions associated with the use of ropinirole, both well established as those that are under consideration or confirmation. In case you feel unwell, should immediately consult with the doctor who prescribed this medicine.
If you notice any side effects not listed in this website or in the leaflet accompanying the package, ask your doctor or pharmacist.
If any of the side effects gets serious, tell your doctor or pharmacist.
This page contains list of brands of authorized pharmaceutical specialties of the active principle ropinirole in the countries listed below:
[ Australia] [ Brazil] [ Canada] [ France] [ Germany] [ India] [ Italy] [ Japan] [ Mexico] [ Pakistan] [ Puerto Rico] [ Spain] [ Turkey] [ United Kingdom] [ U.S.A]
Given the nature of the pharmaceutical market, some specialties may be unavailable, have been removed from pharmaceutical market or have changed its name. So that, in no case can take decisions based on the information contained in the page. MEDIZZINE is not responsible for any damage arising from the information provided, which may be incomplete or outdated.
Warning:
With exceptions expressly indicated, these lists do not include active principle associations with other drugs or clinical use containers.
Australia: ▲
APPESE 0.5 mg, 28 tablets
APPESE 2 mg, 28 tablets
REPREVE 0.25 mg, 12 tablets
REPREVE 0.5 mg, 28 tablets
REPREVE 2 mg, 28 tablets
ROPACCORD 0.5 mg, 28-84 tablets
ROPACCORD 2 mg, 28-84 tablets
ROPINIROLE-GA 0.5 mg, 28 tablets
ROPINIROLE-GA 2 mg, 28 tablets
Brazil: ▲
REQUIP 0.25 mg, 21 tablets
REQUIP 1 mg, 21 tablets
REQUIP 2 mg, 21 tablets
REQUIP 5 mg, 21 tablets
Canada: ▲
ACT ROPINIROLE 0.25 mg, tablets
ACT ROPINIROLE 1 mg, tablets
ACT ROPINIROLE 2 mg, tablets
ACT ROPINIROLE 5 mg, tablets
JAMP-ROPINIROLE 0.25 mg, tablets
JAMP-ROPINIROLE 1 mg, tablets
JAMP-ROPINIROLE 2 mg, tablets
JAMP-ROPINIROLE 5 mg, tablets
PMS-ROPINIROLE 0.25 mg, tablets
PMS-ROPINIROLE 1 mg, tablets
PMS-ROPINIROLE 2 mg, tablets
PMS-ROPINIROLE 5 mg, tablets
RAN-ROPINIROLE 0.25 mg, tablets
RAN-ROPINIROLE 1 mg, tablets
RAN-ROPINIROLE 2 mg, tablets
RAN-ROPINIROLE 5 mg, tablets
REQUIP 0.25 mg, tablets
REQUIP 1 mg, tablets
REQUIP 2 mg, tablets
REQUIP 5 mg, tablets
ROPINIROLE SANIS HEALTH 0.25 mg, tablets
ROPINIROLE SANIS HEALTH 1 mg, tablets
ROPINIROLE SANIS HEALTH 5 mg, tablets
France: ▲
ADARTREL 0,25 mg, tablets
ADARTREL 0,50 mg, tablets
ADARTREL 2 mg, tablets
REQUIP 0,25 mg, tablets
REQUIP 0,50 mg, tablets
REQUIP 1 mg, tablets
REQUIP 2 mg, tablets
REQUIP 5 mg, tablets
REQUIP LP 2 mg, extended release tablets
REQUIP LP 4 mg, extended release tablets
REQUIP LP 8 mg, extended release tablets
ROPINIROLE ACCORD 0,25 mg, tablets
ROPINIROLE ACCORD 0,50 mg, tablets
ROPINIROLE ACCORD 1 mg, tablets
ROPINIROLE ACCORD 2 mg, tablets
IROPINIROLE ACCORD 5 mg, tablets
ROPINIROLE ARROW 0,25 mg, tablets
ROPINIROLE ARROW 0,50 mg, tablets
ROPINIROLE ARROW 1 mg, tablets
ROPINIROLE ARROW 2 mg, tablets
ROPINIROLE KRKA LP 2 mg, extended release tablets
ROPINIROLE KRKA LP 4 mg, extended release tablets
ROPINIROLE KRKA LP 8 mg, extended release tablets
ROPINIROLE MYLAN 0,25 mg, tablets
ROPINIROLE MYLAN 0,50 mg, tablets
ROPINIROLE MYLAN 1 mg, tablets
ROPINIROLE MYLAN 2 mg, tablets
ROPINIROLE MYLAN 5 mg, tablets
ROPINIROLE QUALIMED 0,25 mg, tablets
ROPINIROLE QUALIMED 0,5 mg, tablets
ROPINIROLE QUALIMED 1 mg, tablets
ROPINIROLE SANDOZ 0,50 mg, tablets
ROPINIROLE SANDOZ 1 mg, tablets
ROPINIROLE SANDOZ 2 mg, tablets
ROPINIROLE SANDOZ 5 mg, tablets
ROPINIROLE SANDOZ LP 2 mg, extended release tablets
ROPINIROLE SANDOZ LP 4 mg, extended release tablets
ROPINIROLE SANDOZ LP 8 mg, extended release tablets
ROPINIROLE TEVA 0,25 mg, tablets
ROPINIROLE TEVA 0,50 mg, tablets
ROPINIROLE TEVA 1 mg, tablets
ROPINIROLE TEVA 2 mg, tablets
ROPINIROLE TEVA 5 mg, tablets
ROPINIROLE TEVA LP 2 mg, extended release tablets
ROPINIROLE TEVA LP 4 mg, extended release tablets
ROPINIROLE TEVA LP 8 mg, extended release tablets
ROPINIROLE ZENTIVA LP 2 mg, extended release tablets
ROPINIROLE ZENTIVA LP 4 mg, extended release tablets
ROPINIROLE ZENTIVA LP 8 mg,, extended release tablets
Germany: ▲
ADARTREL 0.25-2 mg, tablets
LEPINOLE 2-4-8 mg, extended release tablets
RALNEA 2-4-8 mg, extended release tablets
REQUIP 0.25-5 mg, tablets
REQUIP LP 2-4-8 mg, extended release tablets
REQUIP-MODUTAB 2-4 mg, extended release tablets
ROPINAL 0.25-5 mg, tablets
ROPINIROL - 1 A PHARMA 0.25-8 mg, tablets
ROPINIROL ABZ 0.25-8 mg, tablets
ROPINIROL ACIS 0.25-5 mg, tablets
ROPINIROL AL 0,25-4 mg, tablets
ROPINIROL AL 2-3-4-8 mg, extended release tablets
ROPINIROL AUROBINDO 2-4-8 mg, extended release tablets
ROPINIROL DURA 0.25-5 mg, tablets
ROPINIROL GLENMARK 0,25-5 mg, tablets
ROPINIROL HEUMANN 0,25-5 mg, tablets
ROPINIROL HEUMANN 2-4-8 mg, extended release tablets
ROPINIROL HEXAL 0,25-5 mg, tablets
ROPINIROL HEXAL 2-4-8 mg, extended release tablets
ROPINIROL STADA 0,25-4 mg, tablets
ROPINIROL STADA 2-4-8 mg, extended release tablets
ROPINIROL TAD 0,5-1-2 mg, tablets
ROPINIROL WINTHROP 0,25-5 mg, tablets
ROPINIROL-ACTAVIS 2-4-8 mg, extended release tablets
ROPINIROL-BIOMO 0,25-5 mg, tablets
ROPINIROL-CT 0,25-2 mg, tablets
ROPINIROL-CT 2-4-8 mg, extended release tablets
ROPINIROL-HORMOSAN 2-4-8 mg, extended release tablets
ROPINIROL-NEURAXPHARM 0,25-5 mg, tablets
ROPINIROL- NEURAXPHARM 2-4-8 mg, extended release tablets
ROPINIROL-RATIOPHARM 0,25-4 mg, tablets
ROPINIROL- RATIOPHARM 2-4-8 mg, extended release tablets
India: ▲
PARKIROP 0.5 mg, tablets
PARKIROP 1 mg, tablets
PARKIROP 2 mg, tablets
ROPARK 0.25 mg, tablets
ROPARK 0.50 mg, tablets
ROPARK 1 mg, tablets
ROPARK 2 mg, tablets
ROPARK-XL 2 mg, extended release tablets
ROPIN 0.25 mg, tablets
ROPIN 0.5 mg, tablets
ROPIN 1 mg, tablets
ROPIN 2 mg, tablets
ROPITOR 0.25 mg, tablets
ROPITOR 0.5 mg, tablets
ROPITOR 1 mg, tablets
ROPITOR 2 mg, tablets
Italy: ▲
REQUIP 0,25-5 mg, tablets
REQUIP 2-4-8 mg, extended release tablets
ROPINIROLO ACCORD 1 mg, tablets
ROPINIROLO DOC GENERICI LP 2-4-8 mg, extended release tablets
ROPINIROLO EG 0.25-5 mg, tablets
ROPINIROLO EG LP 2-4-8 mg, extended release tablets
ROPINIROLO KRKA 2-4-8 mg, extended release tablets
ROPINIROLO MYLAN 0,25-5 mg, tablets
ROPINIROLO SANDOZ LP 2-4-8 mg, extended release tablets
ROPINIROLO TEVA LP 2-4-8 mg, extended release tablets
Japan: ▲
REQUIP 0.25-1-2 mg, tablets
REQUIP CR 2-8 mg, extended release tablets
Mexico: ▲
REQUIP IR 0.25 mg, 2, 12 and 21 tablets
REQUIP IR 0.5 mg, 21, 28 and 84 tablets
REQUIP IR 1 mg, 21 tablets
REQUIP IR 2 mg, 21, 28 and 84 tablets
REQUIP IR 5 mg, 21 tabletas
Pakistan: ▲
GEF 0,25-1-2 mg, tablets
PROPINOL 0,25-1-2 mg, tablets
REOL 0,25-2 mg, tablets
REQUIP 0,25-1-2 mg, tablets
RONIROL 0,25-1-2 mg, tablets
ROPINOL 0,25-1 mg, tablets
ROPIROL 0,25 mg, tablets
ROPIZAM 0,25 mg, tablets
XMG 0,25-1-2 mg, tablets
Spain: ▲
ADARTREL O,25 mg, 12 tablets
ADARTREL 0.50 mg, 84 tablets
ADARTREL 2 mg, 28 tablets
REQUIP 0.25 mg, 126 tablets
REQUIP 0.50 mg, 21 tablets
REQUIP 1 mg, 21 y 84 tablets
REQUIP 2 mg, 84 tablets
REQUIP 5 mg, 84 tablets
REQUIP-PROLIB 2 mg, 28 tablets
REQUIP-PROLIB 4 mg, 28 tablets
REQUIP-PROLIB 8 mg, 28 tablets
ROPIGEN 0,25 mg, 126 tablets
ROPIGEN 0,50 mg, 21 tablets
ROPIGEN 1 mg, 84 tablets
ROPIGEN 2 mg, 84 tablets
ROPIGEN 5 mg, 84 tablets
ROPINIROL CINFA 0,25 mg, 126 tablets
ROPINIROL CINFA 0,50 mg, 21 tablets
ROPINIROL CINFA 1 mg, 84 tablets
ROPINIROL CINFA 2 mg, 84 tablets
ROPINIROL CINFA 5 mg, 84 tablets
ROPINIROL MYLAN 0,25 mg, 126 tablets
ROPINIROL MYLAN 0,50 mg, 21 tablets
ROPINIROL MYLAN 1 mg, 84 tablets
ROPINIROL MYLAN 2 mg, 84 tablets
ROPINIROL MYLAN 5 mg, 84 tablets
ROPINIROL NORMON 0,25 mg, 126 tablets
ROPINIROL NORMON 0,50 mg, 21 y 84 tablets
ROPINIROL NORMON 1 mg, 84 tablets
ROPINIROL NORMON 2 mg, 84 tablets
ROPINIROL NORMON 5 mg, 84 tablets
ROPINIROL STADA 0,25 mg, 84 tablets
ROPINIROL STADA 0,50 mg, 84 tablets
ROPINIROL STADA 1 mg, 84 tablets
ROPINIROL STADA 2 mg, 84 tablets
ROPINIROL STADA 5 mg, 84 tablets
ROPINIROL WINTHROP 1 mg, 84 tablets
ROPINIROL WINTHROP 5 mg, 84 tablets
Turkey: ▲
REQUIP 0,25-5 mg, 21 tablets
REQUIP XL 2-4-8 mg, 28 extended-release tablets
VIDANT XL 2-4-8 mg, 28 extended-release tablets
United Kingdom: ▲
ADARTREL 0,25-0,5-2 mg, tablets
AIMPART XL 2-4-8 mg, 28 modified-release tablets
RALNEA XL 2-4-8 mg, 28 modified-release tablets
RAPONER XL 2-4-8 mg, 28 modified-release tablets
REPINEX XL 2-4-8 mg, 28 modified-release tablets
REQUIP 1-2-5 mg, tablets
REQUIP XL 2-4-8 mg, 28 modified-release tablets
ROPINIROLE AAH PHARMA 0,25-0,5-1-2-5 mg tablets
ROPINIROLE ACTAVIS 0,25-0,5-1-2-5 mg tablets
ROPINIROLE ALLIANCE HEALTHCARE 0,25-0,5-1-2-5 mg, tablets
ROPINIROLE ARROWS 1 mg, tablets
ROPINIROLE GENERICS 1-2-5 mg, tablets
ROPINIROLE TEVA 0,25-0,5-1-2-5 mg, tablets
ROPINIROLE WOCKHARDT 0,25-0,5-1-2-5 mg, tablets
SPIROCO XL 2-4-8 mg, 28 modified-release tablets
U.S.A. and Puerto Rico: ▲
REQUIP 0.25-5 mg, 100 tablets
REQUIP XL 2 mg, 21, 30 and 90 extended-release tablets
REQUIP XL 4 mg, 30 and 90 extended-release tablets
REQUIP XL 6 mg, 30 extended-release tablets
REQUIP XL 8 mg, 30 and 90 extended-release tablets
REQUIP XL 12 mg, 30 extended-release tablets
ROPINIROLE AMERICAN HEALTH PACK 0.25-2 mg, 100 tablets
ROPINIROLE BRYANT RANCH PREPACK 1 mg, 28, 30 and 90 tablets
ROPINIROLE CADILA HEALTHCARE 0.25-5 mg, 100 tablets
ROPINIROLE COREPHARMA 0.25-5 mg, 100 tablets
ROPINIROLE GLENMARK GENERICS 0.25-5 mg, 100 tablets
ROPINIROLE HERITAGE PHARMA 0.25-5 mg, 100 tablets
ROPINIROLE MAJOR 0.25-5 mg, 100 tablets
ROPINIROLE MYLAN 0.25-5 mg, 100 tablets
ROPINIROLE NCS HEALTHCARE OF KY 0.25-3 mg, 30 tablets
ROPINIROLE PHYSICIANS TOTAL CARE 0.25-5 mg, tablets
ROPINIROLE REBEL 0.25-5 mg, 100 tablets
ROPINIROLE SOLCO 0.25-5 mg, 100 tablets
ROPINIROLE STAT RX USA LLC 1 mg, 28, 30, 60 and 90 tablets
ROPINIROLE STAT RX USA LLC 2 mg, 30, 60 and 90 tablets
ROPINIROLE TEVA 0.25-5 mg, 100 tablets
ROPINIROLE WOCKHARDT 0.25-5 mg, 100 tablets
ROPINIROLE ZHEJIAN HUAHAI 0.25-5 mg, 100 tablets
ROPINIROLE ZYDUS 0.25-5 mg, 100 tablets
Page updated: December 13, 2010.